Name: Su GUAN
Cell phone: 13570396177
Email: guansu@scut.edu.cn
Education & Work Experience
2015.9–present South China University of Technology Associate Professor
2012.9–2015.8 South China University of Technology Lecturer
2010.1 – 2012.8 MSD/ Medical Affairs Medical Advisor
2009.5 – 2009.12 Sun Yat-sen University Cancer Center Research Associate
2007.8 – 2009.4 MD Anderson Cancer Center of University of Texas, USA Postdoctoral Fellow
2002.9–2007.6 Sun Yat-sen University, Pharmacology PhD Student
1997.9–2002.6 Sun Yat-sen University, Clinical Medicine Undergraduate Student
Research Interests and Key Achievements
Study on Pharmacology and Mechanism of New Drugs, identification of biomarkers and new targets in major diseases, drug metabolism and metabolomics. Have published more than 30 papers in SCI and the domestic core journals focus on pharmacology and pharmacodynamics aspects of new compounds, including 10 first author and corresponding author SCI articles. In charge of and participate nearly 10 funds of national, provincial and ministerial level.
Representative research Projects
1.Guangzhou Science and Technology Program, production and research collaborative innovation major projects, Preclinical Study of new Polymorphic Febuxostat (class 2.1), 2017/05-2019/12, in research, project manager.
2.National Natural Science Foundation of China, The Effect and Mechanism of L-BM Induced Hemodynamic Change on Autophagy in Chronic Heart Failure, 2014/01-2016/12, finished, project manager.
3.Central University of basic scientific research, Effects of β2 - agonist R - BM on autophagy in myocardial ischemia - reperfusion injury, 2013/09-2014/12, finished, project manager.
4.Ministry of Education fund of returned overseas students, Study on the mechanism of LMP2A - induced EMT, lateral population cell population and Bmi - 1 expression. 2011/01-2014/12, finished, project manager.
5.National Natural Science Foundation of China, Activation of Platelet and Leukocyte and Regulation of Signal Pathway in Blood Flow Shear Stress. In research, participate.
6.National Natural Science Foundation of China, Protective Mechanism of Drug Pretreatment on Myocardial Ischemia Reperfusion Injury—the effect of STV Na on KATP. 2014/01-2016/12, finished, participate.
7.973 subproject, Development of hepatitis and other major human diseases of the primate model. 2012/01-2013/12, finished, participate.
8.Teaching reform project, The Application of Innovative Bilingual Teaching Mode in the Basic Course of Biopharmaceutical. 2014/09-2016/08, finished, project manager.
Representative paper
1. Guan S, Hu CY, He MY, Yang YY, Tang YX, Chen JD, Huang LJ, Tan W. Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs. Eur J Drug Metab Pharmacokinet. 2015, 40(4):453-60.
2. Guan S, Ren B, Chen J, et al. Effect of Matrine and Oxymatrine on Nevirapine’s Pharmacokinetics in Rats. Lat. Am. J. Pharm. 2015; 34 (6): 1246-51
3. Guan S, Shen R, Lafortune T, et al. Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy. Neuro Oncol. 2011; 13(7):748-58.
4. Shu W, Guan S (contribute equally), Yang X, et al. M. Genetic markers in CYP2C19 and CYP2B6 for prediction of cyclophosphamide's 4-hydroxylation, efficacy and side effects in Chinese patients with systemic lupus erythematosus. Br J Clin Pharmacol. 2016; 81(2): 327-40.
5. Li J, Guan S (contribute equally), Zhang L. Hypolipidemic and antioxidant activities of 4, 5, 6, 7-tetrahydropravastatin sodium as a novel HMG-CoA reductase inhibitor in high-fat diet rats. Lat. Am. J. Pharm. 2016; 35 (6): 1297-303.
6. Sun PP, Yuan F, Xu J, Sai K, Chen J*, Guan S *. Cryptotanshinone Ameliorates Hepatic Normothermic Ischemia and Reperfusion Injury in Rats by anti-mitochondrial Apoptosis. Biol Pharm Bull. 2014; 37(11):1758-65.
7. Guan S, Bi HC, Pan Y, Chen X, Zhou ZW, Xue CCL, Li CG, Huang M, Zhou SF. Determination of cryptotanshinone, a major active component in Salvia miltiorrhiza, in caco-2 monolayers by HPLC with UV detection. Chromatographia. 2007; 66(7-8): 577-82.
8. Guan S, Huang M, Li X, Chen X, Chan E, Zhou SF. Intra- and inter-ethnic differences in the allele frequencies of cytochrome P450 2B6 gene in Chinese. Pharm Res. 2006; 23(9):1983-90.
9. Guan S, Huang M, Chan E, Chen X, Duan W, Zhou SF. Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese. Eur J Pharm Sci. 2006; 29(1):14-21.
10. Zhang J, Huang M, Guan S（contribute equally）, Bi HC, Pan Y, Duan W, Chan SY, Chen X, Hong YH, Bian JS, Yang HY, Zhou S. A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza. J Pharmacol Exp Ther. 2006; 317(3):1285-94.
Others
Patents
1.Ke SAI, Zhongping CHEN, Su GUAN. Skull screw fixation. Utility model patents, Patent No: CN 203943731 U, Authorization date: 2014.11.19.
2.Lei ZHANG，Saifei HE，Shuo ZHANG，Jing LI，Su GUAN. A vortioxetine hemihydrochloric acid and its preparation and pharmaceutical composition. Application date: 2015.08.06.
3.Lei ZHANG, Lei GAO, Ji LI, Su GUAN, Shuo ZHANG. A macrolide antibacterial compound and its preparation method and application. Application date: 2015.10.27.
