Name: PAN LI
Title: Professor, Doctor of engineering, Ph.D. supervisor
Email: btlipan@scut.edu.cn
Education and occupational experience
Education experience
2007 Academic visitor in Sheffield Hallam University, UK
1999 Doctor degree (Fermentation engineering), South China University of Technology (SCUT)
1994 Master degree (Fermentation engineering), SCUT
1988 Bachelor degree (Biochemical engineering), SCUT
Occupational experience
2004 to date School of Bioscience and Bioengineering, SCUT
1994-2004 School of Food and Bioengineering, SCUT
1988-1991 Guizhou Provincial Academy of Sciences
Research fields and main achievements
-Research fields
CRISPR/CAS9 genome editing, protein secretion mechanism and secondary metabolism regulation in filamentous fungi;
Genomics, transcriptomics, proteomics and bioinformatic researches in industrially used microorganisms;
Molecular breeding of high-yielding industrial organisms and synthetic biology.
Industrial application based on the above researches include: (1) Development and large scale production of industrial and medical proteins; (2) Development of novel enzyme preparation used in food, feedstuff, washing, energy, textile and medicine; (3) Characterization and application of microbiological natural active secondary metabolites; (4) Green manufacture of bulk biological products and traditional fermented products.
-Main achievements
I have been in charge of more than twenty research projects supported by National Natural Science Foundation of China (NSFC), Hi-tech Research and Development program of China (863 program), National Key Technology Research and Development Program of the Ministry of Science and Technology of China, Key scientific and technological project in Guangdong Province, Natural science foundation of Guangdong province project for research team, Natural science foundation of Guangdong province project and Enterprise entrusted projects. And more than thirty articles have been published in high-level international academic journals including Nucleic acids research, Journal of Bacteriology and so on. I obtained four national authorized patents and the First prize of scientific and technological progress in Guangdong Province (rank second, 2011).
Representative research projects
[1] National Natural Science Foundation of China (NSFC) project (No. 30970045; Principal Investigator): Endoplasmic reticulum stress response mechanism in filamentous fungal protein secretion pathway (2010.01-2012.12)
[2] National Natural Science Foundation of China (NSFC) project (No. 30770057; Principal Investigator): Unfolded protein response mechanism in filamentous fungal protein secretion pathway (2008.1-2008.12)
[3] Hi-tech Research and Development program of China (863 program No. 2012AA022108; Principal Investigator): Genome-level improvement of microorganisms used in food industry (2012.01-2015.12)
[4] Hi-tech Research and Development program of China (863 program No. 2014AA021304; Principal Investigator): Development and application of recombinant high secretory Bacillus Subtilis expression systems (2014.1-2016.12)
[5] Science and Technology Planning Project of Guangdong Province (No. 2012B010900028; Principal Investigator): Biological preparation of food base grease without trans fatty acids and its application (2013.01-2016.12)
[6] Natural science foundation of Guangdong province project for research team (No. S2012030006235; Principal Investigator): Mechanisms in genetic diversity and hazard formation of Vibrio parahaemolyticus in food (2012.10-2017.10)
[7] Science and Technology Planning Project of Guangdong-Guangdong-HONGKONG joint innovation project (No. 2016A050503016; Principal Investigator): Key technologies for large-scale production of industrial and medical proteins using filamentous fungal expression systems (2015.9-2017.12)
Representative publications
[1] Wang, C., Lv, Y., Wang, B., Yin, C., Lin, Y. and Pan, L.* (2015) Survey of protein-DNA interactions in Aspergillus oryzae on a genomic scale. Nucleic acids research, 43, 4429-4446. (SCI影响因子: 9.1)
[2] Wang B., Guo G., Wang C., Lin Y., Wang X., Zhao M., Guo Y., He M., Zhang Y., and Pan L.*, (2010). Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing. Nucleic acids research, 38(15): 5075‐5087 (SCI影响因子: 7.8)
[3] Zhou, B., Wang, C., Wang, B., Li, X., Xiao, J. and Pan, L.* (2015) Identification of functional cis-elements required for repression of the Taka-amylase A gene under secretion stress in Aspergillus oryzae. Biotechnology letters, 37, 333-341.
[4] Lv, Y., Zhou, F., Wang, B. and Pan, L.* (2015) Morphological transitions under oxidative stress in response to metabolite formation in Aspergillus niger. Biotechnology letters, 37, 601-608.
[5] Yin, C., Wang, B., He, P., Lin, Y. and Pan, L.* (2014) Genomic analysis of the aconidial and high-performance protein producer, industrially relevant Aspergillus niger SH2 strain. Gene, 541, 107-114.
[6] Lv, Y., Xiao, J. and Pan, L.* (2014) Type III polyketide synthase is involved in the biosynthesis of protocatechuic acid in Aspergillus niger. Biotechnology letters, 36, 2303-2310.
[7] Wang, K., Wang, B., Yang, H.L. and Pan, L.* (2013) New strategy for specific activation of recombinant microbial pro-transglutaminase by introducing an enterokinase cleavage site. Biotechnology letters, 35, 383-388.
[8] Yin, Y., Yue, G., Gao, Q., Wang, Z., Peng, F., Fang, C., Yang, X. and Pan, L.* (2012) Genome sequence of Pedobacter arcticus sp. nov., a sea ice bacterium isolated from tundra soil. Journal of bacteriology, 194, 6688.
[9] Yang, H., Liao, Y., Wang, B., Lin, Y. and Pan, L.* (2011) Complete genome sequence of Bacillus amyloliquefaciens XH7, which exhibits production of purine nucleosides. Journal of bacteriology, 193, 5593-5594.
[10] Yang, H., Liao, Y., Wang, B., Lin, Y. and Pan, L.* (2011) Draft genome sequence of Escherichia coli XH001, a producer of L-threonine in industry. Journal of bacteriology, 193, 6406-6407.
Authorized Patents
[1] Li Pan, Bin Zhou, Chao Wang. Feed-back regulators, promotors and plasmids of anti-feedback inhibition, transformants in filamentous fungi under protein secretion stress and their preparation. ZL201310201254.5
[2] Li Pan, Bin Zhou, Pan He, Yangyong Lv. Methodology and reagent kit for extracting filamentous fungal genome DNA and quick screening method for genetic transformants. ZL 201310326924.6
Scientific awards
First prize of scientific and technological progress in Guangdong Province (rank second, 2011)
