Jianhua Wu
time: 2016-08-29

Jianhua Wu




PH.D         1988 Wuhan University of Technology, Wuhan, CHINA

M.S           1984 Wuhan University of Technology, Wuhan, CHINA

B.S            1982 Zhejiang University, Hongzhou, CHINA


Dr. Wu began his research career in hydrodynamics as a lecturer in Wuhan University of Technology in1988. He went to Peking University as a post-doctoral scientist in 1989, and gained his associate professor position in 1991. Later on, he entered into Sun Yat-sen University (SYSU), and became a full professor of fluid mechanics in 1996. Since 2000, Dr Wu was interested in bioengineering, and was a professor of biochemistry in SYSU school of life science. In 2007, he came to South China university of technology and was a professor of biomedical engineering. In Dr. Wu’s Lab, the current researches include experimental, computational and theoretical studies in bioengineering at the cellular and molecular levels. Dr Wu was a research associate in Hong Kong University in 1993-1995, and he spent two years (2001-2003) in Georgia Tech as a visit professor.


The current research projects in the Wu lab focus on the effects of mechanical microenvironment on the receptor-ligand interaction-induced intracellular signaling, cell adhesion and aggregation of cells in the immune system and the vascular system. The goal of Dr. Wu’ research is to gain a fundamental understanding of biological processes relative to human health and diseases (such as cardiovascular disease and cancer) at gene, protein, cell and tissue levels. The experiments utilize state-of-the-art technologies, including flow chamber, atomic force microscopy, real-time laser scanning confocal microscopy and etc. The force-induced change of both structure and function of protein is measured experimentally using ultrasensitive techniques at pN and nm levels and analyzed theoretically by molecular dynamics simulations. Dr. Wu's research are primarily funded by the National Natural Science Foundation of China (NSFC)


NSFC Grant No:11432006 (PI: Jianhua Wu), RMB$ 3600,000.  

01/1/15-31/12/19     Regulation of Wall Shear Stresses on Blood Plate/Leukocyte Activations and Their Signal Pathways

SCUT FRFCU Grant (PI: Jianhua Wu), RMB$500,000

01/9/15-31/9/17        Mechanical Regulation Mechanism of Plate and Leukocyte Activation

NSFC Grant No:31170887 (PI: Jianhua Wu), RMB$ 650,000. 

01/1/12-31/12/15     Regulation of Force on Selectin-mediated Integrin LFA-1 Activation

NSFC Grant No:11072080 (PI: Jianhua Wu), RMB$ 460,000

01/1/11-31/12/13      Force-dependent Hydrolyzing of von Willebrand Factor by Metalloprotease ADMATS-13

NSFC Grant No:10772069 (PI: Jianhua Wu), RMB$ 460,000

01/01/08-31/12/10   The Relation between Activity and Flexibility of the Linear Cationic α-Helical Antimicrobial Peptide

NSFC Grant No:10772069 (PI: Jianhua Wu), RMB$ 300,000

01/01/06-31/12/08   Study on Flow-Enhanced Adhesion of Cell

NIH 1R03TW007529-01 (FC: Jianhua Wu), USD$ 96,000

15/04/06-28/02/09   Biophysical Analysis of Leukocyte Adhesion Under Flow.


Huang, B., Y. Ling, J. Lin, Y. Fang and J. Wu. Force-dependent calcium signaling and its pathway of human neutrophils on P-selectin in flow. Protein & Cell. 2017, 8(2):103-113.

Li, Q., A. Wayman, J Lin, Y. Fang, C. Zhu, and J. Wu. Flow-enhanced stability of rolling adhesion through E-selectin. Biophysical Journal, 2016, 114(4): 686-99

Liu, G., Y. Fang and J. Wu. A mechanism for localized dynamics-driven affinity regulation of the binding of von Willebrand Factor to platelet glycoprotein Ibα, Journal of Biological Chemistry, 2013, 288(37): 26658-26667

Liu, L., Y. Fang and J. Wu. Flexibility is a mechanical determinant of antimicrobial activity for amphipathic cationic a-helical antimicrobial peptides. Biochimica et Biophysica Acta –Biomembranes, 2013, 1828(11):2479-2486

Fang, X, Y. Fang, L. Liu, G. Liu and J. Wu. 2012. Mapping paratope on antithrombotic antibody 6B4 to epitope on platelet glycoprotein Ibα via molecular dynamic simulations. PLoS ONE 7(7): e42263

Sun, T., H. Wang and J. Wu. 2012. Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases. Scientific Reports 2: 261

Liu, L., Y. Fang, Q. Huang and J. Wu. A rigidity-enhanced antimicrobial activity: a case for linear cationic α-helical peptide HP(2–20) and its four analogues. PLoS ONE, 2011, 6(1): e16441.

Wu, J, Y. Fang, V.I. Zarnitsyna, T.P. Tolentino, M.L. Dustin and C. Zhu. A coupled diffusion-kinetics model for analysis of contact area FRAP experiment. Biophysical Journal. 2008, 95(2): 910- 919

Wu, J, Y. Fang, D. Yang and C. Zhu. Thermo-mechanical Responses of a Surface-coupled AFM Cantilever. Journal. Biomechanical Engineering, ASME. 2005, 127(7):1208-1215

Yago, T, J. Wu, C.D. Wey, A.G. Klopocki, C. Zhu and R.P. McEver. 2004. Catch bonds govern adhesion through L-selectin at threshold shear. J. of Cell Biology, 2004, 166(6): 913-923

Wu, J. and A.T. Chwang. Wave diffraction by a vertical cylinder with a porous ring plate. J. of Engineering Mechanics, 2002, 128(2): 164-171

Wu, J., Z. Wan and Y. Fang. Wave reflection by a vertical wall with a horizontal submerged porous plate. Ocean Engineering. 1998, 25(9): 767-779