Shan Li
time: 2015-07-03

Tel13249649282,Email:lishan@scut.edu.cn

Research interests: biochemistry and molecular biology, protein engineering,Monoclonal antibodies, screening of antibodies and immunotherapy

Education:

1991/09-1995/07,  B.S degree in biochemistry, Lanzhou university, China

1997/09-2001/12,  PhD degree in biology,  Lanzhou university, China

Research experience:

2002/10-2005/05  Postdoctoral fellow, School of life Sciences and Biotechnology, Shanghai JiaoTong university, China

2005/05-2007/12  Teacher , School of life Sciences shanghai university, China

2010/05-2013/8  Postdoctoral fellow  University of Maryland, USA

2008/01-now    Associate Professor, School of biology and Biological engineering, South China University of Technology, China

Research project

1. The natural science foundation of Guangdong Province 201508020110 “Molecular mechanism of CPD domain and cytotoxicity of Clostridium difficile2016/01-2018/12

2. Collaborative innovation and platform construction in Guangdong - International Cooperation in science and technology  2015A050502016“Study on the key technique of recombinant Lactobacillus as treatment of Clostridium difficile infection 2015/01-2017/12 

3.Guangzhou industry university research cooperative innovation major project:201508020110 “Detection of major viral infectious pathogens by isothermal amplification of nucleic acid”。 2014/01-2017/12 

4.Provincial Foreign Exchange Project  2011B050400016 “Research and development of recombinant Clostridium difficile immunotoxin for the treatment of AML”。2011/01-2013/12   

Representative papers:

1Li J, Li LY, He SF, Li S*, Dong CZ, Zhang L. Crystal Structures, X-Ray Photoelectron Spectroscopy, Thermodynamic Stabilities, and Improved Solubilities of 2-Hydrochloride Salts of Vortioxetine.  J Pharm Sci. 2017

2Xian-Rui Zhang , Sai-Fei He , Shuo Zhang , Jing Li , Shan Li a **, Jin-Song Liu ,

Lei Zhang* , Polymorphs and solvatomorphs of azilsartan medoxomil: Elucidation of solvent-induced construction and conformational diversity Journal of Molecular Structure 1130 (2017) 103-113

3) Lin Xia, Weihong Gu, Mingyi Zhang, Ya-Nan Chang, Kui Chen, Xue Bai, Lai Yu, Juan Li, Shan Li* and Gengmei Xing, Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation. Paticle and Fibre Toxicology 2016 Nov 29;13(1):63

4Ma Y, Zhang B, Wang M, Ou Y, Wang J, Li S*.Enhancement of Polymerase Activity of the Large Fragment in DNA Polymerase I from Geobacillus stearothermophilus by Site-Directed Mutagenesis at the Active Site. Biomed Res Int. 2016; 2016:2906484. Epub 2016 Nov 17.

5Fan-zhi Kong, Ying Yang, b, Yu-chen He, Qiang Zhang,Guo-qing Li,Liu-yin Fan, Hua Xiao ,Shan Li,* and Cheng-xi Cao, Design of suitable carrier buffer for free-flow zone electrophoresis by charge-to-mass ratio and band broadening analysis. Electrophoresis 2016 Sep;37(17-18):2393-400

6Ji Liu, Yi Ma, Chun-Li Sun, Shan Li* and Ju-Fang Wang, High mobility group box1 protein is involved in endoplasmic reticulum stress induced by Clostridium difficile toxin A. Biomed Res Int. 2016;2016:4130834. doi: 10.1155/2016/4130834. Epub 2016 Aug 7

7Y. Yang, F. Z.Kong, J. Liu, J. M. Li, X. P. Liu, G. Q. Li, J. F. Wang, H. Xiao, L. Y. Fan, C. X. Cao, S. Li*  Enhancing resolution of free flow zone electrophoresis via a simple sheath-flow sample injection. Electrophoresis 2016 Jul;37(14):1992-7

8Sai-Fei He, Xian-Rui Zhang, Shuo Zhang, Su Guan, Jing Li, Shan Li* , Lei Zhang, An Investigation Into Vortioxetine Salts: Crystal Structure, Thermal Stability, and Solubilization. J Pharm Sci. 2016 Jul;105(7):2123-8

9Liu Ji, Zhang Bei-Lei, Sun Chun-Li, Wang Jun, Li Shan*,Wang Ju-Fang, High mobility group box1 protein is involved in acute inflammation induced by Clostridium difficile toxin A. Acta Biochim Biophys Sin (Shanghai). 2016 Jun; 48(6):554-62.

10Shan Li, Lianfa Shi, Zhiyong Yang, Yongrong Zhang, Gregorio Perez-Cordon, Tuxiong Huang, Jeremy Ramsey, NumanOezguen, Tor C. Savidge, Hanping Feng. Critical Roles of Clostridiumdifficile Toxin B Enzymatic Activities in Pathogenesis. IAI  2015 2 (83):502-513