
Tel:13249649282,Email:lishan@scut.edu.cn
Research interests: biochemistry and molecular biology, protein engineering,Monoclonal antibodies, screening of antibodies and immunotherapy
Education:
1991/09-1995/07, B.S degree in biochemistry, Lanzhou university, China
1997/09-2001/12, PhD degree in biology, Lanzhou university, China
Research experience:
2002/10-2005/05 Postdoctoral fellow, School of life Sciences and Biotechnology, Shanghai JiaoTong university, China
2005/05-2007/12 Teacher , School of life Sciences shanghai university, China
2010/05-2013/8 Postdoctoral fellow University of Maryland, USA
2008/01-now Associate Professor, School of biology and Biological engineering, South China University of Technology, China
Research project:
1. The natural science foundation of Guangdong Province 201508020110 “Molecular mechanism of CPD domain and cytotoxicity of Clostridium difficile” 2016/01-2018/12
2. Collaborative innovation and platform construction in Guangdong - International Cooperation in science and technology 2015A050502016“Study on the key technique of recombinant Lactobacillus as treatment of Clostridium difficile infection 2015/01-2017/12
3.Guangzhou industry university research cooperative innovation major project:201508020110 “Detection of major viral infectious pathogens by isothermal amplification of nucleic acid”。 2014/01-2017/12
4.Provincial Foreign Exchange Project 2011B050400016 “Research and development of recombinant Clostridium difficile immunotoxin for the treatment of AML”。2011/01-2013/12
Representative papers:
1)Li J, Li LY, He SF, Li S*, Dong CZ, Zhang L. Crystal Structures, X-Ray Photoelectron Spectroscopy, Thermodynamic Stabilities, and Improved Solubilities of 2-Hydrochloride Salts of Vortioxetine. J Pharm Sci. 2017
2)Xian-Rui Zhang , Sai-Fei He , Shuo Zhang , Jing Li , Shan Li a **, Jin-Song Liu ,
Lei Zhang* , Polymorphs and solvatomorphs of azilsartan medoxomil: Elucidation of solvent-induced construction and conformational diversity Journal of Molecular Structure 1130 (2017) 103-113
3) Lin Xia, Weihong Gu, Mingyi Zhang, Ya-Nan Chang, Kui Chen, Xue Bai, Lai Yu, Juan Li, Shan Li* and Gengmei Xing, Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation. Paticle and Fibre Toxicology 2016 Nov 29;13(1):63
4)Ma Y, Zhang B, Wang M, Ou Y, Wang J, Li S*.Enhancement of Polymerase Activity of the Large Fragment in DNA Polymerase I from Geobacillus stearothermophilus by Site-Directed Mutagenesis at the Active Site. Biomed Res Int. 2016; 2016:2906484. Epub 2016 Nov 17.
5)Fan-zhi Kong, Ying Yang, b, Yu-chen He, Qiang Zhang,Guo-qing Li,Liu-yin Fan, Hua Xiao ,Shan Li,* and Cheng-xi Cao, Design of suitable carrier buffer for free-flow zone electrophoresis by charge-to-mass ratio and band broadening analysis. Electrophoresis 2016 Sep;37(17-18):2393-400
6)Ji Liu, Yi Ma, Chun-Li Sun, Shan Li* and Ju-Fang Wang, High mobility group box1 protein is involved in endoplasmic reticulum stress induced by Clostridium difficile toxin A. Biomed Res Int. 2016;2016:4130834. doi: 10.1155/2016/4130834. Epub 2016 Aug 7
7)Y. Yang, F. Z.Kong, J. Liu, J. M. Li, X. P. Liu, G. Q. Li, J. F. Wang, H. Xiao, L. Y. Fan, C. X. Cao, S. Li* Enhancing resolution of free flow zone electrophoresis via a simple sheath-flow sample injection. Electrophoresis 2016 Jul;37(14):1992-7
8)Sai-Fei He, Xian-Rui Zhang, Shuo Zhang, Su Guan, Jing Li, Shan Li* , Lei Zhang, An Investigation Into Vortioxetine Salts: Crystal Structure, Thermal Stability, and Solubilization. J Pharm Sci. 2016 Jul;105(7):2123-8
9)Liu Ji, Zhang Bei-Lei, Sun Chun-Li, Wang Jun, Li Shan*,Wang Ju-Fang, High mobility group box1 protein is involved in acute inflammation induced by Clostridium difficile toxin A. Acta Biochim Biophys Sin (Shanghai). 2016 Jun; 48(6):554-62.
10)Shan Li, Lianfa Shi, Zhiyong Yang, Yongrong Zhang, Gregorio Perez-Cordon, Tuxiong Huang, Jeremy Ramsey, NumanOezguen, Tor C. Savidge, Hanping Feng. Critical Roles of Clostridiumdifficile Toxin B Enzymatic Activities in Pathogenesis. IAI 2015 2 (83):502-513