哥本哈根大学Dennis S. Nielsen教授:The role of bacteriophages in the gut - and their potential use for gut microbiome manipulation
报告题目:The role of bacteriophages in the gut - and their potential use for gut microbiome manipulation
报 告 人:Dennis S. Nielsen (哥本哈根大学教授,丹麦技术科学院院士)
报告时间:2026年10月29日(星期四)上午10:30—11:30
报告地点:大学城校区B6楼207报告厅
主办单位:生物科学与工程学院
报告摘要:
Gut microbiome (GM) dysbiosis have been found to precede metabolic diseases like obesity, immune diseases like asthma and other gut-related diseases, making intervention through GM manipulation attractive. Bacteriophages (phages) are viruses attacking bacteria in a host specific manner. There is growing understanding that phages (and possibly other components of the gut virome) play key roles in shaping GM composition and consequently influence the trajectory towards health or disease. During recent years the ability of more or less complex consortia of phages and even undefined fecal viromes (sterile-filtered faeces) have shown great promise in alleviating GM dysbiosis related diseases such as Clostridioides difficile infection, metabolic syndrome and necrotizing enterocolitis. In this talk, the role of phages in gut health will and lined out and examples of the use of phages and fecal viromes for treating GM dysbiosis related diseases will be given.
报告人简介:
Dennis Sandris Nielsen,丹麦技术科学院院士、哥本哈根大学食品科学学院教授,现任食品微生物学、肠道健康与发酵系主任。长期致力于食品微生物学、肠道微生物组及其与宿主健康相互作用的研究。其研究涵盖不同膳食成分、益生元、益生菌、后生元及噬菌体等对肠道微生态的调控机制,并结合体外模型、动物实验和人体干预等研究,系统探索微生物组与宿主健康之间的关联及作用机制。Nielsen教授现任期刊FEMS Microbiology Reviews主编与 Gut Microbiology副主编,担任丹麦独立研究基金会(Independent Research Fund Denmark)-技术与生产科学领域委员会委员,并多次受邀担任英国、美国、新西兰、比利时、荷兰、瑞典、葡萄牙及卡塔尔等国家和地区科研基金的评审专家。作为项目负责人,其研究获得Independent Research Fund Denmark、丹麦创新基金会(Innovation Fund Denmark)、灵北制药(Lundbeck)、维拉姆基金会(Villum Foundation)、诺和诺德基金会(Novo Nordisk Foundation)、欧盟及多家企业的资助,累计科研经费约1.69亿丹麦克朗(2260万欧元)。此外,他积极参与科学传播与公众科普,通过高校宣传、科学文化活动及食品主题交流平台等渠道,多次面向社会公众开展演讲,不断推动食品微生物学与肠道健康相关科学知识的传播。截至目前,Nielsen教授已在Nature Medicine、Gut、Nature Microbiology、Nature Communications、The ISME Journal、Microbiome、Gut Microbes等国际知名学术期刊发表论文320余篇,谷歌学术总引用22,000余次,H指数75,在食品微生物学与肠道微生物组领域具有广泛的国际学术影响力。