| 姓名：熊伟 职称：教授，博士生导师，海外高层次引进人才 研究方向：合成生物学、生物碳中和与一碳代谢、人工智能+生物学、能源生物技术 办公地点：广州番禺大学城华南理工大学南校区B6 办公电话：020-39380669 |
博士生：生物学
硕士生：微生物学
1998—2002 华中农业大学 微生物学 学士
2002—2005 华中农业大学 微生物学 硕士
2005—2010 清华大学 生物学 博士
2010—2013 美国亚利桑那州立大学 博士后研究员
2013—2016 美国可再生能源国家实验室 主任研究学者
2016—2018 美国可再生能源国家实验室科学家
2018—2024.04 美国可再生能源国家实验室资深科学家（终身研究职位）
2024.05—至今 华南理工大学 教授
本科生教学：主讲生物工程专业相关本科课程
本科生导师制：作为本科生导师，指导学生创新创业活动。为学生提供职业发展指导。
研究生教学：主讲《生命科学前沿》及《生物工程前沿》课程，年均招收硕士生3-4名，博士生2-4名。
合成生物学、生物碳中和与一碳代谢、人工智能+生物学、能源生物技术
1.美国能源部生物能源技术项目——DOE Bioenergy Technologies Office (BETO), CO-Optima project (2021-2022, 主持) (项目名称: Rational Optimization of Microbial Processing for High Yield CO2 -to-Isopropanol Conversion)
2.美国能源部生物与环境研究项目——DOE Biological and Environmental Research (BER), Scientific Focus Area (SFA) project (2021-2023, 共同主持) (项目名称: IMAGINE BioSecurity: Integrative Modeling and Genome-scale Engineering for Biosystems Security)
3.壳牌石油合作研发项目——Shell BlueSky Project (Shell) (2020, 主持) (项目名称: Hybrid CO2 Valorization to High Titer Isopropanol)
4.国家实验室预研项目——Seed NREL Laboratory Directed Research and Development
Program (LDRD) (2019, 主持) (项目名称: Photoexcited Electrons to Molecules)
5.国家实验室预研项目——Seed NREL Laboratory Directed Research and Development
Program (LDRD) (2019, 主持) (项目名称: Machine Learning-Based Fluxomics Framework)
6.美国能源部生物能源技术项目——DOE Bioenergy Technologies Office Program (BETO)
(2018–2021, 主持) (项目名称: Synthetic C1 Condensation Cycle for Formate-Mediated
ElectroSynthesis)
7.国家实验室研发项目——NREL Laboratory Directed Research and Development Program
(LDRD) (2017-2019, 主 持 ) ( 项目名称 : Reductive Acetyl CoA Bi-cycle for Syngas
Bioconversion)
8.国家实验室研发项目——NREL Laboratory Directed Research and Development Program
(LDRD) (2017-2019, 共 同 主 持) (项目名称: Redox Activity of Single-Walled Carbon
Nanotube-Clostridium Hybrid for Microbial Electrosynthesis)
9.国家实验室主任研究基金 The NREL Director’s Fellowship (2015-2016, 主持) (项目名称: An evolutionary approach to increase the tolerance to biomass hydrolysates in Clostridium thermocellum)
10.国家实验室主任研究基金 The NREL Director’s Fellowship (2013-2015, 主持) (项目名称: Synthetic TCA cycle for photo-biological production of ethylene from cyanobacteria)
重要研究进展以通讯或第一作者发表在《美国科学院院刊》、《自然植物学》、《能源与环境科学》、《代谢工程》、《ACS 合成生物学》、《分子微生物学》等国际一流期刊上；引用逾 2000 次， 详见 Google 学术，链接如下) (*通讯作者, †共同一作)
https://scholar.google.com/citations?user=scYzTwkAAAAJ&hl=zh-CN
1. Zhaodong Li, Chao Wu†, Xiang Gao†, Bennett Addison, Xihan Chen, Jianping Yu,
Drazenka Svedruzic, Jeffrey Blackburn*, Wei Xiong*. Exogenous Electricity Flowing
through Cyanobacterial Photosystem I Drives CO2 Valorization with High Energy
Efficiency. Energy and Environmental Science 2021, DOI: 10.1039/D1EE01526E (IF=38.5，5Y-IF =36)
新闻报道：
英国皇家学会 Chemistry World 刊发名为 Cyanobacteria engineered to accept external electricity
turn carbon dioxide into fuel 的专题采访
https://www.chemistryworld.com/news/cyanobacteria-engineered-to-accept-external-electricity
turn-carbon-dioxide-into-fuel/4014457.article
搜狐/网易-美国科学家新工程：改造蓝藻，使其利用电力将二氧化碳转化为燃料
麻省理工科技评论：设计全新光电合成途径，有望改变生物燃料游戏规则
2. Wei Xiong, John Morgan, Justin Ungerer, Bo Wang, PinChing Maness, Jianping Yu. The plasticity of cyanobacterial metabolism supports direct CO2 conversion to ethylene. Nature Plants. 2015. doi:10.1038/nplants.2015.53.
《自然植物学》刊发名为 Metabolic engineering: Kick-starting TCA cycling 的专题评述报道. Nature Plants. 2015 https://www.nature.com/articles/nplants201558
3. Wei Xiong, Tai-Chi Lee, Sarah Rommelfanger, Erica Gjersing, PinChing Maness, Maria Ghirardi, Jianping Yu. Phosphoketolase pathway contributes to the carbon metabolism in cyanobacteria. Nature Plants. 2015, 2: 15187
4. Wei Xiong, Paul P. Lin, Lauren Magnusson, Lisa Warner, Jam es C. Liao, Pin-Ching Maness, Katherine J. Chou. CO2 -fixing one-carbon metabolism in a cellulose-degrading bacterium Clostridium thermocellum. Proceedings of the National Academy of Sciences. 2016, 113 (46), 13180-13185
该论文荣获可再生能源国家实验室（NREL）当年度最佳研究论文
5. Chao Wu, Jianping Yu, Michael Guarneri, Wei Xiong*. A Computational Framework for Machine Learning-Enabled 13C-Fluxomics. ACS Synthetic Biology. 2021
10.1021/acssynbio.1c00189 (封面)
6. Chao Wu, Huaiguang Jiang, Isha Kalra, Xin Wang, Melissa Cano, PinChing Maness,
Jianping Yu, Wei Xiong*. A generalized computational framework to streamline
thermodynamics and kinetics analysis of metabolic pathways. Metabolic Engineering.
2020,57,140-150
7. Chao Wu, Melissa Cano, Xiang Gao, PinChing Maness, Wei Xiong*, A quantitative lens on anaerobic life: leveraging the state-of-the-art fluxomics approach to explore clostridial metabolism. Current Opinion in Biotechnology. 2020, 64, 47-54
8. Wei Xiong*, Melissa Cano, Bo Wang, Damien Douchi, and Jianping Yu*. The plasticity of cyanobacterial carbon metabolism. Current Opinion in Chemical Biology. 2017,41:12-19
9. Wei Xiong*, Luis H. Reyes, William E. Michener, PinChing Maness*, Katherine J. Chou*. Engineering cellulolytic bacterium Clostridium thermocellum to ferment cellulose- and hemicellulose-derived sugars simultaneously. Biotechnology and Bioengineering. 2018,115:1755–1763.
10. Wei Xiong, Daniel Brune and Wim Vermaas. The γ-Aminobutyric acid shunt contributes to closing the tricarboxylic acid cycle in Synechocystis sp. PCC 6803. Molecular Microbiology. 2014, 93 (4): 786-796
11. Wei Xiong, Lixia Liu, Chao Wu, Chen Yang, Qingyu Wu. 13C tracer and GC-MS analyses
reveal metabolic flux distribution in oleaginous microalga Chlorella protothecoides. Plant Physiology. 2010, 154: 1001-1011
12. Wei Xiong, Chunfang Gao, Dong Yan, Chao Wu, Qingyu Wu. Double CO2 fixation in
photosynthesis–fermentation model enhances algal lipid synthesis for biodiesel production. Bioresource Technology. 2010, 101(7): 2287-2293
13. Wei Xiong*, Jonathan Lo, Katherine Chou, Chao Wu, Lauren Magnusson, Tao Dong,
PinChing Maness*. Isotope-assisted metabolite analysis sheds light on central carbon metabolism of a model cellulolytic bacterium Clostridium thermocellum. Frontiers in Microbiology. 2018, 10: 3389.
14. Wei Xiong*, Huaiguang Jiang, PinChing Maness. Dynamic flux analysis: an experimental approach of fluxomics. Methods in Molecular Biology. Metabolic Pathway Engineering. pp 179-196
15. Chao Wu, Chia-hsin Chen, Jonathan Lo, Williem Michener, Pinching Maness, Wei Xiong*. EMUlator: an elementary metabolite unit (EMU) based isotope simulator enabled by adjacency matrix. Frontiers in Microbiology. 2019,10: 3389.
16. Xiang Gao, Chao Wu, Michael Cantrell, Melissa Cano, Jianping Yu, Wei Xiong*. What we can learn from measuring metabolic fluxes in cyanobacteria. Book chapter for Cyanobacteria Biotechnology. Wiley, 2021
17. Chao Wu, Ryan Herold, Bo Wang, Wei Xiong*. Lieve Lauren*. Fluxomic analysis reveals central carbon metabolism adaptation for diazotroph Azotobacter vinelandii ammonium excretion. Scientific Reports. 2019, 9, 13209
18. Bo Wang†, Wei Xiong†, Jianping Yu, PinChing Maness, Deirdre Meldrum. Unlocking the photobiological conversion of CO2 to (R)-3-hydroxybutyrate in cyanobacteria. Green Chemistry. 2018, 20 (16), 3772-3782
19. Tai-Chi Lee†, Wei Xiong†, Troy Paddock, Damian Carrieri, Ing-Feng Chang, Hui-Fen Chiu, Maria Ghirardi, Justin Ungerer, Suh-Hang Hank Juo, Pin-Ching Maness, Jianping Yu. Engineered xylose utilization enhances bio-products productivity in the cyanobacterium Synechocystis PCC 6803. Metabolic Engineering. 2015, 30: 179–189
20. Chao Wu†, Wei Xiong†, Junbiao Dai, Qingyu Wu. Genome-based metabolic mapping and 13C flux analysis reveal systematic properties of an oleaginous microalga Chlorella protothecoides. Plant Physiology. 2015, 167(2): 586-599.
21. Wei Xiong, Xiufeng Li, Jinyi Xiang, Qingyu Wu. High-density fermentation of microalga Chlorella protothecoides in bioreactor for microbio-diesel production. Applied Microbiology and Biotechnology 2008, 78 (1): 29-36.
22. Wei Xiong, Mingjia He, Xiufeng Li, Yang Gao, Qingyu Wu. Identification and biochemical properties of Dps (starvation-induced DNA binding protein) from cyanobacterium Anabaena sp. PCC 7120. IUBMB Life. 2007,59 (10):675-681
23. Wei Xiong, Yunxiang Liang, Yinghua Zheng. Enhancement and selective production of oligomycin through inactivation of avermectin’s starter unit in Streptomyces avermitilis. Biotechnology Letters. 2006, 28(12):911-916
