姓名:周婷 职称:副教授,硕士生导师,2018年广州市珠江科技新星 研究方向:医药生物学、药学 电子邮箱:tingzhou@scut.edu.cn 办公地点:广州市大学城华南理工大学B6栋502室 |
学术型硕士:医药生物学
专业学位硕士:药学、生物与医药(生物工程)
2002-2006 中国药科大学国家生命科学与技术人才培养基地班 学士
2006-2008 中国药科大学硕士
2008-2011 中山大学博士
2012.03-2014.10华南理工大学生物科学与工程学院讲师
2014.11-至今 华南理工大学生物科学与工程学院副教授
本科生教学:讲授本科生课程《药物分析》、《药理学》、《现代生物分析仪器原理与实验》,指导本科生SRP项目。
担任本科生导师,指导本科生创新基金项目。
研究生教学:教授研究生课程《药物分析新方法》、《生命科学高等仪器原理及应用》、《药物色谱质谱分析原理》等。
科研兴趣
1. 生物样品前处理-色谱质谱在线联用分离分析;
2. 代谢组学、脂质组学研究;
3. 手性药物立体选择性代谢及代谢产物研究。
担任Journalof Chromatography A, Analytical and Bioanalytical Chemistry, Journal ofSeparation Science, RSC Advances, Phytochemical Analysis等多个期刊的审稿人。
科研项目
1、国家自然科学基金面上项目:变相聚焦-超临界衍生萃取-色谱质谱联用技术在不饱和脂质分析中的应用,2024.01-2027.12(主持)
2、国家自然科学基金面上项目:柱前稀释固相萃取-超临界流体色谱质谱在线联用技术及其在手性药物分析中的应用,2018.01-2021.12(主持)
3、国家自然科学基金青年基金项目:微波辅助衍生-UPLC-MS/MS联用技术及在手性药物分析中的应用,2015.01-2017.12(主持)
4、广东省自然科学基金面上项目:超临界脱水萃取-变压聚焦色质联用及在脂质组学分析中的应用,2021.01-2023.12(主持)
5、广东省自然科学基金博士启动项目:在线手性衍生-液质联用及在β2-激动剂分析中的应用,2013.10-2015.10(主持)
6、广州市珠江科技新星专项:基于固相萃取-超临界流体色谱-质谱联用技术的脑卒中脂质组学研究,2018.04-2021.03(主持)
7、广州市应用基础研究计划项目:极性分流二维液相色谱质谱联用技术及在抑郁症代谢组学中的应用,2022.04-2024-03(主持)
8、中央高校基本科研业务费面上项目:基于SFE-SFC-MS联用技术的脑卒中脂质组学研究,2018.09-2020.08(主持)
9、中央高校基本科研业务费面上项目:β2-激动剂的手性分析及手性转化研究,2015.01-2016.12(主持)
10、中央高校基本科研业务费博士启动项目:β2-受体激动剂代谢的立体选择性研究,2013.01-2014.12(主持)
1.Zhou M, Li T, Shen L, Zhong Q, Huang T, Zhou T*.Enhanced authentication of organic milk using MALDI-TOF MS with combinedlipid-peptide fingerprinting and machine learning integration. FoodChemistry, 2025, 475: 143346.
2.黄龙会, 石幸玉, 谢海洲, 周婷*. 基于化学衍生化的质谱技术在脂质分析中的研究进展. 分析测试学报, 2025,44(01): 73-81.
3.Shi X, Zheng W, He B, Huang L, Zhong Q, Yang Y, ZhouT*, Huang Y*. UPLC-Q-TOF/MS-based urine metabolomics for the diagnosis andstaging of bladder cancer. Clinica Chimica Acta, 2025, 565: 120022.
4. Huang,L., Huang M., Zhou T.*, Efficient Strategy for Characterization andQuantification of Polyunsaturated Lipids by Microwave-Assisted MMPPEpoxidation. Analytical Chemistry,2024. 96(28): 11189-11197.
5.Zhang L, Cai Y, Zhong Q, Zhang S, Shen L, Huang T, ZhouT*. Comprehensive characterization of active components in Salviamiltiorrhiza using polarity-partitioned two-dimensional liquid chromatographycoupled with mass spectrometry. Journal of Chromatography A, 2024, 1736:465424.
6. HeB, Zhou T*, Liu J. Lipidomics Study of Type 1 Diabetic Rats Using OnlinePhase Transition Trapping-Supercritical Fluid Extraction-Chromatography Coupledwith Quadrupole Time-of-Flight Tandem Mass Spectrometry. Journal of ProteomeResearch, 2024, 23(7): 2619-2628.
7.He B, Ye F, Feng J, Zhou T*. Enhancedlipidomics analysis of breast cancer cells using three-phase liquid extractionand ultra high-performance liquid chromatography coupled with quadrupoletime-of-flight tandem mass spectrometry. Journal of Separation Science,2024, 47(21): e70014.
8.He B, Feng J, Liu J,Zhong Q, Zhou T*. Inlinephase transition trapping-selective supercritical fluidextraction-supercritical fluid chromatography: A green and efficient integratedmethod for determining prohibited substances in cosmetics. Analytica ChimicaActa, 2023, 1279: 341831.
9.Zhang, L., Shen, L.,Zhong, Q., Zhou, T.*. Dilutingmodulation-based two dimensional-liquid chromatography coupled with massspectrometry for simultaneously determining multiclass prohibited substances incosmetics. Journal of Chromatography A, 2023, 1695, 463954.
10.Feng J, Zhong Q, Zhou, T.*. Online Pressure ChangeFocusing-Supercritical Fluid Selective Extraction Chromatography for AnalyzingChiral Drugs in Microliter-Scale Plasma Samples. Analytical Chemistry,2022,94(46): 16222-16230.
11.Huang M, Zhou, T.*. Comprehensive pseudotargetedmetabolomics analysis based on two-phase liquid extraction-UHPLC-MS/MS for theinvestigation of depressive rats. Journal of Separation Science, 2022,45(15), 2977-2986.
12.Feng J, Zhong Q,Kuang J, Liu J, Huang T, Zhou, T.*.Simultaneous Analysis of the Metabolome and Lipidome Using Polarity PartitionTwo-Dimensional Liquid Chromatography–Mass Spectrometry. AnalyticalChemistry, 2021, 93: 15192-15199.
13.Liu D, Yang J, JinW, Zhong Q, Zhou, T.*. A highcoverage pseudotargeted lipidomics method based on three-phase liquidextraction and segment data-dependent acquisition using UHPLC-MS/MS withapplication to a study of depression rats. Analytical andBioanalytical Chemistry, 2021, 413:3975-3986.
14.Jin W, Yang J, LiuD, Zhong Q, Zhou, T.*. Determinationof inflammation-related lipids in depressive rats by on-line supercriticalfluid extraction-supercritical fluid chromatography-tandem mass spectrometry. Journalof Pharmaceutical and Biomedical Analysis, 2021, 203: 114210.
15.Yang J, Liu D, JinW, Zhong Q, Zhou, T.*. A green andefficient pseudotargeted lipidomics method for the study of depression based onultra-high performance supercritical fluid chromatography-tandem massspectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2021,192: 113646.
16.Liang, Y., Liu, J.,Zhong, Q., Huang, T., Zhou, T.*, Anautomatic online solid-phase dehydrate extraction-ultra-high performancesupercritical fluid chromatography-tandem mass spectrometry system using adilution strategy for the screening of doping agents in human urine. Analytica ChimicaActa, 2020, 1101,184-192.
17.杨吉娜, 刘丹阳, 周婷*. 基于色谱-质谱联用的脂质分析样品前处理技术研究进展(英文). 色谱, 2020, 38: 74-85.
18.Yang, J., Jin, W.,Liu, D., Zhong, Q., Zhou, T.*, Enhancedpseudotargeted analysis using a segment data dependent acquisition strategy byLC-MS/MS for a metabolomics study of liquiritin in the treatment of depression.Journal of Separation Science, 2020, 43(11): 2088-2096.
19.Jin, W., Zhou, T.*, Li, G*, Recent advances of modern sample preparation techniques fortraditional Chinese medicines. Journal of Chromatography A, 2019, 1606: 460377. 发表日期:2019.11.22 (Q1,4.049)
20.Yang, Y., Liang, Y.,Yang, J., Ye, F., Zhou, T.*, Gongke,L. Advances of supercritical fluid chromatography in lipid profiling, Journal ofPharmaceutical Analysis, 2019, 9: 1-8.
21.Liang, Y.; Liu, J.;Zhong, Q.; Yu, D.; Yao, J.; Huang, T.; Zhu, M.; Zhou, T.*, A fully automatic cross used solid-phase extractiononline coupled with ultra-high performance liquid chromatography–tandem massspectrometry system for the trace analysis of multi-class pharmaceuticals inwater samples. Journal of Pharmaceutical and Biomedical Analysis 2019, 174, 330-339. 发表日期:2019.09.10 (Q2,3.209)
22.Ye, F., Zhong, Q.,Liang, Y., Zhou T.*. Determinationof lipid mediators in breast cancer cells using lyophilization-supercriticalfluid extraction online coupled with supercritical fluidchromatography-quadrupole tandem mass spectrometry. Journal ofSeparation Science, 2020, 43: 1800-1807.发表日期:2020.05
23.Ye F, Liu S, Yang Y,Zhao T, Li S, Zhou T.*, Tan W*. Identification of the majormetabolites of (R)-salbutamol in human urine, plasma and feces using ultra highperformance liquid chromatography coupled with quadrupole time‐of‐flight massspectrometry. Journal of Separation Science 2019, 42: 3200-3208.
24.Liang, Y.; Zhou T.*. Recent advances of onlinecoupling of sample preparation techniques with ultra high performance liquidchromatography and supercritical fluid chromatography, Journal ofSeparation Science 2019, 42(1),226-242.
25.Yang, Y., Zhong, Q.,Zhang, H., Mo, C., Yao, J., Huang, T., Zhou,T. *, Tan, W*. Lipidomicsstudy of the protective effects of isosteviol sodium on stroke rats using ultrahigh-performance supercritical fluid chromatography coupling with ion-trap andtime-of-flight tandem mass spectrometry. Journal ofPharmaceutical and Biomedical Analysis, 2018, 157, 145-155.
26.Liang, Y., Liu, J.,Zhong, Q., Shen, L., Yao, J., Huang, T., Zhou,T. * Determination of major aromatic constituents in vanilla using anon-line supercritical fluid extraction coupled with supercritical fluidchromatography. Journal ofSeparation Science, 2018, 41(7), 1600-1609.
27.Y. Yang, J. Yang, H.Zhang, C. Mo, T. Zhou*, W. Tan*, The investigation of protectiveeffects of isosteviol sodium on cerebral ischemia by metabolomics approachusing ultra-high performance liquid chromatography coupled with quadrupoletime-of-flight tandem mass spectrometry, Biomedical Chromatography, 2018, 32(e435012), e4350.
28.Yang Yang, QishengZhong, Canlong Mo, Hao Zhang, Ting Zhou*,Wen Tan. Determination of endogenous inflammation-related lipid mediators inischemic stroke rats using background subtracting calibration curves by liquidchromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 2017, 409(28),6537-6547.
29.Zhou, Ting, Zeng, Jing, Zhao,Ting, Zhong, Qisheng, Yang, Yang, Tan, Wen, Enantioselective analysis ofbambuterol in human plasma using microwave-assisted chiral derivatizationcoupled with ultra high performance liquid chromatography and tandem massspectrometry. Journal of Separation Science, 2017, 40(13), 2779-2790.
30.Qisheng Zhong,Lingling Shen, Jiaqi Liu, Dianbao Yu, Simin Li, Jinting Yao, Song Zhan, TaohongHuang, Shinichi Kawano, Yuki Hashi, Zhaofeng Liu, Ting Zhou*. Pre-column dilution large volume injection ultra-highperformance liquid chromatography-tandem mass spectrometry for the analysis ofmulti-class pesticides in cabbages. Journalof Chromatography A, 2016, 1442, 53-61.
31.Qisheng Zhong,Lingling Shen, Jiaqi Liu, Dianbao Yu, Simin Li, Zhiru Li, Jinting Yao, TaohongHuang, Shin-ichi Kawano, Yuki Hashi, Ting Zhou*. Automaticon-line solid-phase extraction with ultra high performance liquidchromatography and tandem mass spectrometry for the determination of tenantipsychotics in human plasma. Journal of Separation Science, 2016, 39(11), 2129-2137.
32.T. Zhou, D. Zeng, T. Zhao, Y. Yang, S. Liu, J. Wu, L.Xu, W. Tan, In vivo metabolism study of (R)-bambuterol in humans using ultrahigh performance liquid chromatography with tandem mass spectrometry. Journalof Separation Science, 2016, 39(15), 2896-2906.
33.Ting Zhou, Jing Zeng, Shan Liu, et al. Study on the determinationand chiral inversion of R-salbutamol in human plasma and urine by liquidchromatography-tandem mass spectrometry. Journalof chromatography B, 2015, 1002, 218-227.
34.Ting Zhou, Shan Liu, Ting Zhao, et al. Chiral analysis of bambuterol, its intermediateand active drug in human plasma by liquid chromatography- tandem massspectrometry: application to a pharmacokinetic study. Journal ofchromatography B, 2015, 997: 38-44.
35.Qisheng Zhong,Xiongxiong Qiu, Caiyong Lin, Lingling Shen, Yin Huo, Song Zhan,Jinting Yao,Taohong Huang, Shinichi Kawano, Yuki Hashi, Langtao Xiao, Ting Zhou*. An automatic versatile system integrating solid-phaseextraction with ultra-high performance liquid chromatography–tandem massspectrometry using a dual-dilution strategy for direct analysis of auxins inplant extracts. Journal of ChromatographyA, 2014, 1359(23): 131-139.
36.Ting Zhou, Qing Cheng, Chengjuan Zou, Ting Zhao, Shan Liu, Marco Pistolozzi, Evina Tan, Ling Xu, Wen Tan.Simultaneousdetermination of bambuterol and its two major metabolites in human plasma byhydrophilic interaction ultra-performance liquid chromatography-tandem massspectrometry. Journal of chromatography B,2014, 967: 225-234.
37.Ting Zhou, Ting Zhao, Qing Cheng, Shan Liu, Ling Xu, WenTan. A sensitive LC-MS/MS method for simultaneous determination of R-bambuteroland its active metabolite R-terbutaline in human plasma and urine withapplication to a clinical pharmacokinetic study. Biomedical chromatography, 2014, 28(7): 994-1002.
38.Ting Zhou, Xiao-Hua Xiao,Gong-Ke Li. Microwave Accelerated Selective SoxhletExtraction for the Determination of Organophosphorus and Carbamate Pesticidesin Ginseng with Gas Chromatography/Mass Spectrometry. AnalyticalChemistry, 2012, 84(13): 5816-5822.
39.Ting Zhou, Xiao-Hua Xiao,Gong-Ke Li. Hybrid Field-AssistedSolid-Liquid-Solid Dispersive- Extraction for the Determination ofOrganochlorine Pesticides in Tobacco with Gas Chromatography. Analytical Chemistry, 2012, 84(1): 420-427.
40.Ting Zhou, Xiao-Hua Xiao, Jia-Yue Wang, Jin-Ling Chen,Xian-Fang Xu, Zhi-Feng He, Gong-Ke Li. Evaluation of microwave-assistedextraction for aristolochic acid from Aristolochiae fructus by chromatographicanalysis coupled with nephrotoxicity studies. Biomedical Chromatography, 2012, 26(2): 166-171.
41.Tong X, Zhou T, Xiao XH, Li GK. A consecutivepreparation method based upon accelerated solvent extraction and high-speedcounter-current chromatography for isolation of aesculin from Cortex Fraxinus. Journal of separation science, 2012, 35(24):3609-3614.
42.Ting Zhou, Xiao-Hua Xiao, Gong-Ke Li, Zong-wei Cai.Study of polyethylene glycol as a green solvent in the microwave-assistedextraction of flavone and coumarin compounds from medicinal plants. Journal of Chromatography A, 2011,1218(23): 3608-3615.
43.Ting Zhou, Li Ding, Xiaomin Li, Fei Zhang, Qian Zhang,Bing Gong, Xiaofeng Guo. Determination of iguratimod in rat plasma by highperformance liquid chromatography: method and application. Biomedical chromatography, 2008, 22(3): 260-264.
1. 周婷,黄敏涵,李悫. 基于微波辅助-MMPP环氧化技术的不饱和脂质异构体定性定量分析方法.专利申请号:202211616742.8
2. 周婷, 冯洁清, 金文彬. 大体积进样-变温聚焦超临界流体色谱质谱分析系统及分析方法. 授权专利号:ZL202110907049.5
3. 周婷, 金文彬. 超临界选择性脱水萃取-变压聚焦超临界流体色谱在线分析系统及分析方法. 授权专利号: ZL202010587498.1
4. 刘佳琪, 周婷, 梁艳珊, 钟启升, 黄涛宏. 固相脱水萃取-超临界流体色谱-质谱在线分析系统及方法. 授权专利号:ZL201910439461.1
5. 周婷, 曾晶, 谭文, 赵婷. 一种在线微波辅助手性衍生-液质联用分析系统及方法. 授权专利号:ZL201610329982.8
6. 李攻科, 周婷, 肖小华. 微波辅助索氏固相萃取联用装置、方法及应用. 授权专利号:ZL 201110380029.3