报告题目：Molecular and Macromolecular Hydrogels and Marginal Solubility (小分子和高分子水凝胶及微溶成胶条件)

报 告 人：蒙特利尔大学朱晓夏教授

报告时间：2023年3月24日上午9:00

报告地点：北区科技园2号楼324

广州国际校区师生：腾讯会议：863-881-399

前沿软物质学院

华南软物质科学与技术高等研究院

2023年3月21日

报告摘要：

Molecular and polymeric hydrogels are useful materials for a variety of applications including the biomedical and pharmaceutical fields. Bile acids are natural compounds exist in the body of human and most animals. In their salt form or after suitable chemical modifications, they can interact with each other in a specific solvent to form gels with self-assemble fibrous network, thus the molecular gels. These nanofibers are separated at low concentrations but entangle with each other at high concentrations to form hydrogels with well-dispersed and randomly-arranged 3D fibrous networks. The results point to a marginal solubility condition needed for gelation in water. The molecular hydrogels may be potentially useful in tissue engineering, cell culture, and mechano-optical sensing.

水凝胶是可应用于生物医学和制药行业等多种领域的软物质材料。胆汁酸是来自胆固醇的天然甾类化合物，通常以钠盐形式存在于动物体内，具有特殊的面双亲性，可形成柱状胶束，帮助消化油脂。经过适当化学修饰，胆酸及其衍生物在特定溶剂中通过自组装形成纤维网络，可成为小分子凝胶。这些分子在较高浓度的水溶液中通过氢键形成纳米纤维，进一步结合纠缠，形成分散良好且随机排列的3D纤维网络水凝胶。结果表明，在水溶液中需要达到微溶条件才能发生凝胶化。在某些情况下，二氧化碳也可成为有效的成胶剂，而且具有凝胶-解凝胶可逆变化等特点。小分子水凝胶在组织工程、细胞培养和生化传感方面都具有潜在的应用前景。

报告人简介：

Xiao-Xia Zhu is a professor of chemistry at University of Montreal. He holds the Canada Research Chair in Polymeric Biomaterials. His team works on the research and development of new polymers for biomedical and pharmaceutical applications, including degradable polymers, hydrogels, drug delivery systems and dental composites. His primary interests focus on the use of natural compounds for the preparation of novel polymeric materials with green chemistry approaches. He is a co-author of over 300 scientific publications and several patents. He also received the Macromolecular Science and Engineering Award from the Chemical Institute of Canada.

朱晓夏教授，南开大学化学系毕业，后获加拿大麦吉尔大学（McGill University）博士学位，现任蒙特利尔大学教授，并任生物医用高分子材料方面的Canada Research Chair。在降解性高分子、水凝胶、药物缓释和牙科材料有创新性研究，专注于利用天然化合物通过绿色化学方法制备新型高分子材料，发表学术论文300多篇和多项专利。他曾获得加拿大化学会高分子科学与工程奖。