Topic：Development of A Platform to Identify Molecular Target(s) of Small Molecules Based Therapeutics with Proteomics and Biophysical Binding Techniques

Speaker：Assistant Professor Hang Ma

Time：AM 09:00-11:30, 4th December, 2024

Venue：Dongtang Hall, BuildingNo.13, Wushan Campus

Welcome all theteachers and students to attend!

Abstract: 

A platform using a combination of proteomics (with data obtained from in vivo andin vitro models) and surface plasmon resonance (SPR) binding assays were developed to facilitate the identification of the molecular targets that areresponsible for the biological effects of small molecules. For instance, we utilized this platform to uncover the anti-inflammatory mechanisms of phenolic-enriched maple syrup extract in LPS-indued peritonitis in mice using data-independent acquisition proteomics analysis. In addition, the SPR technique was used to screen a library of natural products and FDA-approved drug chemicals for specific blockade effects on the interactions of immune checkpoints including PD-1/PD-L1.

About the speaker:

Hang Ma, Ph.D., is an Assistant Professor in the Department of Biomedical and Pharmaceutical Sciences at the College ofPharmacy of the University of Rhode Island (URI). He is the Director of the Bioactive Botanical Research Laboratory (BBRL) and the Head of the Research Unit for Nutraceutical and Cosmeceutical Applications (RUNCA) at URI. Dr. Ma received his Master's and Doctoral degrees in Pharmaceutical Sciences in 2011 and 2015 from URI, respectively. Dr. Ma has over 15 years of research experience in natural product chemistry. His research interests include the phytochemical and biological investigations of natural products from medicinalplants and functional foods for their nutraceutical and cosmeceutical applications. Dr. Ma has co-authored over 110 original peer-reviewed research articles, 4 review articles, and 1 international patent on novel botanical extracts for cosmetics.