Name: Wen Chen
Introduction: Professor
Email: wenchen@scut.edu.cn
PROFESSIONAL EXPERIENCE
·Tenured Professor, School of Food Science and Engineering, South China University ofTechnology, Guangzhou, China 07/2021-present
·Instructor/ResearchProfessor, Harvard Medical School, Boston, MA 10/2017-03/2021
·Post-doctoralfellow, Harvard Medical School, Boston, MA 10/2012-10/2017
·Part-timeAnalyst, Flagship Pioneering, Boston, MA 05/2013-02/2014
·Research Scientist, Hamilton College, Clinton, NY 05/2012-09/2012
·Internship, Merck & Co., Kenilworth, NJ 11/2011-05/2012
RESEARCH PROGRAMS
·(US) HealthAssistance Foundation,“Structural Biology of Amyloid BetaGeneration
·(US) NationalInstitute of Health,“Function and Mechanism of the Hcv P7Channel and Its Therapeutic Potential”
·(US) NationalInstitute of Health,“Structure-Function Studies of theMembrane-Interacting Domains Of Hiv-1 Env Spike ”
·(US) NationalInstitute of Health ,“Testing Novel Hypothesis In Mtu Reca Intein”
·(US) NationalScience Foundation,“Bridging Structure, Dynamics, and Functionin Antimicrobial Peptides”
·(US) NationalInstitute of Health ,“Membrane Protein Structures by Solution NMR”
·(US) NationalInstitute of Health ,“Molecular Architecture of the MitochondrialCalcium Uniporter
·(CN)Ministry ofScience and Technology，“Enzyme-catalyzed synthesis technology ofnutritional chemicals for green industry”
HONORS & AWARDS
·Certificateof Excellence, Bureau of Reclamation 2018
·Certificateof Honor, United States Department of Agriculture 2017
·Multiplewinning solver at INNOCENTIVE crowdsourcing competition 2016-2018
·OutstandingChinese research award, Harvard Medical School 2015
·JinshanResearch Excellence Award of Magnetic Resonance Society 2014
·Outstandinggraduate student award, Rensselaer Polytechnic Institute (2 in 150) 2012
·Graduatefellowship, Rensselaer Polytechnic Institute 2008
EDUCATION
·RensselaerPolytechnic Institute (RPI), Troy, NY 2006-2012
Ph.D in Biochemistry and Biophysics
·ChinaAgricultural University, Beijing, China 2003-2006
Bachelor Degree in Life Sciences
SELECTED PUBLICATIONS
1. Alessandro Piai,Qingshan Fu, Yongfei Cai, Fadi Ghantous, Tianshu Xiao, Md Munan Shaik, HanqinPeng, Sophia Rits-Volloch, Wen Chen, Michael S Seaman, Bing Chen, James J Chou. “Structural basis of transmembranecoupling of the HIV-1 envelope glycoprotein” Nature Communications, 2020,11;2317
2. Wen Chen, BoOuyang, James J Chou. “Critical Effect of the Detergent: Protein Ratio on theFormation of the Hepatitis C Virus p7 Channel” Biochemistry, 2019, 58(37), 3834-3837
3. Wen Chen, Junling Guo, Yongfei Cai, Bill Fu, James J Chou. “Unidirectional presentationof membrane proteins in nanoparticle-supported liposomes” Angewandte Chemie, 2019,58, 9866-9870 (with a cover Illustration)
4. Qingshan Fu*, Alessandro Piai*, Wen Chen*, Ke Xia, JamesChou. “Structure Determination Protocol for Oligomeric Transmembrane Domains” NatureProtocols, 2019, 14, 2483-2520 (Co-firstauthor)
5. Liqiang Pan⃰, Tianming Fu⃰, Linlin Zhao⃰, Wen Chen, Wenhui Liu, Zhijun Liu,Alessandro Piai, Qingshan FU, Shuqing Chen, Hao Wu, James J Chou. “Higher-OrderClustering of the Transmembrane Anchor of DR5 Drives Signaling” Cell,2019, 176 (6), 1477-1489. e14
6. Wen Chen, Bo OuYang, James Chou. “Re-evaluatingthe p7 viroporin structure reply” Nature, 2018 562, E19-E20
7. Wen Chen, Jyoti Dev, Julija Mezhyrova, Liqiang Pan, Alessandro Piai, James J Chou. “TheUnusual Transmembrane Partition of the Hexameric Channel of the Hepatitis CVirus” Structure. 2018, 26(4), 627-634, e4
8. Wen Chen, Wen Zeng, Jiansen Sun, Mingcan Yang, Li li, Jingting Zhou, Yangxiao Wu, JunSun, Ge Liu, Rui Tang, Ju Tan, Chuhong Zhu. “Construction of an aptamer–SiRNAchimera-modified tissue-engineered blood vessel for cell-type-specific captureand delivery” ACS Nano, 2015, 9 (6), 6069-6076
9. Wen Chen, Eric Gamache, David Rosenman, XieJian, Lopez Marimar, Yue-Ming Li, Chunyu Wang. “Familial Alzheimer's mutationswithin APPTM increase Aβ42 production by enhancing accessibility of ε-cleavagesite” Nature Communications, 2014 Jan 6;5:3037
10. Wen Chen,Myriam Cotton. “Expression, purification, and micelle reconstitution ofAntimicrobial Piscidin 1 and Piscidin 3 for NMR studies” Protein Expr Purif, 2014Oct, 102: 63-68.
11. Wen Chen, Lingyun Li, Zhenming Du, JiajingLiu, Julie N. Reitter, Kenneth V. Mills, Robert J. Linhardt, and Chunyu Wang.“Intramolecular Disulfide Bond between Catalytic Cysteines in an InteinPrecursor” J. Am. Chem. Soc., 2012, 134 (5),pp 2500–2503
12. Wen Chen, EricGamache, Danielle Richardson, Zhenming Du, and Chunyu Wang.“Expression,purification, and reconstitution of the transmembrane domain of the humanamyloid precursor protein for NMR studies” Protein Expr Purif, 2012 Jan;81(1):11-7
SCIENTIFIC PEER REVIEWING
Served as scientific reviewer for PLOS Computation Biology Bioinformatics
Journal of Neurochemistry PLOS One Biochemistry
Molecular BioSystems Journal of Biomolecular Structrue & Dynamics BioMed Research
International Journal of Molecular Sciences
Journal of Theoretical Biology Medicinal Chemistry Biotechnology and Applied Biochemistry
Journal of Biophysics BBA-Biomembranes
