Lecture by Dr. Yonggui Gao from Nanyang Technological University
 
time: 2019-09-03

Venue: Dongtang Hall, Building 13

Time: Sep.10, Tuesday, 09:30AM

Lecture: Antimicrobial resistance: an emergent issue and the strategy
Speaker: Yonggui Gao (Nanyang Technological University)


    Welcome all the teachers and students to attend

 

Executive Summary

The ribosome, a protein synthesizing machine, is one of the richest targets for over half of clinically used antibiotics. We have determined several structures of ribosome complexes that offers insight into action mechanism of antibiotic as well as rationalizes mutations resulting in resistance. On the other hand, antibiotic could help us trap ribosome in certain state so that the structure can be reconstructed and visualized.

       Current antibiotic resistance crisis urgently requires a better understanding of drug resistance mechanisms and effectively targeted drug discovery. A wide range of mechanisms could mediate antibiotic resistance, which is currently one of the biggest threats to global health and food security. Recently, we identified a few ATP-binding cassette family proteins that can confer resistance across species to various antibiotic classes through unknown mechanisms. Elucidating these mechanisms will enable us to rational design improved antimicrobial agents that overcome multidrug-resistant bacteria. Here I will be presenting our recent progress towards a better understanding of action mechanisms of antibiotic and drug resistance involving ribosome protection.