Name: Wen-Yong Lou
Introduction: Professor, Vice-Dean
School of Food Science and Engineering
Tel: 020-87111219
Fax: 0086-20-87111219
E-mail: wylou@scut.edu.cn
Education Background
1995.9~1999.7 B.S. in Biotechnology, Hubei University of Technology;
1999.9~2002.3 M.S. in Fermentation Engineering, South China University of Technology;
2002.9~2005.6 Ph.D. in Biochemical Engineering, South China University of Technology.
2008.5~2008.8 Visiting Scholar in University of Warwick, England.
Employment Summary
Vice-Dean (2016– present):School of Food Science and Engineering, South China University of Technology.
Professor (2012- present): School of Food Science and Engineering, South China University of Technology
Associate professor (2009-2012): College of Light Industry and Food science, South China University of Technology.
Lecture (2005-2008): College of Light Industry and Food science, South China University of Technology.
Field of Research
1. Food Bio-Fabrication andProcess Control
2. Food Safety, Nutrition and Health
3. Encapsulation and Targeting Deliveryof Bioactive Ingredients
Current Research Projects
1. Intensive strategies for the effectivecatalysis of immobilized enzyme, The National Key Research and DevelopmentProgram of China, 2021YFC2102804.
2. The biosynthesis of bioactivepolysaccharides and its modulated mechanism in endophytic fungi of Millettiaspeciosa Champ plant, The National Natural Science Foundation of China,22078111.
3. The construction of engineeredE. coli to enhance the resistance against phage attack via metabolicengineering technology, The National Natural Science Foundation of China,21878105.
4. The hydrolytic mechanism ofsynthetic lipase and its applications on the synthesis of aromatic aldehydederivatives, The National Natural Science Foundation of China, 22378146.
5. The targeted excavation ofcontrollable biotransformed-lipid enzyme and its stable modification atmolecular level. The National Key Research and Development Program of China(Sub-project), 2022YFD210140.
6. Online quality control systemfor food safety and inspection, The National Key Research and DevelopmentProgram of China (Sub-project), 2018YFC1603400.
7. The asymmetric hydrolysis ofepoxides catalyzed by epoxide hydrolase in deep eutectic solvent, The NationalNatural Science Foundation of China, 21676104.
8. Excavation of bioactiveingredients from Millettia speciosa Champ plant and their applicationswith high economic value, The Key Research and Development Program of Guangzhoucity, 2060404.
9. The biosynthesis of activeingredients for food application, its structure-activity relationships andtargeted delivery, The Central University Basic Scientific Research:Interdisciplinary Project, 2022ZYGXZR10.
10.Biocatalysis and biomass transformation in novel nonaqueousmedium, The National Science Foundation of China for Outstanding YoungScholars, 21222606.
11.Research on the innovate technologies and industrialization of nutprocessing, The University-Enterprise Cooperation Project, D820392.
12.The Omega fatty acids in macadamia nut: their extraction,enrichment, microencapsulation and functionality, University-EnterpriseCooperation Project, D8223060.
13.Research on the comprehensive utilization of raw Millettiaspeciosa Champ plant, The University-Enterprise Cooperation Project,D8183870.
14.Production of bioactive polysaccharides from the endophytic fungusof Dendrobium officinale plant, The Science and Technology Project ofGuangzhou City, 201904010360.
15.Mechanical study on the proliferation, differentiation andmineralization of (pre-) osteoblasts treated by colostrum-containing basicprotein products, The University-Enterprise Cooperation Project, D9222190.
16.Research on the efficient extraction and processing technology ofcrucial active ingredient of Sturgeon, The University-Enterprise CooperationProject, D8224040.
17.A microbial strain enables chitinase production via thefermentation of crab shells, The University-Enterprise Cooperation Project,F3210260.
18.Research on the cultivation of Millettia speciosa Champ andits deeply processing technology, The Enterprise-University-Institute Cooperation Project of Guangdong Province, B8200070.
Publications（* as corresponding author）
1. Yuan, X.; Wu, X.L.*; Xiong, J.; Yan, B.H.; Gao,R.C.; Liu, S.L.; Zong, M.H.; Ge, J.*; Lou, W.Y.*, Hydrolase mimic viasecond coordination sphere engineering in metal-organic frameworks forenvironmental remediation, Nature Communications, 2023, 14, 5974
2. Liu, S.L.; Zhou, J.T.; Yuan, X.; Xiong, J.;Zong, M.H.; Wu, X.L.*; Lou, W.Y.*,A dual-mode sensing platform based onmetal-organic framework for colorimetric and ratiometric fluorescent detectionof organophosphorus pesticide, Food Chemistry, 2023, 432, 137272.
3. Xiong, J.; Chen, B.; Gu, Z.Y.; Liu, S.L.; Zong,M.H.; Wu, X.L.*; Lou, W.Y.*, Hierarchically open-capsule metal-organicframeworks via controlled etching for enzyme encapsulation. ChemicalEngineering Journal, 2023, 468, 143622.
4. Li, M.F.; Cui, H.L.; Lou, W.Y.*,Millettia speciosa Champcellulose-based hydrogel as a novel delivery system for Lactobacillus paracasei: Itsrelationship to structure, encapsulation and controlled release. Carbohydrate Polymers,2023, 316, 121034
5. Li, M.F.; Wu, X.L.; Guo, Z.W.; Gao, R.C.; Ni, Z.F. ; Cui, H.L.; Zong, M.H.; Van Bockstaele, F.; Lou,W.Y.*,Lactiplantibacillus plantarum enablesblood urate control in mice through degradation of nucleosides ingastrointestinal tract. Microbiome, 2023, 11(1), 153.
6. Liu, S.L.; Wu, X.L.*; Xiong, J.; Yuan, X.; Zong, M.H.; Lou, W.Y.*, Aspartic acid based metal–organic frameworkswith dual function of NADH peroxidase and glycerol dehydrogenase-mimickingactivities. Materials ChemistryFrontiers, 2022, 6, 3391.
7. Huang, Z.; Zong, M.H.; Lou, W.Y.*, Effect of acetylationmodification on the emulsifying and antioxidant properties of polysaccharidefrom Millettia Speciosa Champ. Food Hydrocolloids, 2022,124, 107217.
8. Huang, Z.; Zeng, Y.J.; Wu, X.L.; Li, M.F.;Zong, M.H.; Lou, W.Y.*, Development of Millettia speciosa champ polysaccharide conjugatestabilized oil-in-water emulsion for oral delivery of β-carotene:Protection effect and in vitro digestion fate. Food Chemistry, 2022, 397,133764.
9. Qi, L.; Lei, J.Q.; Gao, Q.Y.; Zhang, B.*; Lou, W.Y.*; Luo, Z.G., Surfactant-assistedsynthesis of colloidosomes for positional assembly of a bienzyme system. Chemical Engineering Journal,2022, 452, 139305.
10. Chen, Y.Z.; Xu, X.J.; Qi, L.*; Lou, W.Y.*; Luo, Z.G., Designing a highlystable enzyme−graphene oxide biohybrid as a sensitive biorecognition module forbiosensor fabrication with superior performance and stability. ACS Sustainable Chemistry & Engineering, 2022,10, 2971.
11. Huang,Z.; Zong, M.H.; Lou, W.Y.*,Preparation,structural elucidation and immunomodulatory activity of a polysaccharide from MillettiaSpeciosa Champ. Industrial Crops & Products, 2022,182, 114889.
12. Huang,Z.; Li, N.; Xu, P.; Guo, Z.W.; Zong, M.H.; Lou, W.Y.*,Enhancement of thermostabilityand catalytic properties of ammonia lyase through disulfide bond constructionand backbone cyclization. International Journal ofBiological Macromolecules, 2022, 219, 804.
13. Liang, S.; Wu, X.L.; Xiong, J.; Yuan, X.; Liu,S.L.; Zong, M.H.; Lou, W.Y.*, Multivalent Ce-MOFs as biomimetic laccase nanozyme for environmentalremediation. Chemical EngineeringJournal, 2022, 450, 138220.
14. Liang, S.; Wu, X.L.; Zong, M.H.; Lou, W.Y.*, Constructionof Zn-heptapeptide bionanozymes with intrinsic hydrolase-like activity fordegradation of di(2-ethylhexyl) phthalate. Journal of Colloid andInterface Science, 2022, 622, 860.
15. Zhang,Z.H.; Gu, Z.Y.; Li, M.F.; Liang, S.; Huang, Z.; Zong, M.H.; Wu, X.L.*; Lou, W.Y.*, Oxidized high-amylose starch aspickering stabilizer for oil-in-water emulsion and delivery of bioactivecompound. Food Hydrocolloids for Health, 2022,2, 100104.
16. Li, M.F.; Cui, H.L.; Liu, S.Y.; Bockstaele,F.V.; Yu, M.*; Lou, W.Y.*, Theantioxidative capacities of Lactobacillus and its potential mechanisms via chemicaland cellular assessments. International Journal of FoodScience and Technology, 2022, 57, 7340.
17. Li, N.; Ni, Z.F.; Guo, Z.W.; Xia, H.; Xu, P.;Jiang, Y.B.*; Lou, W.Y.*, Enhancedconversion and extraction of ginsenoside Rg1 from Panax notoginseng usingβ-xylosidase mutants and an endoxylanase. Industrial Crops &Products, 2022, 187, 115514.
18. Guo, Z.W.; Ni, Z.F.; Zong, M.H.; Lou, W.Y.*, Modular metabolic engineering of Bacilluslicheniformis for efficient 2,3-butanediol production by consolidated bioprocessingof Jerusalem artichoke tubers. ACS Sustainable Chemistry & Engineering, 2022, 10, 9624.
19. Chen, Q.S.; Yuan, X.; Peng, F.; Lou, W.Y.*, Immobilizationof engineered E. coli cells for asymmetric reduction of methylacetoacetate to methyl-(R)-3-hydroxybutyrate. Bioresources and Bioprocessing,2022, 9, 19.
20. Zhang, L.S.*; Liu, R.B.; Zong, M.H.; Yang,J.G.; Lou, W.Y.*; Bi,Y.L., A comparative study of human milk fat substitute from Rhodococcusopacus and plant-oil based commercial products. Food Bioscience, 2022,50, 102031.
21. Wu,X.L.*; Xiong, J.;Liu, S.L.; Zong, M. H.; Lou, W. Y.*, Aversatile competitive coordination strategy for tailoring bioactive zeoliticimidazolate framework composites. Small, 2021, 17,2007586.
22. Xu, P.; Liang, S.; Zong, M. H.; Lou, W. Y.*,Ionic liquids for regulating biocatalytic process: achievements andperspectives. Biotechnology Advances, 2021, 29, 107702.
23. Wu,X.L.; Xiong, J.; Liu, S.L.; Cheng J.H.; Zong, M. H.; Lou, W.Y.*, Investigation ofhierarchically porous zeolitic imidazolate frameworks for highly efficient dyeremoval. Journal of Hazardous Materials, 2021, 417, 126011.
24. Chen X.; Huang, Z.; Luo, S.Y.; Zong, M.H.; Lou,W.Y.*, Multi-functional magnetic hydrogels based on millettia speciosachamp residue cellulose and chitosan: highly efficient and reusable adsorbentfor congo red and cu 2+ removal. Chemical Engineering Journal, 2021,423, 130198.
25. Zhang, Z.H.; Li, M.F.; Peng, F.; Zhong, S.R.; Huang, Z.;Zong, M.H.; Lou, W.Y.*,Oxidized high-amylose starch macrogel as anovel delivery vehicle for probiotic and bioactive substances. Food Hydrocolloids, 2021,114, 106578.
26. Zhong, S.R.; Li, M.F.; Zhang, Z.H.; Zong, M.H.;Wu, X.L.; Lou, W.Y.*, Novelantioxidative wall materials for Lactobacillus casei microencapsulationvia the Maillard reaction between the soy protein isolate and prebioticoligosaccharides. Journal of Agricultural and FoodChemistry, 2021, 69,13744.
27. Peng, F.; Chen, Q.S.; Zong,M.H.; Lou, W.Y.*,Sequential co-immobilization of multienzyme nanodevices based on SpyCatcher andSpyTag for robust biocatalysis. Molecular Catalysis, 2021,510, 111673.
28. Ni, Z.F.; Xu, P.; Zong, M.H.; Lou, W.Y.*, Structure-guided proteinengineering of ammonia lyase for efficient synthesisof sterically bulky unnatural amino acids. Bioresources and Bioprocessing,2021, 8, 103.
29. Xu, P.; Zhang, S.Y.; Luo, Z.G.; Zong, M.H.; Lou,W.Y.*, Biotechnology and bioengineering of pullulanase: state of the artand perspectives. World Journal of Microbiology and Biotechnology, 2021,37, 43.
30. Zhang,L.S.; Chu, M.Y.; Zong, M.H.; Yang, J.-G.; Lou,W.Y.*, Facile and greenproduction of human milk fat substitute through rhodococcus opacusfermentation. Journal of Agricultural and Food Chemistry, 2020, 68, 9368.
31. Liang, S.; Wu, X.L.; Xiong, J.; Zong, M.H.; Lou, W.Y.*,Metal-organic frameworks as novel matrices for efficient enzyme immobilization:An update review. Coordination Chemistry Reviews, 2020, 406, 213149.
32. Guo,Z.W.; Ou, X.Y.; Xu, P.; Gao,H.F.;Zhang, L.Y.; Zong, M.H.; Lou,W. Y.*, Energy- and cost-effective non-sterilized fermentation of2,3-butanediol by an engineered Klebsiella pneumoniae OU7 with ananti-microbial contamination system. Green Chemistry, 2020, 22, 8584.
33. Guo,Z.W.; Ou, X.Y.; Liang, S.; Gao,H.F.; Zhang, L.Y.; Zong, M.H.; Lou, W.Y.*, Recruitinga phosphite dehydrogenase/formamidase-driven anti-microbial contaminationsystem in bacillus subtilis for non-sterilized fermentation of acetoin. ACSSynthetic Biology, 2020, 9,2537.
34. Ni,Z.F.; Zeng, Y.J.; Xu, P.; Guo, Z.W.; Ou, X.Y.; Peng, F.; Yang, J.G.; Zong,M.H.; Lou, W.Y.*, Characterization of a novel methylaspartate ammonialyase from E. coli O157:H7 for efficient asymmetric synthesis ofunnatural amino acids. ACSSustainable Chemistry & Engineering, 2020, 8, 329.
35. Su,H.H.; Peng, F.; Ou, X.Y.; Zeng,Y.J.; Lou, W.Y.*, Combinatorial synthetic pathway fine-tuning andcofactor regeneration for metabolic engineering of escherichia colisignificantly improve production of d-glucaric acid. New Biotechnology, 2020,59, 51.
36. Xu, P.; Ni, Z.F.; Zong, M.H.; Ou, X.Y.;Yang, J.G.; Lou, W.Y.*, Improving the thermostability and activity of Paenibacilluspasadenensis chitinase through semi-rational design.InternationalJournal of Biological Biomacromolecules, 2020, 150, 9.
37. Liang, S.; Wu, X.L.; Zong, M.H.; Lou, W.Y.*, Zn-triazole coordination polymers: Bioinspired carbonic anhydrase mimicsfor hydration and sequestration of CO2. Chemical EngineeringJournal, 2020, 398, 125530.
38. Huang, Z.; Zeng, Y.J.; Chen, X.; Luo, S.Y.; Pu, L.; Li, F.Z.; Zong, M.H.;Lou, W.Y.*, A novel polysaccharide from the roots of Millettia SpeciosaChemp: preparation, structural characterization and immunomodulatory activity. InternationalJournal of Biological Biomacromolecules, 2020, 145, 547.
39. Wu, X.L.; Xiong, J.; Liu, S.L.; Chen, B.; Liang, S.; Lou, W.Y.*; Zong,M.H., Peroxidase encapsulated in peroxidase Mimics via in situ assembly withenhanced catalytic performance. ChemCatChem, 2020, 12, 1.
40. Su, H.H.; Guo, Z.W.; Wu, X.L.; Xu, P.; Li, N.; Zong, M.H.; Lou, W.Y.*,Efficient bioconversion of sucrose to high-value-added glucaric acid by invitro metabolic engineering. ChemSusChem,2019, 12, 2278.
41. Ou, X.Y.; Wu, X.L.; Peng, F.; Zeng, Y. J.; Li, H. X.; Xu, P.; Chen, G.;Guo, Z.W.; Yang, J.G.; Zong, M. H.*; Lou, W.Y.*, Metabolic engineeringof a robust Escherichia coli strain with a dual protection system. Biotechnology and Bioengineering, 2019,116, 3333.
42. Zeng,Y.J.; Yang, H.R.; Zong, M.H.; Yang, J.G.; Lou, W.Y.*, Novelantibacterial polysaccharides produced by endophyte Fusarium solani DO7.BioresourceTechnology, 2019, 288, 121596.
43. Wu, X.L.; Huang, Z.X.; Cao, S.L.; Zong, M.H.; Lou, W.Y.*,Improving biocatalysis of cefaclor with penicillin acylase immobilized onmagnetic nanocrystalline cellulose in deep eutectic solvent based co-solvent. Bioresource Technology, 2019, 288, 121548.
44. Xu, P.; Wu, X.L.; Guo, X.X.; Tang, J.; Zong, M.H.; Lou, W.-Y.*,Double-chitinase hydrolysis of crab shell chitin pretreated by ionic liquid togenerate chito-oligosaccharide. ACS Sustainable Chemistry &Engineering, 2019, 7, 1683.
45. Zeng, Y. J.; Yang, H. R.; Wu, X. L.; Peng, F.; Huang, Z.; Pu, L.; Zong,M. H.; Yang, J. G.; Lou, W.Y.*, Structure and immunomodulatory activityof polysaccharides from Fusarium solani DO7 by solid-state fermentation.International Journal of Biological Biomacromolecules, 2019, 137, 568.
46. Zeng, Y.J.; Yang, H.R.; Wang, H.F.; Zong, M.H.; Lou, W.Y.*, Immuneenhancement activity of a novel polysaccharide produced by Dendrobiumofficinale endophytic fungus Fusarium solani DO7. Journal of Functional Foods, 2019, 53, 266.
47. Zeng, Y.J.; Yang, H.R.; Ou, X.Y.; Su, H.H.; Zong, M.H.; Yang, J.G.; Lou,W.Y.*, Fungal polysaccharide similar with host Dendrobium officinalepolysaccharide: Preparation, structure characteristics and biologicalactivities. International Journal of Biological Biomacromolecules, 2019,141, 460.
48. Wei, P.; Guo, Z.W.; Wu, X.L.; Zong, M.H.; Lou, W.Y.*,Significantly enhancing the biocatalytic synthesis of chiral alcohols bysemi-rationally engineering an anti-Prelog carbonyl reductase from Acetobactersp. CCTCC M209061. Molecular Catalysis, 2019, 479, 27.
49. Zeng, Y.J.; Xu, P.; Yang, H.R.; Zong, M.H.; Lou, W.Y.*,Purification of anthocyanins from saskatoon berries and theirmicroencapsulation in deep eutectic solvents. LWT--Food Science and Technology,2018, 95, 316.
50. Huang, Z.X.; Cao, S.L.; Xu, P.; Wu, H.; Zong, M.H.; Lou, W.Y.*,Preparation of a novel nanobiocatalyst by immobilizing penicillin acylase ontomagnetic nanocrystalline cellulose and its use for efficient synthesis ofcefaclor. Chemical Engineering Journal, 2018, 346, 361.
Professional Activities
1.Guangdong Youth Association of Young Scientists, Member.
2. National Natural Science Foundation of China, Project review expert.
3. Guangdong Provincial Pharmaceutical Association, Member.
4.Frontiers in Bioengineering andBiotechnology, Associate Editor-in-Chief.
5. Frontiersin Microbiology, Associate Editor-in-Chief.
6. Bioresources and Bioprocessing, EditorialBoard Member.
7. Food Science and Technology (ChineseJournal), Editorial Board Member.
Awards
1. Excellent Research Advisor asthe AGFD Virtual Asia-Pacific Graduate Students Symposium at ACS Fall 2023
2. Science and TechnologyOutstanding Contribution Award of China Petroleum and Chemical IndustryFederation for Youth, 2018
3. Gold Award of International GeneticalEngineered Machine Competition (iGEM), 2017
4. Science and Technology ofGuangdong Province in Natural Science, Second Price, 2014
5. Outstanding Youth ScienceFoundation of National Natural Science Foundation of China, 2012
6. NewCentury Outstanding Talents Support Program of Ministry ofEducation, 2010
7. Award of National ExcellentDoctoral Dissertation of China, 2009
Courses Offered
1. “Food Microbiology Experiment” for undergraduate students.
2. “Bio-synthesis and Bio-transformation” for graduate student.
