Name: Ling Fei Gender: Female
Date : 1972. 10 Title: Professor
Contact: 13642688144
Education background and research experience:
In 1995, he received a bachelor's degree in zoology from the School of Life Sciences, Sun Yat-sen University. From 1999 to 2000, he started his postgraduate course in biochemistry and molecular biology at the College of Life Sciences, South China Normal University. In 2004 and 2008, he obtained the Animal Genetics of South China Agricultural University Master, PhD, respectively, under the tutelage of Professor Hu Jiaqi from South China Agricultural University and Professor Chen Xiaosheng of Sun Yat-sen University. August 2008 to December 2010, in the South China University of Technology School of Life Science and Engineering in postdoctoral research, under the tutelage of Professor Wang Xiaoning immunology experts, is now the People's Liberation Army General Hospital Institute of Geriatric Basic Research Institute. January 2011 to stay in school and promotion of associate researchers, due to excellent work in 2012 and 2015 has promoted the first post researcher and the first post professor, promoted in September 2016 as a professor. Under the support of the China Scholarship Council, the Josh Akey group of Genomics Department of the University of Washington School of Medicine, known as the cradle of genomics science, was held from 2013 to 2014. The genetic variation of the genome of primates was Type of variation / disease.
Teaching and postgraduate training experience:
Speaking of biotechnology classes common biology and molecular genetics two professional basic courses and compulsory courses, won the 2014-2015 undergraduate teaching excellence award. Has successfully completed the six graduate students graduate thesis guidance and assistance to guide a doctoral student graduation and guide more than 20 undergraduate students graduation thesis design. Among them, the two undergraduate students for two consecutive years, 2013, 2014 national scholarships, two scholarships, and one of the graduate was awarded the outstanding graduate students in Guangdong Province, the title; In addition, seriously and actively guide the undergraduate declaration of various types of institutions School-level scientific research projects, successfully obtained 2012, 2013, 2014 annual biology college undergraduate innovation fund project and funding; also guide the first and second grade undergraduates actively participate in summer practice, and won the first prize. At the same time, due to the excellent work of the class teacher, also won the 2013 South China University of Technology outstanding class teacher title; 2014-2015 academic year second semester undergraduate classroom teaching quality excellent teachers.
Research areas:
The main research areas are animal molecular genetics, comparative and evolutionary genomics, immunogenetics, epigenetics, the main research direction is: 1) to carry out primate host restriction factor TRIM5α and MHC polymorphism and major diseases (2) the use of bioinformatics, epigenetics, evolutionary genomics methods, and the use of bioinformatics, epigenetics, evolutionary genomics, and the use of bioinformatics, epigenetics, evolutionary genomics , To study the relationship between primitive genome regulatory region variation, evolution and phenotypic variation of major disease susceptibility.
Achievements:
Presided over the National Natural Science Foundation of a project, as a sub-task task completion of the National Science and Technology Support Program sub-project one, but also presided over the Provincial Department of Education, a major provincial project, the Chinese postdoctoral fund, the Guangdong Provincial Natural Science Foundation, Guangdong Province science and technology project, the central university basic scientific research business fee surface projects, key projects and rolling projects and other issues. Participate in a national fund key project.
Over the past five years has published more than 30 SCI papers (the first author or author of the communication published SCI article 20, the total impact factor 91, single quote 118 times). The first or communication author's thesis in Nature Biotechnology, Proceedings of the Royal Society B-Biological Sciencs (Top), Scientific reports (biology), virology, PLoS One, Tissue antigen, American journal of Primatology, Immunogenetics, human immunology, Molecular Biology Report, DNA and Cell Biology, Molecular and cell biochemistry, Biochemical and Biophysical Research Communications. A genuational sequencing and comparisons of two cynomolgus monkeys and Chinese rhesus monkeys have been published online in 2011 in Nature Biotechnology (Impact Factor 43). The achievement of the major achievements of the South China University of Technology Institute of Biology teachers aspirations to the natural series of zero breakthrough. The acquisition of the research results is another important stage result of the monkey genetic background work framework, which provides important reference materials for the research and research of new drugs and the research of basic medicine. It also laid the foundation for the research of evolutionary medicine. On this basis, I was studying at the University of Washington in the United States during the top team in the field Josh Akey team, through the primate genome MHC region DHSs comparison, evolution analysis and integration with the GWAS database found that, in addition to host-pathogen interaction and reproductive adaptation In addition, brain development and cognitive ability is also driving the evolution of human MHC, and from the causal relationship mining and confirmed the MHC's existing and potentially new features. In addition, by comparing the sperm methylation group and the genome of two Rattus norvegicus subspecies in China, it was proved that the difference of genomic methylation caused by stable environmental difference (interspecific environmental difference) could be inherited between generations, The relationship between the acquisition of Ramak and Darwin 's natural selection theory is clarified, and a new explanation is given to the mechanism of species differentiation.
The following is a representative paper published nearly five years:
1.Xiang R, Zhang H, Deng Q, Yue R, Tang H, Zhang Y, Ling F, Zhuo M, Du H, Xu S, Xu Q, Wang X. Comprehensive identification of high-frequency and co-occurring Mafa-DPA1, Mafa-DQA1, Mafa-DRA, and Mafa-DOA alleles in Vietnamese cynomolgus macaques.Immunogenetics. 2013 Sep;65(9):667-74. (corresponding author）
2.He DD, Lu Y, Gittelman R, Jin Y, Ling F, Joshua A. Positive selection of the TRIM family regulatory region in primate genomes. Proc Biol Sci. 2016 Oct 12;283(1840). pii: 20161602. (corresponding author）(if:4.823)
3.Zheng Su, Junjie Zhang, Chanchal Kumar, Cliona Molony, Hongchao Lu, Ronghua Chen, David J. Stone, Fei Ling and Xiao Liu. Species-specific exome probes reveal new insights in positively selected genes in nonhuman primates. Sci Rep. 2016 Sep 23;6:33876. doi: 10.1038/srep33876. (corresponding author）二区(if:5.228)
4.Hui-Ling Zhang , Feng-Liang Liu , Ya-Bin Jin, Qing Deng, Bei-Lei Liu, Min Zhuo, Xiao-Hui liu, Yong-Tang Zheng, Fei Ling. The effects of TRIM5α polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques. Virology, Volume 487, January 2016, Pages 222–229 (corresponding author）(if:3.2)
5.He DD, Mao ShL, Wang W, Jin YB, Zhang HL, Ling F. SAMHD1 Polymorphisms were Significantly Correlated with HIV/SIV Virus Load in PBMC from Chinese Rhesus Macaques and Cynomolgus Macaques. Curr HIV Res. 2016 Oct 18. [Epub ahead of print](corresponding author）
6.W. Wang, D.-D. He, S.-L. Mao, M. Zhuo, F. Ling. Ten novel MHC class II alleles identified in cynomolgus macaques of Vietnamese origin. Tissue Antigens HLA. 2016 Feb;87(2):115-6. doi: 10.1111/tan.12731. Epub 2016 Jan 13 (corresponding author）
7.Chen M, Song P, Zou D, Hu X, Zhao S, Gao S, Ling F. Comparison of multiple displacement amplification (MDA) and multiple annealing and looping-based amplification cycles (MALBAC) in single-cell sequencing. PLoS One. 2014 Dec 8;9(12)(corresponding author)
8.Wang W, Lu YE, Zhuo M, Ling F. Identification of five novel MHC class II alleles in cynomolgus macaques of Vietnamese origin. HLA. 2016 Jul;88(1-2):61-2. doi: 10.1111/tan.12840. Epub 2016 Jul 8(corresponding author)
9.Liu B, Jin Y, Lu Y, Wu Y, Xue Y, Zhang Y, Liu Y, Zhuo M, Ling F.Comprehensive identification of high-frequency and combination MHC-DMA and -DMB alleles in a cohort of Chinese rhesus macaques and cynomolgus macaques of Vietnamese origin. Hum Immunol. 2015 Mar;76(2-3):109-12.(corresponding author)
10.Zhang H, Deng Q, Jin Y, Liu B, Zhuo M, Ling F. Comprehensive identification of MHC class II alleles in a cohort of Chinese rhesus macaques.Immunogenetics. 2014 Oct; 66(9-10):575-80. doi: 10.1007/s00251-014-0789-y. Epub 2014 Jul 22 (corresponding author)
