Publications

Publications

148. Xiang Gao, Rui Wu*, Shifa Zhu*, Dimolybdenum Catalysis: Deoxygenative Coupling of Aldehydes, J. Org. Chem. 2025, 90, 10465-10475. (Invited for Celebrating Nankai University's Legacy of Excellence in Organic Chemistry)


147. Zurong Xu, Jiajun Lu, Rui Wu, Shifa Zhu*, Rh2(II)-catalyzed cyclization/gem-hydrosilylation of benzene-fused 1,6-enynones, Org. Chem. Front.2025, In Press. DOI: 10.1039/d5qo00835b.


146. Dacheng Shen, Liang Chen, Shaoming Wu, Kun Chen, Dongming Qi, Shifa Zhu*, Fibrillation in Lyocell: Chemical Insights, Engineering Solutions and Emerging Challenges, Carbohyd. Polym. 2025, 363, 123722. DOI: 10.1016/j.carbpol.2025.123722  


145. Xin Yu, Shifa Zhu*, Recent Progress on Catalytic Transformation of Acetylene, Chem. Soc. Rev. 202554, 5586-5618. DOI: 10.1039/d4cs00729h


144. Ke Yu, Tongxiang Cao,* Shifa Zhu,* Claisen rearrangement enabled efficiently access to biaryl phenols, Org. Biomol. Chem. 2025, 23, 4879. DOI: 10.1039/D5OB00468C.


143. Jialin Wang, Mingluo He, Tongxiang Cao,* Shifa Zhu*, Pyrone Isomerization Enabled Divergent Access to Multisubstituted Biaryl Phenol via Relay Claisen Rearrangement, Org. Lett. 2025, 27, 4865-4869. DOI: 10.1021/acs.orglett.5c01077.

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142. Yang Chen, Jiayan Chen, Shifa Zhu*, Rh(I)-Catalyzed Modular Synthesis of Axially Chiral Alkylidene Azacycloalkanes, ACS Cent. Sci. 2025, 11, 899-909. DOI: 10.1021/acscentsci.5c00232. (Highlighted by Synfacts, 2025, 21, 811.)


141. Chuntao Wang, Zi-Hao Liao, Rui Wu*, Kai Chen*, Shifa Zhu*, Enantioselective Synthesis of 1-Dihydrobenzazepines through Rh2(II)-Catalyzed Cycloisomerization of 1,6-Enyne, J. Am. Chem. Soc. 2025, 147, DOI: 10.1021/jacs.5c00053.


140. Tairan Cheng, Siju Li, Jiaoyao Qiu, Zedong Yang, Huanfeng Jiang, Shifa Zhu*,Homologation of Alkenes Using Acetylene as a C2 Feedstock, Angew. Chem. Int. Ed. 202564, e202425169. DOI: 10.1002/anie.202425169


139. Jiamin He, Wenjun Liu, Jialin Wang, Penghui Yan, Tongxiang Cao*, Shifa Zhu*, Gold-catalyzed 1,2-rearrangement on benzene triggered by a transient dearomative Claisen rearrangement, Org. Lett. 2025, 27, 2734-2740. DOI: 10.1021.orglett.5c00510. 


138. Yi Xiong, Zhu-Wen Wei, Jin-Shi Li, Ping-Chuan Shen, Ben-Zhong Tnag, Shi-Fa Zhu*, Zu-Jin Zhao*, Improving single-molecule conductance by the quinoid structure of furan derivatives, Rare Metals, 2025, 44,  4061-4073. DOI: 10.1007/s12598-024-03187-6. 

 


137.  Xianyang Long, Dong Zhu*, Shifa Zhu*, Cobalt-Catalyzed Chemoselective and Divergent Synthesis of Vinylsilanes through Hydrosilyation of Acetylene, ACS Catal.2025, 15, 4429-4440. DOI: 10.1021/acscatal.5c00006



136. Hao Ruan, Dong Zhu*, Jingwei Zhao*, Shifa Zhu*, Difluorocarbene-MediatedTrimethylsilylation of Nucleophiles with HCF2N(TMS)2 asSilylation Reagent, Org. Lett. 2025, 27, 1741-1749. DOI: 10.1021/acs.orglett.5c00227.


135.  Chenguang Li, Tongxiang Cao*, Shifa Zhu*, Lewis Acid-Catalyzed Divergent Synthesis of Polysubstituted Furans and Pyrroles, Org. Chem. Front. 2025, 12, 2173. DOI: 10.1039/d4qo02216e.



134. Rui Wu, Zurong Xu, Dong Zhu, Shifa Zhu*, Dirhodium-Catalyzed Asymmetric Transformations of Alkynes via Carbene Intermediates, Acc. Chem. Res. 2025, 58, 799-811.  DOI: 10.1021/acs.accounts.4c00715.



133.  Chuntao Wang, Xianyang Long, Tongxiang Cao*, and Shifa Zhu*, Lantern-like Diplatinum(III)-CatalyzedRedox-free Borylation or Silylation of Alkynes, Chin. J. Chem. 2025, 43, 1015-1020. DOI: 10.1002/cjoc.202400896.


132. Zurong Xu, Dong Zhu, Rui Wu*,  and Shifa Zhu*, Tandem Rh(II)-catalyzed 1,3-acyloxy migration/intermolecular [2+2] cycloaddition of electronically deficient propargylic esters with alkenes and alkynes, Chem. Sci. 2025, 16, 205-210. DOI: 10.1039/D4SC06458E.



131. Xiang Gao, Wendeng Li, Yang Chen, Rui Wu*, Shifa Zhu*, Dirhodium-Catalyzed [2+2+2] Cycloaddition of 1,6-Diynes and Alkynes, J. Org. Chem. 2024, 89, 17248-17259.  DOI: 10.1021/acs.joc.4c01780 (Highlighted by Organic Chemistry Portal: http://www.organic-chemistry.org/abstracts/lit9/895.shtm)



130. Yang Chen and Shifa Zhu*, Recent advances in metal carbene-induced semipinacol rearrangements, Chem. Commun. 2024, 60, 11253-11266. (Invited Review)



129. Zurong Xu, Jiajun Lu, Huanfeng Jiang, Rui Wu* and Shifa Zhu*, Dirhodium(II)-catalyzed regio- and stereoselective cycloisomerization towards 6,5,3-tricyclic skeletons containing vicinal all-carbon quaternary stereocenters, Org. Chem. Front. 2024, 11, 5151-5159. DOI: 10.1039/D4QO00998C.



128. Wendeng Li, Rui Wu, Hao Ruan, Bo Xiao, Xiang Gao, Huanfeng Jiang, Kai Chen, Tian-Yu Sun*, and Shifa Zhu*, Axial Ligand Enables Synthesis of Allenylsilane through Dirhodium(II) Catalysis, Angew. Chem. Int. Ed. 2024, 63, e202409332. DOI:10.1002/anie.202409332. (Highlighted by Synfacts 2024, 20, 1060; DOI: 10.1055/s-0043-1775337).


127. 李康葵,龙先扬,黄岳,祝诗发*,可见光介导炔烃的自由基1,2-官能团化反应新进展,《化学学报》,2024,82, 658-676. DOI: 10.6023/A24030090.


126. Jiajun Lu, Zhehui Liao, Tongxiang Cao*, Shifa Zhu*, Synergistic Brønsted/Lewis acid catalyzed atroposelective synthesis of aryl-β-naphthol,Chin. Chem. Lett. 2025, 36, 109842. DOI: 10.1016/j.cclet.2024.109842. 


125. Jiamin He, Tongxiang Cao*, Kai Chen, Shifa Zhu*, LeveragingNonstrainedC−C  Bondsfor SelectiveCarboacylationofan UnactivatedAlkynevia TransientDearomatization, Org. Lett. 2024, 26, 2596-2600. DOI: 10.1021/acs.orglett.4c00608.  




123. Chuntao Wang, Dong Zhu, Rui Wu* and Shifa Zhu*, Dirhodium-catalyzed enantioselective synthesis of difluoromethylated cyclopropanes via enyne cycloisomerization, Adv. Sci. 2023, 2306404. DOI: 10.1002/advs.202306404.


122. Bo Yang, Kangkui Li, Yongdong Wang & Shifa Zhu*, Bifunctional two-carbon reagent: Made from acetylene via 1,2-difunctionalization and its applications, Sci. China Chem. 2024, 66, 936-944. DOI: 10.1007/s11426-023-1871-y. 


121. Kangkui Li, Jiazhen Deng, Xianyang Long and Shifa Zhu*, Photoinduced synthesis of C2-linked phosphine oxides via radical difunctionalization of acetylene, Green Chem. 2023, 25, 7253-7258. DOI: 10.1039/D3GC02794E. 


120. Dong Zhu, Shifa Zhu*, Heterocycles from Donor and Donor/Donor Carbenes. In: Topics in Heterocyclic Chemistry. Springer, Berlin, Heidelberg. DOI: 10.1007/7081_2023_64


119. Chuntao Wang, Rui Wu, Kai Chen*, Shifa Zhu*, Enantioselective Synthesis of Biscyclopropanes Using Alkynes as Dicarbene Equivalents, Angew. Chem. Int. Ed. 2023, 62, e202305864. DOI: 10.1002/anie.202305864.


118. Boxiang Liu, Zhicong Lin, Tairan Cheng, Tongxiang Cao, Shifa Zhu*, Synthesis of E-Dienyl Esters Using Acetylene as C2 Synthon, Org. Lett. 2023, 25, 3573-3577. DOI: 10.1021/acs.orglett.3c01209.


117. Rui Wu, Dong Zhu, Shifa Zhu*, Dirhodium:  Carbene Transformations and Beyond, Org. Chem. Front., 2023, 10, 2849-2878. DOI: 10.1039/D3QO00400G. (Invited Review)


116. Shiwei Lv, Zipeng Wang, Xiang Gao, Kai Chen*, Shifa Zhu*,  1,2-Difunctionalization of Acetylene Enabled by Light, Angew. Chem. Int. Ed. 2023, 62, e202300268. DOI: 10.1002/anie.202300268. 


115. Kangkui Li, Xianyang Long, Shifa Zhu*, Photoredox/Nickel Dual Catalysis-Enabled Modular Synthesis of Arylallyl Alcohols with Acetylene as the Two-Carbon Synthon, ACS Catal. 2023, 13, 2422-2431. DOI: 10.1021/acscatal.2c06178.


114. Zhicong Lin, Boxiang Liu, Yu Wang, Siju Li and Shifa Zhu*, Synthesis of Vinyl-Substituted Alcohols Using Acetylene as C2 Building Block, Chem. Sci., 2023, 14, 1912-1918 (Highlighted by ChemistryViews News). DOI: 10.1039/D2SC06400F 


113. Boxiang Liu, Zhicong Lin, Yu Wang, Tairan Cheng, Tongxiang Cao, Shifa Zhu*, Trimerization of Acetylene and Alkene: Rapid Access to Polyenes, CCS Chem., 2023, 5, 1077-1085. DOI: 10.31635/ccschem.022.202202579.



112. Zhuwen Wei, Yang Chen, Jianghui Wang, Tao Yang, Zujin Zhao* and Shifa Zhu*, De Novo Synthesis of α-Oligo(arylfuran)s and Its Application in OLED as Hole-Transporting Material, Chem. Eur. J. 2023, e202203444 (VIP, 入选Editors' Choice:Spotlights). DOI: 10.1002/chem.202203444. 


111. Zipeng Wang, Tongxiang Cao*, Shifa Zhu*, Gold-catalyzed enynal and enynol coupling by selectively steering two transient vinyl-gold intermediates, Org. Lett. 2023, 25, 9296-9300. DOI: 10.1021/acs,orglett.2c03890 .


110. Rui Wu, Yang Chen, Shifa Zhu*, Rh(II)-Catalyzed Enynal Cycloisomerization for Generation of Vinyl Carbene: Divergent Access to Polycyclic Heterocycles, ACS Catal. 2023, 13, 132-134. DOI: 10.1021/acscatal.2c04832 


109. Qiu Shi, Yang Chen, Tongxiang Cao*, Shifa Zhu*, Construction of [2,5]-Furanophanes by Carbene-Mediated Alkynyl Migration Cyclization, Org. Lett. 2022, 24, 8142-8146. DOI: 10.1021/acs.orglett.2c03185. 


108. Wendeng Li, He Zhang, Kai Chen, Huanfeng Jiang, Jianwei Sun and Shifa Zhu*, Palladium-Catalyzed Intramolecular Enantioselective C(sp3)-H Insertion of Donor/Donor Carbenes, Chem. Sci. 2022, 13, 12396-12402. DOI: 10.1039/D2SC03524C  


107. Yang Chen, Shifa Zhu*, Modular Construction of a-Furanyl Ketones via Semi-pinacol Rearrangement-Mediated Ring Expansion, Org. Chem. Front.2022, 9, 6194-6199. DOI: 10.1039/D2QO01324J.


106. Rongyu Zhang, Meng Wu, Tongxiang Cao, Kui Luo, Fangjiao Huang, Ruoying Zhang, Zhipeng Huang, Jinming Zhou*, Yongdong Wang*, Shifa Zhu*, Identification of the gossypol derivatives as andhydrogen receptor inhibitor, Bioorg. Med. Chem. Lett.2022, 75, 128952. DOI: 10.1016/j.bmcl.2022.128952. 


105. Shiwei Lü, Zipeng Wang and Shifa Zhu*, Thiol-Yne Click Chemistry of Acetylene-Enabled Macrocyclization, Nat. Commun.2022, 13, 5001. DOI: 10.1038/s41467-022-32723-0.


104. Qiu Shi, Zhehui Liao, Zhili Liu, Jiajia Wen, Chenguang Li, Jiamin He, Jiazhen Deng, Shan Cen, Tongxiang Cao*,  Jinming Zhou*, Shifa Zhu*, Dearomative Rearrangement: Divergent Synthesis of Benzazepines and Bridged Polycycloalkanones, Nat. Commun.2022, 13, 4402. DOI: 10.1038/s41467-22-31920-1.




103. Tairan Cheng, Boxiang Liu, Rui Wu and Shifa Zhu*, Cu-Catalyzed Carboboration of Acetylene with Michael Acceptors, Chem. Sci. 2022, 13,  7604-7609. DOI: 10.1039/D2SC02306G.



102. Qinglin Yao, Boxiang Liu, Tongxiang Cao and Shifa Zhu*, Migratory Insertion of Copper-Allenylidene from Propargyl Ester, Chem. Commun.202258, 4969-4972. DOI: 10.1039/D2CC00681B 
(Chemical Communications HOT Articles 2022 and 2022 Pioneering Investigators) 



101. Bo Yang, Shaodong Lu, Yongdong Wang and Shifa Zhu*, Diverse Synthesis of C2-Linked Functionalized Molecules via Molecular Glue Strategy with Acetylene, Nat. Commun., 2022, 13, 1858. DOI: 10.1038/s41467-022-29556-2.


100. Dong Zhu, Tongxiang Cao, Kai Chen* and Shifa Zhu*, Rh2(II)-Catalyzed Enantioselective Intramolecular Büchner Reaction and Aromatic Substitution of Donor-Donor Carbenes, Chem. Sci., 2022, 13, 1992-2000. DOI: 10.1039/D1SC05374D.


99. Yanmei Chen, Zhehui Liao, Tongxiang Cao* and Shifa Zhu*, An Efficient Method to Synthesize N/O, O-difluoroboron Complexes from Alkynes, Green Synth. Catal., 2022, 3, 89-94. DOI: 10.1016/j.gresc.2021.11.001.

98. Yang Chen, Pingchuan Shen, Tongxiang Cao, Hao Chen, Zujin Zhao* and Shifa Zhu*, Bottom-up Modular Synthesis of Well-Defined Oligo(arylfuran)s, Nat. Commun., 2021, 12, 6165. DOI: 10.1038/s41467-021-26387-5.

97. Shaotong Qiu, Xiang Gao and Shifa Zhu*, Dirhodium(II)-Catalysed Cycloisomerization of Azaenyne: Rapid Assembly of Centrally and Axially Chiral Isoindazole Frameworks, Chemical Science, 2021, 12, 13730-13736.
DOI: 10.1039/D1SC04961E. (2021 Chemical Science HOT Article Collection)

96. Hejiang Luo, Tongxiang Cao*, Shifa Zhu*,  Divergent Synthesis of Ketone-Fused Indoles/Pyrroles via Metal-Guided Friedel-Crafts Cyclization, Chin. J. Org. Chem., 2021, 41, 3521. DOI: 10.6023oc202105021.

95. Bo Yang, Shi-Jun Li, Yongdong Wang*, Yu Lan*, Shifa Zhu*, Hydrogen radical-shuttle (HRS)-enabled photoredox synthesis of indanones via decarboxylative annulation. Nat. Commun., 2021, 12, 5257. DOI: 10.1038/s41467-021-25594-4.

94. Rui Wu, Jiajun Lu, Tongxiang Cao, Jun Ma, Kai Chen*, Shifa Zhu*, Enantioselective Rh(II)-Catalyzed Desymmetric Cycloisomerization of Diynes: Constructing Furan-Fused Dihydropiperidines with an Alkyne-Substituted Aza-Quaternary Stereocenter, J. Am. Chem. Soc., 2021, 143, 14916. DOI: 10.1021/jacs.1c07556.


93. Yi Kong, Tongxiang Cao* and Shifa Zhu*, TEMPO-Regulated Regio- and Stereoselective Cross-Dihalogenation with Dual Electrophilic X+ Reagents,  Chin. J. Chem., 2021, 39, 3004. DOI: 10.1002/cjoc.202100472.

92. Shaotong Qiu, Tongxiang Cao* and Shifa Zhu*, Catalyst-Free Synthesis of Isoxazolidine from Nitrosoarene and Haloalkyne via 1,2-Halo-Migration/[3+2] Cycloaddition Cascade, Org. Biomol. Chem., 2021, 19, 3139. DOI:10.1039/d1ob00421b.

91. Zhehui Liao, Jiantao Zhang, Tongxiang Cao* and Shifa  Zhu*, Copper Catalyzed  Asymmetric  Synthesis  of  Bicyclo[3.n.1]alkenones, J. Org. Chem., 2021, 86, 5388. DOI: 10.1021/acs.joc.1c00146.

90. Tongxiang Cao, Qiu Shi and Shifa Zhu*, Benzene-Free Synthesis of Multisubstituted Catechol via Oxidative Dearomatic Reorganization, Org. Lett., 2021, 23, 1411. DOI: 10.1021/acs.orglett.1c00071.

89. Zhili Liu, Lianfen Chen, Dong Zhu, and Shifa Zhu*, Formal Allylation and Enantioselective Cyclopropanation of Donor/Acceptor Rhodium(II) Azavinyl Carbenes, Org. Lett., 2021, 23, 1275. DOI: 10.1021/acs.orglett.0c04251.

88. Feng Wu, Tairan Cheng, and Shifa Zhu*, Construction of Partially Protected Nonsymmetrical Biaryldiols via Semipinacol Rearrangement of o-NQM Derived from Enynones, Org. Lett., 2021,  23, 71. DOI: 10.1021/acs.orglett.0c03717

87. Feng Wu, Shiwei Lu, and Shifa Zhu*, Regioselectivity-Switchable Intramolecular Hydroarylation of Ynone, Adv. Synth. Catal., 2020,  362, 5632. DOI:10.1002/adsc.202001152.

86. Feng Wu, Li Zhang and Shifa Zhu*, 1,4-Addition of o-naphthoquinone methides induced by silver-catalyzed cyclization of enynones: an  approach to unsymmetrical triarylmethanes and benzo[f]chromenes, Org. Chem. Front., 2020, 7,  3387,  DOI: 10.1039/d0qo00825g.

85. Ling Zhang, Qiu Shi, Tongxiang Cao* and Shifa Zhu*, Catalytic Regio- and Stereoselective Intermolecular [5+2] Cycloaddition via Conjugative Activation of Oxidopyrylium, Chem. Commun., 2020, 56, 9533, DOI: 10.1039/D0CC04309E.

84. Rui Wu#, Kai Chen#, Jun Ma#, Zhi-Xiang Yu* & Shifa Zhu*, Synergy of Activating Substrate and Introducing C-H···O Interaction to Achieve Rh2(II)-Catalyzed Asymmetric Cycloisomerization of 1,n-Enynes, Sci. China Chem., 2020, 63, 1230. DOI: 10.1007/s11426-020-9794-3.

(#These authors contributed equally to this work)

83. Hejiang Luo, Chuan He, Huanfeng Jiang, and Shifa Zhu*, Rapid Access to Oxabicyclo[2.2.2]octane Skeleton through Cu(I)-Catalyzed Generation and Trapping of Vinyl-o-Quinodimethanes (Vinyl-o-QDMs), Chin. J. Chem., 2020, 38, 1052. DOI: 10.1002/cjoc.202000144.


82. Feng Wu, Shifa Zhu, Benzopyrylium Salts, Science of Synthesis Knowledge Updates, 2020, 1, 159; DOI: 10.1055/sos-SD-114-00178.

81. Ling Zhang#, Tongxiang Cao#, Huangfeng Jiang ang Shifa Zhu* Deconstructive Reorganization: De Novo Synthesis of Hydroxylated Benzofuran. Angew. Chem., Int. Ed., 2020, 59, 4670. DOI: 10.1002/anie.201915212.

(#These authors contributed equally to this work)


80. Dong Zhu, Lianfen Chen, Hanlin Fan, Qinglin Yao and Shifa Zhu* Recent Progress on Donor and Donor-Donor Carbenes. Chem. Soc. Rev., 2020, 49, 908. DOI: 10.1039/C9CS00542K.


79. Jiantao Zhang, Zhehui Liao, Lianfen Chen, Huanfeng Jiang, Shifa Zhu*, Construction  of Polycyclic Bridged Indene Derivatives by a Tandem 1,  3-Rearrangement/intramolecular Friedel-Crafts Cyclization of Propargyl  Acetates, Chem. Commun., 2019, 55, 7382. DOI: 10.1039/c9cc03715b.


78.Jiantao, Zhang, Zhehui Liao, Lianfen Chen, Shifa Zhu*, Rapid Acess to Oxa-Bridged Bicylic Skeletons through Gold-Catalyzed Tendem Rearrangement Reaction, Chem, Eur. J., 2019, 25, 9405. DOI:10.1002/chem.201900807.(Hot paper , invited for OMCOS-20)

77. Shaotong Qiu, Renxiao Liang, Yongdong Wang, Shifa Zhu* Domino Reaction between Nitrosoarenes and Ynenones for Catalyst-Free Preparation of Indanone-Fused Tetrahydroisoxazoles, Org. Lett., 2019, 21, 2126. DOI:10.1021/acs.orglett.9b00426.

76. He Zhang, Tongxiang Cao, Hejiang Luo, Lianfen Chen, Shifa Zhu*, Enynone-Enabled Migratory Insertion and Schmittel Cyclization Cascade for the Synthesis of Furan-Fused Fluorenes, Org, Chem, Front., 2019, 6, 1118.  DOI: 10.1039/c9qo00045c.

75.Feng Wu, Shifa Zhu*  A Strategy  to Obtain o-Naphthoquinone  Methides: Ag(I) - Catalyzed Cyclization of Enynones for the Synthesis  of Benzo[h] chromanes and Naphthopyryliums, Org. Lett., 2019, 21, 1488. DOI: 10.1021/acs.orglett.9b00281.

74. Feng Wu, Lianfen Chen,* Yongdong Wang, Shifa,Zhu*, Gold-Catalyzed Generation of Azafulvenium from Enyne Sulfonamide: Rapid Access to Full-Substituted Pyrroles, Org. Chem. Front., 2019,  6, 480. DOI: 10.1039/C8QO01278D

73. Tongxiao Cao, Lianfen Chen, Shifa Zhu* Mechanism-Guided Scaffold Diversification: Perturbing and Trapping the Intermediates of Maltol-Type Cascade Claisen Rearrangement, Org. Lett., 2019, 21, 90. DOI: 10.1021/acs.orglett.8b03519


72.Lianfen Chen, Zhili Liu, Shifa Zhu* Donor- and acceptor-enyanls/enynones, Org. Biomol. Chem., 2018, 16, 8884. DOI: 10.1039/C8OB02348D (Invited)

71. Dong Zhu, Liangfen Chen, He Zhang, Zhiqiang Ma, Huangfeng Jiang, Shifa Zhu* Catalyst-Controlled Highly Chemo- and Stereoselective Allylic C-H Insertion and Cyclopropanation of Donor/Donor-Carbenes, Angew.Chem., Int. Ed.,  2018, 57, 12405. DOI: 10.1002/anie.201805676.

70. Changyuan Zhang, Lianfen Chen, Kai Chen, Chuntao Wang, Zurong Xu, Huangfeng Jiang, Shifa Zhu* Cu(I)-Catalyzed Stereoselective Synthesis of Trisubstituted Z-enol Esters via Interrupting the 1,3-O-transposition Reaction, Org. Chem. Front., 2018, 5, 2510. DOI:10.1039/c8qo00664d

69. Tongxiang Cao, Yi Kong, Kui Luo, Lianfen Chen, and Shifa Zhu*, Cascade Claisen Rearrangement: Rapid Synthesis of Polysubstituted Salicylaldehydes and Total Synthesis of Hemigossypol and Gossypol, Angew. Chem., Int. Ed., 2018, 57, 8702. DOI: 10.1002/anie.201801612.



68. Lianfen Chen, Kai Chen, Shifa Zhu*, Transition-Metal-Catalyzed Intramolecular Nucleophilic Addition of Carbonyl Groups to Alkynes, Chem, 2018, 4, 1208. DOI: 10.1016/j.chempr.2018.02.001.



67.  Jiantao Zhang, Lianfen Chen, Huanfeng Jiang and Shifa Zhu*, Catalytic [1,3] O-to-C Rearrangement: Rapid Access to Bridged Bicyclic System,  Chem. Eur. J., 2018, 24, 6927. DOI: 10.1002/chem.201801062. (Hot papper)


66. Hejiang Luo, Renxiao Liang, Lianfen Chen*, Huanfeng Jiang and Shifa Zhu*, A silver-catalyzed three-component reaction via stabilized cation: synthesis of polysubstituted tetrahydronaphthols and tetrahydronaphthylamines, Org. Chem. Front., 2018, 5, 1160. DOI: 10.1039/C7QO01122A

65. Kui Luo, Ling Zhang, Huanfeng Jiang, Lianfen Chen* and Shifa Zhu*, Selectivity-switchable construction of benzo-fused polycyclic compounds through a gold-catalyzed reaction of enyne-lactone, Chem. Commun., 2018, 54, 1893. DOI: 10.1039/C7CC09786G.

64. Changyuan Zhang, Lianfen Chen, Kai Chen, Huanfeng Jiangand Shifa Zhu*, Iron/zinc-catalyzed benzannulation reactions of 2-(2-oxo-alkyl)benzketones leading to naphthalene and isoquinoline derivatives, Org. Chem. Front., 2018, 5, 1028. DOI: 10.1039/C7QO01152K.(Hot papper)

63. Renxiao Liang, Jiantao Zhang, Lianfen Chen*, and Shifa Zhu*Efficient Assembly of Tetracyclic Framework of Fluorenols through Silver-Catalyzed Tandem Reaction of Acceptor-Enynals and Alkynes via Unfavorable 6-endo-dig Cyclization, Asian J. Org. Chem., 2018, 7, 545.  DOI: 10.1002/ajoc.201700613


62. Kui Luo, Tongxiang Cao, Huanfeng Jiang, Lianfen Chen,* and Shifa Zhu*, Gold-Catalyzed Ring Expansion of Enyne-Lactone: Generation and Transformation of 2‑Oxoninonium, Org. Lett., 2017, 19, 5856. DOI: 10.1021/acs.orglett.7b02834.


61. Shaotong Qiu, Lianfen Chen, Huanfeng Jiang, and Shifa Zhu*, CuCl/Et3N-Catalyzed Synthesis of Indanone-fused 2-Methylene Pyrrolidines from Enynals and Propargylamines, Org. Lett., 201719,  4540. DOI:  10.1021/acs.orglett.7b02121.


60. Jiantao Zhang, Kai Chen, Huanfeng Jiang, and Shifa Zhu*, Cascade One-Pot Synthesis of Indanone-Fused Cyclopentanes from the Reaction of Donor-Acceptor Cyclopropanes and Enynals via a Sequential Hydrolysis/Knoevenagel Condensation/[3+2] Cycloaddition, Adv. Synth. Catal., 2017359, 2924. DOI 10.1002/adsc.201700345.



59. Min Zheng, Kai Chen, Shifa Zhu*, One-pot Synthesis of Indole Derivatives from the Reaction of Nitroalkynes and Alkynes through Hg-Carbene Intermediate, Synthesis, 2017, 49, 4173.  DOI: 10.1055/s-0036-1588416. (Invited Contribution)


58. Changyuan Zhang, Huanfeng Jiang, Shifa Zhu*, Gold-catalyzed ring-expansion  through acyl migration to afford furan-fused polycyclic compounds, Chem.  Commun., 2017, 53, 2677. DOI: 10.1039/c7cc00218a.

57. Kai Chen, Shifa Zhu*, NHC–AuCl/Selectfluor: An Efficient Catalytic System  for π-Bond Activation, Synlett., 2017, 28, 640. DOI: 10.1055/s-0036-1588693. (Invited Account)


56. Tongxiang Cao, Kai Chen, Shifa Zhu*, An efficient Approach to Generate Aryl  Carbene: Gold-Catalyzed Sequential Activation of 1,6-Diynes. Org. Chem.  Front., 2017, 4, 450. DOI: 10.1039/C6QO00769D.


55. Yuefeng Zhou, Jun Ma, Kai Chen, Huanfeng Jiang, Shifa Zhu*,  Selectivitiy-Switchable Oxidation of Tetraarylenthylenes to Fused Polycyclic  Comounds, Chem. Commun., 2016, 52, 13345. DOI: 10.1039/C6CC08155J.



54. Hejiagn Luo, Kai Chen, Huanfeng Jiang, Shifa Zhu*, A Route to  Polysubstituted Aziridines from Carbene and Imines through a Nondiazo Approach,  Org. Lett., 2016, 18, 5208. DOI: 10.1021/acs.orglett.6b02429.



53. Kai Chen#, Feng Wu#, Lijuan Ye, Ziyou Tian, Zhi-Xiang  Yu*, Shifa Zhu*, Cycloaddition Reaction of Vinylphenylfurans and Dimethyl  Acetylenedicarboxylate to [8+2] Isomers via Tandem [4+2]/Diradical Alkene-Alkene  Coupling/[1,3]-H Shift Reactions: Experimental Exploration and DFT Understanding  of Reaction Mechanism, J. Org. Chem., 2016, 81,  8155. DOI: 10.1021/acs.joc.6b00792.


52. Min Zheng, Feng Wu, Kai Chen*, Shifa Zhu*, Styrene as 4π-Component in  Zn(II)-Catalyzed Intermolecular Diels-Alder/Ene-Tandem Reaction, Org.  Lett., 2016, 18, 3554. DOI: 10.1021/acs.orglett.6b01511.

51. Jiantao Zhang, Yelin Xiao, Kai Chen*, Wanqing Wu, Huanfeng Jiang, and Shifa  Zhu*, Zinc-Catalyzed Tandem Diels-Alder Reactions of Enynals with Alkenes:  Generations of Cyclic o-Quinodimethanes (o-QDMs), Adv. Synth. Catal., 2016, 358, 2684. DOI: 10.1002/adsc.201600266.



50. Dong Zhu, Jun Ma, Kui Luo, Hongguang Fu, Li Zhang*, Shifa Zhu*,  Enantioselective Intramolecular C-H insertion of Donor- and Donor/Donor-Carbenes  via a Non-Diazo Approach, Angew. Chem. Int. Ed., 2016, 55,  8452. DOI: 10.1002/anie.201604211. (Most Accessed 06/2016)



49. Jun Ma, Kai Chen, Hongguang Fu, Li Zhang, Wanqing Wu, Huanfeng Jiang, Shifa  Zhu*, Dual Catalysis: Proton/ Metal-Catalyzed Tandem Benzofuran  Annulation/Carbene Transfer Reaction. Org. Lett., 2016, 18,  1322. DOI: 10.1021/acs.orglett.6b00260.


48. Renxiao Liang, Kai Chen, Qiaohui Zhang, Jiantao Zhang, Huanfeng Jiang, Shifa  Zhu*, Rapid Access to 2-Methy lene Tetrahydrofurans and γ-Lactones: A Four-Step  Tandem Process, Angew. Chem. Int. Ed., 201655, 2587. DOI: 10.1002/anie.201511133.


47. Shifa Zhu*, Qiaohui Zhang, Kai Chen, Huanfeng Jiang, Synergistic Catalysis:  Metal/Proton-Catalyzed Cyclization of Alkynones Toward  Bicyclo[3.n.1]alkanones, Angew. Chem. Int. Ed., 2015, 54, 9414. DOI: 10.1002/anie.201504964.(Most Accessed 07/2015)


46. Jun Ma, Li Zhang, Shifa Zhu*, Enynal/Enynone: A Safe and Practical  Carbenoid, Curr. Org. Chem., 2016, 20, 102. DOI: 10.2174/1385272819666150608222517.



45. Renxiao liang, Huanfeng Jiang, Shifa Zhu*, An Efficient Route to Highly  Strained Cyclobutenes: Indium-Catalyzed Reactions of Enynals with Alynes,  Chem. Commun., 2015, 51, 5530. DOI: 10.1039/C4CC08506J.(Featured in ChemComm  2015 Emerging Investigators Issue)


44. Shifa Zhu*, Xiaobing Huang, Tianqi Zhao, Tongmei Ma, Huanfeng Jiang,  Metal-Catalyzed Formation of 1,3-Cyclohexadienes: A Catalyst-Dependent Reaction,  Org. Biomol. Chem., 2015, 13, 1225. DOI: 10.1039/C4OB01922A.


43. Jun Ma, Huanfeng Jiang, Shifa Zhu*, NHC-AuCl/Selectfluor: A Highly Efficient  Catalytic System for Carbene Transfer Reactions, Org. Lett., 2014,  16, 4472. DOI: 10.1021/ol502018d.


42. Renxiao Liang, Tongmei Ma, Shifa Zhu*,Silver-Catalyzed Reaction of Enynals  with Alkenes: A Tandem 1,3-Dipolar Cycloaddition/Cyclopropanation, Org.  Lett., 2014, 16, 4412. DOI: 10.1021/ol5017299.


41. Shifa Zhu*, Hua Huang, Zhicai Zhang, Tongmei Ma*, Huanfeng Jiang,  Mechanistic Insight into Transition Metal-Catalyzed Reaction of Enynal/Enynone  with Alkenes: Metal-Dependent Reaction Pathway, J. Org. Chem., 2014,79, 6113. DOI: 10.1021/jo500838x.


40. Ruoshan Zheng, Shifa Zhu*, The Application of o-Quinodimethanes In Organic  Synthesis, Chin. J. Org. Chem., 2014, 37, 1322. DOI: 10.6023/cjoc201401006. (Review) 



39. Shifa Zhu*, Lang Hu, Huanfeng Jiang, Gold-Catalyzed Tandem Diels-Alder  Reactions of Enynals/ Enynones with Alkenes: Generation and Trapping of Cyclic  o-QDMs, Org. Biomol. Chem., 2014, 12, 4104. DOI: 10.1039/C4OB00321G (封面文章) , (Included by ChemInform., 2014, 45, DOI: 10.1002/chin.201447058)


38. Shifa Zhu*, Chao Wang, S. Zhao, Y. Xiao, L. Hu, Z. Huang, Modular Approach  to the Synthesis of Polydentate NHC-Ligand Precusors (Benzimidazolium Salts)  Containing Axial 1,1'-Binaphthyl via Pd-Catalyzed N-Aryation of  1,2-Diaminobenzene, Synthesis, 2014, 46, 212. DOI: 10.1055/s-0033-1340286.


37. Shifa Zhu*, Zhengjiang Guo, Zhipeng Huang, Huanfeng Jiang, Bioinspired  Intramolecular Diels-Alder Reaction: A Rapid Access to Highly-Strained  Cyclopropane-Fused Polycyclic Skeleton, Chem. Eur. J., 2014, 20, 2425. DOI: 10.1002/chem.201304839. (封面文章) 


36. Shifa Zhu*, Lijuan Ye, Wanqing Wu, Huanfeng Jiang, N-Heterocyclic  carbene-gold(I)-catalyzed carbohetero- functionalization of alkenes with  arylboronic acids, Tetrahedron, 2013, 69, 10375. DOI: 10.1016/j.tet.2013.09.097


35. Shifa Zhu*, Zhicai Zhang, Xiaobing Huang, Huanfeng Jiang*, Zhengjiang Guo,  Gold-Catalyzed Reaction of Enynals/Enynones with Norbornenes: Generation and  Trapping of Cyclic o-QDM, Chem. Eur. J., 2013, 19, 4695. DOI: 10.1002/chem.201300232.

34. Shifa Zhu*, Yelin Xiao, Zhengjiang Guo, Huanfeng Jiang. Iron-Catalyzed  Benzannulation Reactions of 2-Alkylbenzaldehydes and Alkynes Leading to  Naphthalene Derivatives, Org. Lett., 2013, 15,  898. DOI: 10.1021/ol4000394 (Highlighted by SYNFACTS, 2013, 9, 501; Included by ChemInform., 2013, 44, DOI: 10.1002/chin.201328093)

33. Shifa Zhu*, Renxiao Liang, Huanfeng Jiang, Wanqing Wu, An Efficient Route to  Polysubstituted Tetrahydronaphthols: Silver-Catalyzed [4+2] Cyclization of  2-Alkylbenzaldehydes and Alkenes, Angew. Chem. Int. Ed., 2012,  51, 10861. DOI: 10.1002/anie.201204798 (Highlighted by Chin. J. Org. Chem., 2012, 32, 2395;  Included by ChemInform., 2013, 44, DOI: 10.1002/chin.201312082)

32. Shifa Zhu*, Renxiao Liang, Huanfeng Jiang, A direct and practical approach  for the synthesis of N-heterocyclic carbene coinage metal complexes,  Tetrahedron, 2012, 68, 7949. DOI: 10.1016/j.tet.2012.07.009.

31. Shifa Zhu*, Renxiao Liang, Lijuan Chen, Chao Wang, Yanwei Ren, Huanfeng  Jiang, A direct and practical approach for the synthesis of Au(I)-NHC complexes  from commercially available imidazololium salts and Au(III) salts,  Tetrahedron Letters, 2012, 53,  815. DOI: 10.1055/s-0033-1340286. (被《有机合成试剂百科全书》收录:e-EROS, 2014, DOI: 10.1002/047084289X.rn01733,  http://onlinelibrary.wiley.com/doi/10.1002/047084289X.rn01733/abstract)

30. Shifa Zhu*, Chao Wang, Lijuan Chen, Renxiao Liang, Yinfeng Yu, Huanfeng   Jiang. Modular Approach for Synthesis of Vicinal Diamines Containing  Axial  Chiral 1,1'-Binaphthyl from 1,2-Diaminoethane by Pd-Catalyzed  N-Arylation  Reactions, Org. Lett., 2011, 13, 1146.  DOI: 10.1021/ol103169z.

29. Shifa Zhu*, Lijuan Chen, Renxiao Liang, Chao Wang, Xiujun Wang, Yanwei  Ren,  Huanfeng Jiang. A practical system to synthesize the  multiple-substituted  2,5-dihydrofuran by the intermolecular dipolar  cycloaddition reactions involving  acceptor/acceptor substituted diazo  reagents. Tetrahedron, 2011,  67, 5507. DOI: 10.1016/j.tet.2011.05.028. (Included by ChemInform., 2011, 42, DOI:  10.1002/chin.201148100)

28. Xue Xu, Shifa Zhu, Xin Cui, Lukasz Wojtas, X. Peter Zhang*,   Cobalt(II)-Catalyzed Asymmetric Olefin Cyclopropanation with   alpha-Ketodiazoacetates, Angew. Chem. Int. Ed., 2013, 52, 11857.

27. Shifa Zhu, Xin Cui, Peter Zhang, Ligand Effect on Cobalt(II)-Catalyzed  Asymmetric Cyclopropan- ation with Diazosulfones: Approaching High  Stereoselectivity through Modular Design of D2-Symmetric Chiral Porphyrins,  Eur. J. Inorg. Chem., 2012, 430.(microreview


26. Shifa Zhu, Xue Xu, Jason Perman, Peter X. Zhang*. A General and Efficient  Cobalt(II)-Based Catalytic System for Highly Stereoselective Cyclopropanation of  Alkenes with alfa-Cyanodiazoacetates, J. Am. Chem. Soc., 2010,  132, 12796.


25. Shifa Zhu, Joshua V. Ruppel, Hongjian Lu, Lukasz Wojtas, Peter X. Zhang*.  Cobalt-Catalyzed Asymmetric Cyclopropanation with Diazosulfones: Rigidification  and Polarization of Ligand Chiral Environment via Hydrogen Bonding and  Cyclization. J. Am. Chem. Soc., 2008, 130, 5042.  (Highlighted by SYNFACTS, 2008, 7, 720. and Angew. Chem. Int. Ed., 2009, 48,  850.) 


24. Shifa Zhu, Jason Perman, X. Peter Zhang*. Acceptor/Acceptor-Substituted Diazo Reagents for Carbene Transfers: Cobalt-Catalyzed Asymmetric Z-Cyclopropanation of Alkenes with α-Nitro-Diazo- acetates. Angew. Chem., Int. Ed., 2008, 47, 8460. (Highlighted by SYNFACTS2009, 1, 74. and Angew. Chem. Int. Ed., 2009, 48, 850.)


23. Xin Cui, Xue Xu, Hongjian Lu, Shifa Zhu, Lukasz Wojtas, and X. Peter Zhang*, Enantioselective Cyclopropenation of Alkynes with Acceptor/Acceptor-Substituted Diazo Reagents via Co(II)-Based Metalloradical Catalysis. J. Am. Chem. Soc., 2011, 133, 3304.



22. Shifa Zhu, Yuanxi Liao, Shizheng Zhu*. Transition-Metal-Catalyzed Formation of trans Alkenes via Coupling of aldehydes. Org. Lett., 2004, 6, 377.


21. Velusamy Subbarayan, Joshua V.Ruppel, Shifa Zhu, Jason A. Perman, X. Peter*. Zhang, Highly asymmetric cobalt-catalyzed aziridination of alkenes with trichloroethoxysulfonyl azide (TcesN3). Chem. Commun., 2009,  4266.


20. Shifa Zhu, Yuanxi Liao, Shizheng Zhu*. The First Example of Catalytic Aziridination Mediated by Arsonium Ylides: Preparation of trans Pentafluorophenyl-Containing Aziridines, Synlett., 2005, 1429.

19. Shizheng Zhu*, Shifa Zhu, Guifang Jin, and Zhanting Li*. Strong Phenyl- perfluorophenyl p-p Stacking Interactions and C-H…F-C Hydrogen Bonding Interactions in The Crystalline of Corresponding Aromatic aldimines. Tetrahedron Lett., 2005, 46, 2713.


18. Shifa Zhu, Chunhui Xing, Shizheng Zhu*. Stereoselective Preparation of Trifluoromethyl Containing 1,4-Oxathiolane derivatives through ring expansion reaction of 1,3-oxathiolanes, Tetrahedron, 2006, 62, 829.

17. Shizheng Zhu*, Shifa Zhu, Yuanxi Liao. Rhodium(II)-catalyzed addition of 2-diazo(fluoroalkyl) acetoacetates to sulfides: a simple synthesis of stable sulfonium ylides. Journal of Fluorine Chemistry, 2004, 125, 1071.

16. Shifa Zhu, Shizheng Zhu*, Yuanxi Liao, Chaofeng Huang, Zhanting Li*. Co-existing Intermolecular Halogen Bonding and Hydrogen Bonding in the Compound Trans-5,10-bis(1-bromodifluoroacetyl-1-ethoxycarbonyl-methylidene) Thianthrene. Chinese Journal of Chemistry, 2004, 22, 896.

15. Shifa Zhu, Chunhui Xing, Wan Pang, Shizheng Zhu*. Rh2(OAc)4-Catalyzed Formation of trans Alkenes From the Reaction of Aldehydes with Perfluorophenyl Diazomethane Through Tellurium Ylide. Tetrahedron Lett., 2006, 47, 5897.


14. Shifa Zhu, Wan Pang, Chunhui Xing, Shizheng Zhu, Lewis Base-Catalyzed Formation of α-Trifluoromethyl Alcohol from CF3SiMe3 and Carbonyl-Containing Compounds, Chinese Journal of Chemistry, 2007, 25, 233.

13. Ruixin Zhu, Shifa Zhu, Junhong Zhou, Minbo Chen*. The Atoms in Molecules (AIM) Analysis of Abnormal Bonding of Several Fluorinated Supramolecular Systems, Acta Chimica Sinica., 2006, 164, 191.



12. Wan Pang, Shifa Zhu, Huanfeng jiang and Shizheng Zhu*. Transition metal-catalyzed formation of CF3-substituted α,β-unsaturated alkene and the synthesis of α-trifluoromethyl substituted β-amino ester. Tetrahedron,2006, 62, 11760.

11. Chunhui Xing, Xianfu Li, Shifa Zhu, Shizheng Zhu*. Synthesis of (E)-α-Per(poly)fluoroalkanesulfonyl- α,β-unsaturated Ketones and their Hetero Diels-Alder Reactions with Vinyl Ether, Tetrahedron Lett., 2006, 47, 4951.

10. Hui wang, Shifa Zhu, Qinying Deng*, ShiZheng Zhu*. A facile synthesis of 4-gem-difluoromethylene β-lactamand its derivatives from BrCF2CF2Br, Journal of Fluorine Chemistry, 2006, 127, 1195.

9. Jun Li, Yongbin Han, Teresa B. Freedman, Shifa Zhu, Deborah J. Kerwood and Yan-Yeung Luk*, Utilizing the high dielectric constant of water: efficient synthesis of amino acid-derivatized cyclobuten- ones. Tetrahedron Lett., 2008, 49, 2128.

8. Wan Pang; Shifa Zhu; Huanfeng Jiang; Shizheng Zhu*. A novel synthesis of 5-perfluorophenyl 4,5-dihydro-1H-pyrazoles in THF or water. Journal of Fluorine Chemistry 2007, 128, 1379.

7. Wan Pang; Shifa Zhu; Huanfeng Jiang; Shizheng Zhu*. Rh(II)-catalyzed formation and rearrange- ment of trifluoroacetyl-containing sulfur ylides. Tetrahedron 2007, 63, 4543.

6. Wan Pang; Shifa Zhu; Chunhui Xing; Nianhua Luo; Huanfeng Jiang; Shizheng Zhu*. Synthesis of stable arsonium and sulfur ylides fromperfluoroalkanesulfonyl diazocarbonyl compoundsand their X-ray diffraction analysis, Journal of Fluorine Chemistry 2008, 129, 343.

5. Weibing Liu, Huanfeng Jiang*, Shifa Zhu, et al., Hydroalkylation leading to heterocyclic compounds (Part 2): practical synthesis of polysubstituted 1,2,3,4-tetrahydropyridines through multicomponent reactions (MCRs), Tetrahedron, 2009, 65, 7985.

4. Weibing Liu, Huanfeng Jiang*, Peng Zhou, Shifa Zhu DABCO-Induced [2+2+2] Cycloaddition Reaction of Ethyl Propiolate and Arylaldehydes to Synthesize 4-Aryl-4H-pyrans, Synlett.,2009, 20, 3295.

3. Hua Cao, Huanfeng Jiang*, Ronghuan Mai, Shifa Zhu, Chaorong Qi, Silver-Catalyzed One-Pot Cyclization Reaction of Electron- Deficient Alkynes and 2-Yn-1-ols: An Efficient Domino Process to Polysubstituted Furans Adv. Synth. Catal., 2010, 352, 143.

2. Wan Pang, Shifa Zhu, Yong Xin, Huanfeng Jiang, Shizheng Zhu,Rh2(OAc)4 catalyzed formation of fluorine-containing polysubstituted furans from diazocompounds and aromatic alkynes, Tetrahedron, 2010, 66, 1261.

1. Zhengwang Chen, Jinghao Li, Huanfeng Jiang, Shifa Zhu, Yibiao Li and Chaorong Qi, Silver-Cataly- zed Difunctionalization of Terminal Alkynes: Highly Regio- and Stereoselective Synthesis of (Z)-β-Haloenol Acetates, Org. Lett., 2010, 12, 3262.