讲座预告 | 法国巴黎高科化学学院李敏慧教授：AIE polymer micelles and vesicles as photocatalysts

报告题目：AIE polymer micelles and vesicles as photocatalysts

报  告 人：Min-Hui LI (李敏慧)（巴黎高科化学学院）

邀  请 人：秦安军 教授

报告时间：2026年10月13日（周二）下午15:00-16:30

报告地点：北区发光材料与器件全国重点实验室501会议室

报告摘要：

Biocatalytic transformations are increasingly important for green synthesis, but their integration with photocatalysis is limited by enzyme degradation from reactive oxygen species (ROS). We developed core–shell polymer micelles and vesicles with embedded organic AIE luminophores that act as visible-light photocatalysts[1]. These colloids efficiently regenerate NAD+ from NADH while protecting enzymes from ROS, enabling stable, recyclable photobiocatalysis under aerobic conditions with potential for industrial application.

Beyond synthesis, NADH/NAD+ cofactors are central to cellular metabolism, and their disruption can impair cancer cell viability. Remarkably, our AIE polymer colloids catalyze NADH/NAD+ interconversion even under oxygen-deficient conditions, bypassing common electron acceptors. In vitro and in vivo studies show that under hypoxia, these colloids induce severe NAD+/NADH imbalance, suppressing oxidative phosphorylation and glycolysis, and triggering energy crisis in 4T1 cancer cells and tumors[2]. These findings highlight their promise for hypoxia-targeted cancer phototherapy.

References: 

[1] N. Zhang, S. Trepout, H. Chen, M. H. Li, J. Am. Chem. Soc. 2023, 145, 288.

[2] Y. Ma, Y. Deng, W. Xue, X. Ji, M.-H. Li, J. Am. Chem. Soc., 2025, 147, 26557.

报告人简介

Min-Hui Li is a 1st class Research Director at the French National Centre for Scientific Research (CNRS), currently based at the École Nationale Supérieure de Chimie de Paris (Chimie ParisTech, PSL University).

Education: 

B.Sc. (1986) and M.Sc. (1988), Tsinghua University, Beijing; 

Ph.D. (1993), Pierre and Marie Curie University (now Sorbonne University), Paris. Doctoral research at Laboratoire Léon Brillouin, CEA Saclay in France.

Career: 

Postdoctoral researcher (1993-1994), French Institute of Petroleum. 

Joined CNRS in 1994 as a tenured researcher. Positions held at Centre de Recherche Paul Pascal, Bordeaux (1994–1997), Institut Curie, Paris (1997–2014), and Chimie ParisTech since 2015.

Research Focus: Soft matter chemistry; liquid crystal polymers and elastomers; amphiphilic polymers; polymer self-assembly for functional soft materials; photosensitive polymers; polymer nanoparticles with aggregation-induced emission.