关于举行中科院城市环境研究所张洪武研究员和香港浸会大学Dr. Ka-Leung Wong学术报告的通知
2017-05-19
149
一、
报告题目：长余辉纳米发光探针研发及其在活体成像中的应用
报告人：张洪武 研究员
主持人：彭明营 教授
报告时间：5月22日（星期一）15:00
报告地点：国重402会议室
报告摘要：
发光成像由于其具有原位实时以及高灵敏度的优势在生物成像中得到广泛应用，但生物体自发光现象噪声成像信噪比低，限制发光成像在生物体疾病检测中的进一步应用。长余辉发光成像由于是利用长余辉纳米发光颗粒在体外蓄光，注射体内缓慢释放发光成像的方法，这就可以避免了由于外界光源照射所产生的生物体自发光的影响，因而增强了成像的信噪比。
我们的研究工作中，我们采用多种方法合成长余辉纳米颗粒，并通过对颗粒表面进行靶向修饰，形成对生物体病灶的靶向定位，并利用近红外光原位激发的方法实现了对病灶超长时间成像检测，这有利于对疾病成因、发展过程以及转移途径进行深入探究，从而形成有效治疗。同时，我们的研究也关注于细颗粒物进入生物体后对生物体所产生的影响，结合光学成像与代谢组学研究细颗粒物在体内迁移过程以及所产生的危害。
我们的研究工作中，我们采用多种方法合成长余辉纳米颗粒，并通过对颗粒表面进行靶向修饰，形成对生物体病灶的靶向定位，并利用近红外光原位激发的方法实现了对病灶超长时间成像检测，这有利于对疾病成因、发展过程以及转移途径进行深入探究，从而形成有效治疗。同时，我们的研究也关注于细颗粒物进入生物体后对生物体所产生的影响，结合光学成像与代谢组学研究细颗粒物在体内迁移过程以及所产生的危害。
报告人简介：
张洪武，中国科学院城市环境研究所研究员，研究方向：光学成像传感以及纳米生物效应方面的研究。2005年于中国科学院大连化学物理研究所获得博士学位，先后在日本产业综合研究所原位诊断实验室以及生产计测中心从事研究工作，于2010年获得中国科学院百人计划的资助，进入中国科学院城市环境研究所进行研究工作，2013年获得福建省百人计划的资助。目前研究组主要集中于长余辉纳米探针成像诊断以及疾病靶向治疗方面的研究，到目前为止已发表学术论文90余篇，其中第一及通讯作者SCI论文73篇。
二、
报告题目：Biocompatible lanthanide materials for tumors targeting, imaging and inhibition
报告人：Dr. Ka-Leung Wong
主持人：彭明营 教授
报告时间：5月22日（星期一）15:00
报告地点：国重402会议室
报告摘要：
One of the major limitations of the existing anticancer agents is their differentiation of cancer cells and normal cells. Recently, some studies in the literature have suggested that some overexpressed cancer cell cycle regulating proteins (e.g. Cyclin(s), Plk1 and EBNA1) can be the particular cancer targets. Several small molecules as their inhibitors have been reported; however, those reported inhibitors are not emissive and cannot directly evaluate their effectiveness, such as real time imaging, biodistribution and pharmacokinetic studies. Over the recent two decades, luminescent lanthanide materials have shown extensive applications in the detection of various bioactive molecules and for in vitro/in vivo imaging, addressing the problem of autofluorescence. For this reason, one of our driving forces for synthesizing new lanthanide materials for imaging these cell cycle regulated protein relates to their unique photophysical properties, such as long emission lifetimes (effective elimination of biological auto-fluorescence in time-resolved spectroscopy) and characteristic hypersensitive emissions, (providing real-time information about the effect on coordination environment by surrounding entities, especially with europium) which are attractive substitutes to the more commonly used organic fluorophores.
In this seminar, I would like to share our development recently on emissive lanthanide materials as dual bioprobes for in vitro/in vivo imaging and inhibition of overexpressed tumor regulator proteins, such as Cyclin(s), Plk1 and EBNA1. It is hoped that the success in research could also lead to the success in practice, thereby providing more powerful tools to get more complete pictures of the roles of Cyclin(s)/Plk1/EBNA1.
In this seminar, I would like to share our development recently on emissive lanthanide materials as dual bioprobes for in vitro/in vivo imaging and inhibition of overexpressed tumor regulator proteins, such as Cyclin(s), Plk1 and EBNA1. It is hoped that the success in research could also lead to the success in practice, thereby providing more powerful tools to get more complete pictures of the roles of Cyclin(s)/Plk1/EBNA1.
报告人简介：
Curriculum Vitae (KL Wong)
i) Name: Dr. Ka-Leung Wong
ii) Academic qualification:
2002-2006 Ph.D in Chemistry, The University of Hong Kong
1999-2002 BSc in Applied Chemistry, City University of Hong Kong
iii) Previous academic positions held:
2013-2016, Assistant Professor, Department of Chemistry, Hong Kong Baptist University, HK;
2011-2013, Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University, HK;
2009-2010, Replacement Assistant Professor, Department of Chemistry, Hong Kong Baptist University, HK;
2008-2009, Royal Society Post-Doctoral Research Fellow, Department of Chemistry, Durham University, UK.
iv) Present academic position:
2016-Present, Associate Professor, Department of Chemistry, Hong Kong Baptist University, HK
v) Previous relevant research work:
Lanthanide Chemistry, Multi-Photon-, NLO-Spectroscopy and Molecular Imaging
vi) Publication records: >100 publications (, h-index = 33, citations > 2600)
A. Five representative publications in the recent five-year period
1. Lijun Jiang, Rongfeng Lan, Tao Huang, Chi-Fai Chan, Hongguang Li, Sam Lear, Jingyi Zong, Wing-Yan Wong, Magnolia Muk-Lan Lee, Brandon Dow Chan, Wai-Lun Chen, Wai-Sum Lo, Nai-Ki Mak,* Maria Li Lung, Graham S. Taylor, Zhao-Xiang Bian, William C. S. Tai, Ga-Lai Law,* Wing-Tak Wong,* Steven L. Cobb,* and Ka-Leung Wong,* ‘Targeting EBNA1: A Therapeutic Approach for EBV-related Tumour with Tailor Responsive Optical Imaging’, Nature Biomedical Engineering, (2017) 0042.
2. Aline Nonat, Chi Fai Chan, Tao Liu, Carlos Platas-Iglesias, Zhenyu Li, Wing-Tak Wong,* Wai-Kwok Wong, Ka-Leung Wong,* and Loïc J. Charbonnièrea* ‘Room Temperature Molecular Up-conversion in Solution’, Nature Communications, (2016) 11978.
3. Zhenhao Liang, Tik-Hung Tsoi, Chi-Fai Chan, Lixiong Dai, Yudan Wu, Guangyan Du, Lizhi Zhu, Chi-Sing Lee, Wing-Tak Wong, Ga-Lai Law and Ka-Leung Wong,* ‘A Smart “off-on” Gate for In-Situ Detection of Hydrogen Sulphide with Cu(II)-Assisted Europium Emission’, Chemical Science, 7 (2016) 2151-2156.
4. Hongguang Li, Rongfeng Lan, Chi-Fai Chan, Lijun Jiang, Lixiong Dai, Daniel W. J. Kwong, Michael Hon-Wah Lam and Ka-Leung Wong,*‘Real-time In Situ Monitoring via Europium Emission of the Photo-release of Antitumor Cisplatin from a Eu–Pt Complex’, Chemical Communications, 51 (2015) 14022-14025. (Inside front cover)
5. Tao Zhang, Rongfeng Lan, Chi-Fai Chan, Ga-Lai Law, Wai-Kwok Wong and Ka-Leung Wong,* ‘In Vivo Selective Cancer Tracking Gadolinium Eradicator as New Generation Photodynamic Therapy Agent’, Proceedings of National Academy of Science USA, 111 (2014) E5492-E5497.
B. Five representative publications beyond the recent five-year period
1. Lijun Jiang, Lui-Lai Lau, Hongguang Li, Chi-Fai Chan, Rongfeng Lan, Wai-Lun Chan, Terrence Chi-Kong Lau, George Sai-Wah Tsao, Nak-Ki Mak and Ka-Leung Wong,* ‘EBNA1 Specific Luminescence Small Molecules for Imaging and Inhibition of Latently EBV-infected Tumor Cells’, Chemical Communications, 50 (2014) 6517-6519.
2. Tao Zhang, Chi-Fai Chan, Rongfeng Lan, Hongguang Li, Ni-Ki Mak, Wai-Kwok Wong and Ka-Leung Wong,* ‘Porphyrin-based Ytterbium Complexes Targeting Anionic Phospholipid Membranes as Selective Biomarkers for Cancer Cell Imaging’, Chemical Communications, 49 (2013) 7258-7260.
3. Jing-Xing Zhang, Hongguang Li, Chi-Fai Chan, Rongfeng Lan, Wai-Lun Chan, Ga-Lai Law, Wai-Kwok Wong and Ka-Leung Wong,* ‘A Potential Water-Soluble Ytterbium-Based Porphyrin-Cyclen Dual Bio-Probe for Golgi apparatus Imaging and Photodynamic Therapy’, Chemical Communications, 48 (2012) 9646-9648.
4. Hoi-Kwan Kong, Francis L. Chadbourne, Ga-Lai Law, C. Y.-T. Ko, Hoi-Lam Tam, Steven L. Cobb, Chi-Kong Lau, Chi-Sing Lee and Ka-Leung Wong*, ‘Two-photon induced responsive f-f emissive detection for Cyclin A with a europium- chelating peptide’, Chemical Communications, 47 (2011) 8052-8054.
5. Tao Zhang, Xunjin Zhu, Wai-Ming Kwok, Chris T.-L. Chan, Hoi-Lam Tam, Wai-Kwok Wong and Ka-Leung Wong,* ‘Highly Water Soluble and Impressive NIR to NIR Ytterbium Emission in Mitochondria of Living Cells’, Journal of the American Chemistry Society, 50 (2011) 20120-20122.
i) Name: Dr. Ka-Leung Wong
ii) Academic qualification:
2002-2006 Ph.D in Chemistry, The University of Hong Kong
1999-2002 BSc in Applied Chemistry, City University of Hong Kong
iii) Previous academic positions held:
2013-2016, Assistant Professor, Department of Chemistry, Hong Kong Baptist University, HK;
2011-2013, Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University, HK;
2009-2010, Replacement Assistant Professor, Department of Chemistry, Hong Kong Baptist University, HK;
2008-2009, Royal Society Post-Doctoral Research Fellow, Department of Chemistry, Durham University, UK.
iv) Present academic position:
2016-Present, Associate Professor, Department of Chemistry, Hong Kong Baptist University, HK
v) Previous relevant research work:
Lanthanide Chemistry, Multi-Photon-, NLO-Spectroscopy and Molecular Imaging
vi) Publication records: >100 publications (, h-index = 33, citations > 2600)
A. Five representative publications in the recent five-year period
1. Lijun Jiang, Rongfeng Lan, Tao Huang, Chi-Fai Chan, Hongguang Li, Sam Lear, Jingyi Zong, Wing-Yan Wong, Magnolia Muk-Lan Lee, Brandon Dow Chan, Wai-Lun Chen, Wai-Sum Lo, Nai-Ki Mak,* Maria Li Lung, Graham S. Taylor, Zhao-Xiang Bian, William C. S. Tai, Ga-Lai Law,* Wing-Tak Wong,* Steven L. Cobb,* and Ka-Leung Wong,* ‘Targeting EBNA1: A Therapeutic Approach for EBV-related Tumour with Tailor Responsive Optical Imaging’, Nature Biomedical Engineering, (2017) 0042.
2. Aline Nonat, Chi Fai Chan, Tao Liu, Carlos Platas-Iglesias, Zhenyu Li, Wing-Tak Wong,* Wai-Kwok Wong, Ka-Leung Wong,* and Loïc J. Charbonnièrea* ‘Room Temperature Molecular Up-conversion in Solution’, Nature Communications, (2016) 11978.
3. Zhenhao Liang, Tik-Hung Tsoi, Chi-Fai Chan, Lixiong Dai, Yudan Wu, Guangyan Du, Lizhi Zhu, Chi-Sing Lee, Wing-Tak Wong, Ga-Lai Law and Ka-Leung Wong,* ‘A Smart “off-on” Gate for In-Situ Detection of Hydrogen Sulphide with Cu(II)-Assisted Europium Emission’, Chemical Science, 7 (2016) 2151-2156.
4. Hongguang Li, Rongfeng Lan, Chi-Fai Chan, Lijun Jiang, Lixiong Dai, Daniel W. J. Kwong, Michael Hon-Wah Lam and Ka-Leung Wong,*‘Real-time In Situ Monitoring via Europium Emission of the Photo-release of Antitumor Cisplatin from a Eu–Pt Complex’, Chemical Communications, 51 (2015) 14022-14025. (Inside front cover)
5. Tao Zhang, Rongfeng Lan, Chi-Fai Chan, Ga-Lai Law, Wai-Kwok Wong and Ka-Leung Wong,* ‘In Vivo Selective Cancer Tracking Gadolinium Eradicator as New Generation Photodynamic Therapy Agent’, Proceedings of National Academy of Science USA, 111 (2014) E5492-E5497.
B. Five representative publications beyond the recent five-year period
1. Lijun Jiang, Lui-Lai Lau, Hongguang Li, Chi-Fai Chan, Rongfeng Lan, Wai-Lun Chan, Terrence Chi-Kong Lau, George Sai-Wah Tsao, Nak-Ki Mak and Ka-Leung Wong,* ‘EBNA1 Specific Luminescence Small Molecules for Imaging and Inhibition of Latently EBV-infected Tumor Cells’, Chemical Communications, 50 (2014) 6517-6519.
2. Tao Zhang, Chi-Fai Chan, Rongfeng Lan, Hongguang Li, Ni-Ki Mak, Wai-Kwok Wong and Ka-Leung Wong,* ‘Porphyrin-based Ytterbium Complexes Targeting Anionic Phospholipid Membranes as Selective Biomarkers for Cancer Cell Imaging’, Chemical Communications, 49 (2013) 7258-7260.
3. Jing-Xing Zhang, Hongguang Li, Chi-Fai Chan, Rongfeng Lan, Wai-Lun Chan, Ga-Lai Law, Wai-Kwok Wong and Ka-Leung Wong,* ‘A Potential Water-Soluble Ytterbium-Based Porphyrin-Cyclen Dual Bio-Probe for Golgi apparatus Imaging and Photodynamic Therapy’, Chemical Communications, 48 (2012) 9646-9648.
4. Hoi-Kwan Kong, Francis L. Chadbourne, Ga-Lai Law, C. Y.-T. Ko, Hoi-Lam Tam, Steven L. Cobb, Chi-Kong Lau, Chi-Sing Lee and Ka-Leung Wong*, ‘Two-photon induced responsive f-f emissive detection for Cyclin A with a europium- chelating peptide’, Chemical Communications, 47 (2011) 8052-8054.
5. Tao Zhang, Xunjin Zhu, Wai-Ming Kwok, Chris T.-L. Chan, Hoi-Lam Tam, Wai-Kwok Wong and Ka-Leung Wong,* ‘Highly Water Soluble and Impressive NIR to NIR Ytterbium Emission in Mitochondria of Living Cells’, Journal of the American Chemistry Society, 50 (2011) 20120-20122.
vii) Others
International Scientific Award
1.The European Rare Earth and Actinide Society, 2015 ERES Junior award
2.President’s Award for Outstanding Young Researcher 2017 (Hong Kong Baptist University)
International Scientific Award
1.The European Rare Earth and Actinide Society, 2015 ERES Junior award
2.President’s Award for Outstanding Young Researcher 2017 (Hong Kong Baptist University)
Professional Appointment
1.International Advisory Board Member – ChemPlusChem, Wiley 2016-2019
1.International Advisory Board Member – ChemPlusChem, Wiley 2016-2019
Book Chapter
1.Michael Hon Wah Lam, Ga-Lai Law, Chi-Sing Lee and Ka-Leung Wong, “Organic Molecules for Imaging”, Nicholas Long and Wing-Tak Wong, editors. In: The Chemistry of Molecular Imaging. Wiley Publishing. (2014) ISBN 978-1-118-09327-6;
2.Wai-Lun Chan ZhenYu Liu and Ka-Leung Wong, “Persistent Luminescence Nanomaterials for Biomedical Applications: A Quick Grasp of the Trend”, Ru-Shi Liu editor. Springer (2016) Phosphors, Up Conversion Nano Particles, Quantum Dots and Their Applications. DOI: 10.1007/978-981-10-1590-8_11; ISBN 978-981-10-1589-2
1.Michael Hon Wah Lam, Ga-Lai Law, Chi-Sing Lee and Ka-Leung Wong, “Organic Molecules for Imaging”, Nicholas Long and Wing-Tak Wong, editors. In: The Chemistry of Molecular Imaging. Wiley Publishing. (2014) ISBN 978-1-118-09327-6;
2.Wai-Lun Chan ZhenYu Liu and Ka-Leung Wong, “Persistent Luminescence Nanomaterials for Biomedical Applications: A Quick Grasp of the Trend”, Ru-Shi Liu editor. Springer (2016) Phosphors, Up Conversion Nano Particles, Quantum Dots and Their Applications. DOI: 10.1007/978-981-10-1590-8_11; ISBN 978-981-10-1589-2
US Patent
1.“Selective Cancer Tracking Eradicator and The Uses Thereof”, Ka-Leung Wong, Wai-Kwok Wong, Rongfeng Lan and Tao Zhang, PCT Application No. PCT/CN2015/094149; Claiming Priorities of US Provisional Application No. 62/077,312 & 14/934,140. (published on 12 May 2016, 14/934,140)
1.“Selective Cancer Tracking Eradicator and The Uses Thereof”, Ka-Leung Wong, Wai-Kwok Wong, Rongfeng Lan and Tao Zhang, PCT Application No. PCT/CN2015/094149; Claiming Priorities of US Provisional Application No. 62/077,312 & 14/934,140. (published on 12 May 2016, 14/934,140)
Provisional US Patent Application
1.“Therapeutic Inhibitor for EBV-related Tumor with Tailor Responsive Optical Imaging”, Ka-Leung Wong, Nai-Ki Mak and Lijun Jiang, US Provisional Patent filing no: US62/327,504 (26 April 2016);
2.“Lanthanide Toolbox for Organelle Specific Molecular Imaging”, Ka-Leung Wong, Huanggong Li, Rongfeng Lan and Chi-Fai Chan, US Provisional Patent filing no: US62/342,603 (27 May 2016).
1.“Therapeutic Inhibitor for EBV-related Tumor with Tailor Responsive Optical Imaging”, Ka-Leung Wong, Nai-Ki Mak and Lijun Jiang, US Provisional Patent filing no: US62/327,504 (26 April 2016);
2.“Lanthanide Toolbox for Organelle Specific Molecular Imaging”, Ka-Leung Wong, Huanggong Li, Rongfeng Lan and Chi-Fai Chan, US Provisional Patent filing no: US62/342,603 (27 May 2016).
Research Funding (> HK4M)
General Research Fund/Early Career Scheme
1.2016/2017 (HKBU 12309516)
Title: The Lanthanide Toolbox as Multi-modal, Non-invasive Tumor Specific Theranostic Prodrug
Project Fund: HK$816,340
General Research Fund/Early Career Scheme
1.2016/2017 (HKBU 12309516)
Title: The Lanthanide Toolbox as Multi-modal, Non-invasive Tumor Specific Theranostic Prodrug
Project Fund: HK$816,340
2.2015/2016 (HKBU 22301615)
Title: Responsive Luminescence Lanthanide Bioprobes for ImagingV& Inhibition of Overexpressed Proteins in Cancer
Project Fund: HK$870,170
Title: Responsive Luminescence Lanthanide Bioprobes for ImagingV& Inhibition of Overexpressed Proteins in Cancer
Project Fund: HK$870,170
3.2013/2014 (HKBU 203013)
Title: Fundamentals to Applications: The Practical Luminescence Lanthanide Toolbox for Imaging of Key Cell Cycle Regulators (Plk1) and Inhibition of Tumor Cells
Project Fund: HK$974,193
Title: Fundamentals to Applications: The Practical Luminescence Lanthanide Toolbox for Imaging of Key Cell Cycle Regulators (Plk1) and Inhibition of Tumor Cells
Project Fund: HK$974,193
4.2012 / 2013 (HKBU 203012)
Title: Selective and Responsive Lanthanide/Peptide Based True Dual Probe for Cyclin A/D
Project Fund: HK$497,750
Title: Selective and Responsive Lanthanide/Peptide Based True Dual Probe for Cyclin A/D
Project Fund: HK$497,750
5.Hong Kong Innovation and Technology Fund (Tier 3 Project Scheme)
2016/2017(ITS/286/15)
Title: New Generation Photodynamic Therapy Agents for Bladder Cancer
Project Fund: HK$959,999
2016/2017(ITS/286/15)
Title: New Generation Photodynamic Therapy Agents for Bladder Cancer
Project Fund: HK$959,999
