关于举行北京大学张文彬教授学术报告的通知
报告题目：Genetically Encoded “Click” Chemistry: From Chemical Toolbox to Bioactive Materials
报告人：张文彬教授（北京大学）
报告时间：2016年1月15日下午3:30
报告地点：北区国重502报告厅
报告摘要：
The spontaneous formation of an isopeptide bond between a peptide tag and its protein partner is a genetically encoded, cell-compatible, highly specific and efficient chemistry for protein/peptide conjugation.1 Through protein engineering, we have successfully expanded the chemical toolbox of genetically encoded chemical reactions with various features. In this talk, I will present our recent results on new features introduced into the system and their application in generating intriguing bioactive materials, which includes the development of different ways to encode the same reaction, the synthesis of intriguing protein topologies, and the preparation of an all-protein-based “network of spies”.
Reference
Zakeri, B.; Fierer, J. O.; Celik, E.; Chittock, E. C.; Schwarz-Linek, U.; Moy, V. T.; Howarth, M. Natl. Acad. Sci. USA 2012, 109, E690.
Zhang, W.-B.; Sun, F.; Tirrell, D. A.; Arnold, F. H. Am. Chem. Soc. 2013, 135, 13988.
Sun, F.; Zhang, W.-B.; Mahdavi, A.; Arnold, F. H.; Tirrell, D. A. Natl. Acad. Sci. USA 2014, 111, 11269-11274
报告人简介：
Wen-Bin Zhang
Key Laboratory of Polymer Chemistry & Physics of Ministry of Education,
Center for Soft Matter Science and Engineering,
College of Chemistry and Molecular Engineering, Peking University
Beijing, 100871, China
Phone/Fax: (+86)-10-6276-6876
E-mail: wenbin@pku.edu.cn
URL: http://www.chem.pku.edu.cn/zhangwb/
Research interests:
Giant molecules based on molecular nanoparticles; protein-based biomaterials; catassembly of macromolecules
Biographic description:
Wen-Bin Zhang is currently an Assistant Professor at the Department of Polymer Science and Engineering, College of Chemistry and Molecular Engineering of Peking University. He received his B.S. in Organic Chemistry from Peking University and his Ph.D. in Polymer Science from the University of Akron. He continued at the University of Akron for his postdoctoral research under the supervision of Prof. Stephen Cheng for one year, before he moved to Caltech for a second postdoctoral training with Prof. David Tirrell in Protein Engineering and Biomaterials. His current research interests include the rational development of materials that bridges synthetic systems and biological systems for energy and health-related applications.
