关于德克萨斯大学陈伟教授学术报告的通知

2013-11-07 95

关于德克萨斯大学陈伟教授学术报告的通知

报告题目：Investigation of Luminescence Nanoparticles For Cancer Studies and Radiation Detection

报告人：德克萨斯大学陈伟教授

报告时间：2013年11月20日上午10点

报告地点：光电楼二楼会议室

报告摘要：

In this talk, I will introduce my research on using afterglow nanoparticles like ZnS:Cu,Co as light source for photodynamic activation on cancer treatment and the investigation of energy transfer nanomaterials for radiation detection. Cancer is a class of diseases in which a group of cells display uncontrolled growth. Every year, about 562,340 Americans are expected to die of cancer, more than 1,500 people a day. Cancer is the second most common cause of death in the US, exceeded only by heart disease. Early detection and effective treatment are the best hope for cancer patients. Photodynamic therapy (PDT) is a promising recipe for cancer treatment. However, the difficulty of light penetration into deep tissue has hitherto prevented the application of photodynamic therapy for deep cancer treatment. The three components that are required for PDT are oxygen, photosensitizers, and light. To solve the problem of light penetration and to enhance the PDT treatment for deep cancers, I have proposed a new PDT system in which the light is provided by afterglow nanoparticles with attached photosensitizers. When the nanoparticle-photosensitizer conjugates are targeted to tumor and stimulated by X-ray during radiotherapy, the particles will generate light to activate the photosensitizers for photodynamic therapy. Therefore, the radiation and photodynamic therapies are combined and occur simultaneously, and the tumor destruction will be more efficient. More importantly, it can be used for deep tumor treatment as X-ray can penetrate deep into the tissue such as Breast and prostate cancers. This novel modality is called nanoparticle self-lighting photodynamic therapy (NSLPDT).In this presentation, I will report the progress of the research in my group on the design, synthesis and evaluation of nanoparticle conjugates for photodynamic therapy.

In the second part of my talk, I will concentrate on nanomaterials for radiation detection. As an example, ZnO nanoparticles have a strong photoluminescence but weak scintillation luminescence which is an issue for their applications in radiation detection and dosimetry. To enhance their luminescence, ZnO nanoparticles were made into nanocomposites with CeF₃nanoparticles. As a result of energy transfer from CeF₃nanoparticles in the composites, the photoluminescence of ZnO nanoparticles is enhanced 30 times and their X-ray luminescence is enhanced 4 times. The combination of CeF₃ and ZnO nanoparticles makes CeF₃/ZnOnanocomposites promising scintillators for radiation detection.