关于举行美国麻省大学韩纲教授学术报告的通知

2018-12-03 401

报告题目：From Molecule to Mammal: Inventing Luminescent Nanoparticles for Biology

报告人：韩纲教授（美国麻省大学）

邀请人：秦安军教授

报告时间：2018年12月6日（周四）下午16:00

报告地点：北区发光材料与器件国重 502会议室

报告摘要：

Functional luminescent nanoparticles are promising materials for in vitro and in vivo optical imaging and therapy due to their unique optical and chemical properties. In this talk, I will present a series of biocompatible luminescence nanoparticles. The first type of materials is upconversion nanoparticles (UCNPs). I will present new developments regarding engineering UCNPs towards optogenetic applications¹ in neuro-engineering and cancer immunotherapy². The second type of nanoparticles is persistent luminescence nanoparticles (PLNPs).³ They are bioluminescence-like and possess unprecedented in vivo deep tissue energy rechargeability, outstanding signal-to-noise-ratio with no need for an excitation resource (light) during imaging, and they can be directly detected with existing imaging systems. These nanoparticles continue to emit light for minutes or hours and, in some cases, days, after turning off the excitation source. These long-lasting, light-emitting nanocrystals can provide noninvasive imaging technology for evaluating structural and functional biological processes in living animals and patients. The third is a type of organic Biodpy nanoparticles that were tailored with outstanding NIR absorbing ability. Rather than the conventional laser light needed in PDT, I will present their ultralow power lamp operable PDT applications in deep tissue tumor treatment.⁴ Finally, I would like also to introduce a new organic upconversion system for in vivo anticancer release. ⁵

References

Wu, X.; Zhang, Y.; Takle, K.; Bilsel, O.; Li, Z.; Lee, H.; Zhang, Z.; Li, D.; Fan, W.; Duan, C.; Chan, E. M.; Lois, C.; Xiang, Y.; Han, G., Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano 2016, 10 (1), 1060-6.
He, L.; Zhang, Y.; Ma, G.; Tan, P.; Li, Z.; Zang, S.; Wu, X.; Jing, J.; Fang, S.; Zhou, L., Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. Elife 2015, 4, e10024.
(a) Li, Z.; Zhang, Y.; Wu, X.; Maudgal, R.; Zhang, H.; Han, G., In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO2/ZnGa2O4:Cr(3+) Persistent Luminescence Nanocomposites. Adv Sci (Weinh) 2015, 2 (3); (b) Li, Z.; Zhang, Y.; Wu, X.; Huang, L.; Li, D.; Fan, W.; Han, G., Direct Aqueous-Phase Synthesis of Sub-10 nm “Luminous Pearls” with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence. J Am Chem Soc 2015, 137 (16), 5304-7.
(a) Huang, L.; Li, Z.; Zhao, Y.; Zhang, Y.; Wu, S.; Zhao, J.; Han, G., Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy. J Am Chem Soc 2016, 138(44), 14586-14591; (b) Huang, L.; Li, Z.; Zhao, Y.; Yang, J.; Yang, Y.; Pendharkar, A. I.; Zhang, Y.; Kelmar, S.; Chen, L.; Wu, W.; Zhao, J.; Han, G., Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles. Adv Mater 2017, 29 (28).
Huang, L.; Zhao, Y.; Zhang, H.; Huang, K.; Yang, J.; Han, G., Expanding Anti-Stokes Shifting in Triplet-Triplet Annihilation Upconversion for In Vivo Anticancer Prodrug Activation. Angew Chem Int Ed Engl 2017, 56(46), 14400-14404.

个人简介：

韩纲，University of Massachusetts-Medical School，生物化学与分子药理学系，副教授。南京大学化学专业本科和硕士，美国UMASS-Amherst分校化学系获博士学位，劳仑斯伯克利国家实验室分子工厂纳米中心博士后。主要在研方向是为：新颖纳米材料的光遗传学神经调控和免疫医学治疗以及面向临床转化的新颖分子成像应用，已在Nature, Nat Nanotech, Nat Communications, Elife, PNAS, Nano Letter, ACS Nano, JACS, Angew Chem, Advanced Materials, Small, 等杂志上发表了80余篇学术论文。很多工作被选作焦点文章，封面文章，或被媒体报道。获得伍斯特基金会梅尔·卡特勒奖、美国NIH “尤利卡”创新奖、HFSP人类前沿科学项目青年调查员奖、麻省大学医学院临床与转化科学奖项、Alex’s创新奖等。受邀作为美国NIH 和国防部（DOD ）专家评审，脑健康提案评审。担任Nat Mater, Nature Nano, Nano Letter, Angew Chem, JACS, Adv Mater等80余本杂志审稿人。所发表论文当前被SCI 期刊引用超过9400次