Duan Yuyou, Ph.D, Professor
School of Medicine
South China University of Technology
Member of International Society for Stem Cell Research
Member of American Association for the Study of Liver Diseases
Editor for Gastroenterology & Hepatology International Journal
Editor for Juniper Online Journal of Immunovirology
Editorial Board member for Journal of Blood Transfusion and Hematopathology
Editorial Board member for Journal of Gastroenterology, Liver & Pancreatic Diseases
Editorial Board member forJournal of Hepatology & Gastroenterology
Education
1994 - 1997 Ph.D, Changchun University of Agriculture and Animal Science
1988 - 1991 MS, Yangzhou University
1984 - 1988 BS, Yangzhou University
Working Experiences
2017 – Present Professor, Institutes for Life Sciences, School of Medicine, China South
University of Technology, Guangzhou, China.
2015 - 2017 Associate Professor, Department Dermatology, Institute for
Regenerative Cures, UC Davis Medical Center, Sacramento, California,
USA
2011 - 2015 Assistant Professor, Department of Dermatology, Institute for
Regenerative Cures, Department of Internal Medicine, UC Davis
Medical Center, Sacramento, California, USA
2008 - 2010 Assistant Project Scientist, Department of Internal Medicine, UC Davis
Medical Center, Sacramento, California, USA
2005 - 2008 Staff Research Associate, Department of Internal Medicine, UC Davis
Medical Center, Sacramento, California, USA
2000 - 2004 Postdoctoral Fellow, Department of Internal Medicine, UC Davis
Medical Center, Sacramento, California, USA
1999 - 2000 Postdoctoral Fellow, College of Veterinary Medicine, Cornell University,
Ithaca, New York, USA
1997 - 1999 Associate Professor, College of Veterinary Medicine, Yangzhou
University, Yangzhou, Jiangsu, China
1994 - 1997 Assistant Professor, College of Veterinary Medicine, Yangzhou
University, Yangzhou, Jiangsu, China
1991 - 1994 Research Associate, College of Veterinary Medicine, Yangzhou
University, Yangzhou, Jiangsu, China
Research Fields
Stem Cells and regenerative medicine, translational medicine, applications of stem cell-derived hepatocytes in pharmaceutical study and clinics, liver injury and regeneration, cellular origination and transformation mechanism of cancer stem cells, specific-targeting of cancer stem cells.
Achievements
Dr. Duan had led to the researches from projects funded by NIH, California Institute for Regenerative Medicine, UC Davis as principal investigator and co-investigator, and major contributions from these researches include developing highly efficient differentiation of functioning hepatocytes from human pluripotent stem cells with almost homogenous population which can be used in clinics and pharmaceutical industry, revealing that WNT and MAPK/ERK signaling pathways co-regulate the differentiation of human embryonic stem cells towards hepatocytes, determining the origin and formation of a liver cancer stem cell and demonstrated the fusion is an approach of formation of human cancer stem cells, establishing clonogenically culturing and expanding of cancer stem cells in vitro,and developing gene therapy for bi-functional treatment of human alpha 1-Antitrypsin deficiency. Those findings were published in Gastroenterology、Stem Cells、Stem Cells Translational Medicine、Stem cells and Development, Liver International in over 60 papers and 30 conference proceedings. Dr. Duan was awarded with UC Davis Health System Excellent Achievement, Science and Technology Progress (2nd Class) of Ministry of Education of China, Excellent Young Core Teachers of Universities and Colleges, etc. Dr. Duan also has served over 20 journals as the editor, editorial board member and reviewer.
Selected publications:
Chen J, Tschudy-Seney B, Ma X, Zern MA, Liu P, Duan Y*. Salvianolic acid B enhances hepatic differentiation of human Embryonic Stem cells via upregulation of WNT pathway and inhibition of Notch pathway. Stem Cells Dev. 2017 Dec 19. doi: 10.1089/scd.2017.0168.
Chen J, Chen L, Zern MA, Thesie ND, Diehl AM, Liu P, Duan Y*. The diversity and plasticity of adult hepatic progenitor cells and their niche. Liver Int 2017;37(9):1260-1271.
Chen J, Wei Gao W, Zhou P, Ma X, Tschudy-Seney B, Liu C, Zern MA, Liu P, Duan Y*. Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu. Sci Rep 2016; 6:18841.
Zeng C, Y Zhang, S Park, J Eun J, N Nguyen, Y Jung, B Tschudy-Seney, ND Theise, MA Zern, Y Duan*. CD34+ Liver Cancer Stem Cells were Formed by Fusion of Hepatobiliary Stem/Progenitor Cells with Hematopoietic Precursor-Derived Myeloid Intermediates. Stem Cells Dev 2015; 24(21):2467-78.
Park S, C Zeng, B Tschudy-Seney, N Nguyen, J Eun, Y Zhang, R Ramsamooj, Y Zhang, M Zhao, ND Theise, H Zhou, MA Zern, Y Duan*. Clonogenically culturing and expanding CD34+Liver cancer stem cells in vitro. Stem Cells Dev 2015; 24(13):1506-14.
Park S, N Nguyen, J Eun, Y Zhang, Y Jung, B Tschudy-Seney, A Trotsyuk, A Lam, R Ramsamooj, Y Zhong, ND Theise, MA Zern, Y Duan*. Identification of Cancer Stem Cell Subpopulations of CD34+ PLC/PRF/5 That Result in Three Types of Human Liver Carcinomas. Stem Cells Dev 2015; 24(8):1008-21.
Gao W, P Zhou, X Ma, B Tschudy-Seney, J Chen, Y Zhang, NL Magner, MA Zern, YDuan*. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway. PLOS ONE2014; 9:e112698.
Eun J, Y Jung, Y Zhang, Y Zhang, B Tschudy-Seney, R Ramsamooj, Y Wan, ND Theise, MA Zern, Y Duan*. Hepatoma SK Hep-1 cells exhibit characteristics of oncogenic mesenchymal stem cells with highly metastatic capacity. PLOS ONE 2014; 9:e110744.
Ma X#, Y Duan#*, B Tschudy-Seney, G Roll, I Saramipoor Behbahan, T Ahuja, V Tolstikov, C Wang, J McGee, S Khoobyari, J Nolta, H Willenbring, MA Zern. Efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Stem Cells Transl Med 2013; 2:409-419.
Ghaedi M, Soleimani M, Shabani I, Duan Y*, Lotfi A. Hepatic differentiation from human mesenchymal stem cells on a novel nanofiber scaffold. Cell Mol Biol Lett 2012; 17:89-106.
Duan Y, X Ma, W Zou, C Wang, I Behbahan, T Ahuja, V Tolstikov, MA Zern. Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells. STEM CELLS 2010; 28:674-686.
Duan Y, A Canata, Y Meng, N Yamamoto, S He, S Gupta, SS Gambhir and MA Zern. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. STEM CELLS 2007; 25:3058-3068.
Duan Y, J Wu, J Zhu, S Liu, I Ozaki, D Strayer, and MA Zern. Gene therapy for human alpha 1-Antitrypsin deficiency in an animal model using SV40-derived vectors. Gastroenterology 2004; 127:1222-1232.
Phone: +86 020 3938 0950
E-mail: yuyouduan@scut.edu.cn