时间：2014年12月12日（星期五）上午10：00
地点：光通信材料研究所302会议室

报告摘要：
       Cyclin/Plk1/EBAN1, involved in many key steps throughout mitosis, is found to be of great important in cancer treatment since its activity appears to be limited to mitosis in proliferating cells. However, the lack of selective small-molecule inhibitors of the kinase remains a major obstacle to further elucidate its precise functions. For instance, using anticancer agents that target microtubules may engender various adverse effects partially because of the diverse functions of microtubules in the cell. To date, only few small molecules can show the very specificity to Cyclin/Plk1/EBAN1for imaging and inhibition. It is self-evident that the enhanced understanding of Cyclin/Plk1/EBAN1activities will considerably favour the design and implementation of future experiments in the research, preclinical, and clinical settings, adding muscle to our war against cancer.
       Although decent prognosis can be achieved by these small molecules, such chemosensors are not without disadvantages: broad emission bands, short luminescence lifetimes (~ns) and ease of photo-bleaching. In contrast, lanthanide complexes, in this regard, do surpass all their counterparts, having large Stokes shifts, sharper fingerprint emission peaks, longer emission lifetimes (~ms) and higher photo-stability. Our blueprint includes the Cyclin/Plk1/EBAN1-specific lanthanide complexes with particular peptides and chromophores that can be excited in the near infra-red region via multi-photon excitation, and, above all, be Cyclin/Plk1/EBAN1-specific.
       Herein, it will show our development of a new generation of lanthanide complexes conjugated with responsive chromophores and Cyclin/Plk1/EBAN1specific peptides as dual probes – imaging and anti-tumor. It is hoped that the success in research could also lead to the success in practice, thereby providing more powerful tools to get a more complete picture of the role of Cyclin/Plk1/EBAN1.

附主讲人简介：
       黄嘉良助理教授于2006年在香港大学获得博士学位，师从黄永德教授。2008年进入英国杜伦大学化学系进行博士后研究，导师为David Parker。2011年至2013年于香港浸会大学任研究助理教授，2013年聘为香港浸会大学助理教授。目前主要从事镧系元素化学、多光子非线性光谱学以及分子细胞成像领域的研究，至今在 J. Am. Chem. Soc., Angew. Chem. Int. Edit., Adv. Mater., Proc. Nat. Acad. Sci. USA, Chem. Mater., Chem. Commun.等一流学术期刊发表70余篇SCI论文（h指数= 24），并撰写1 篇专著章节。