Research

We are interested in natural product synthesis, target-oriented methodology development and medicinal chemistry. In particular, we are working on biologically active alkaloids and terpenes containing quaternary carbon centers. We seek to apply cycloaddition, radical cyclization, and developed cascade reactions to rapidly assemble structurally challenging architectures. We have completed asymmetric synthesis of ergostane-type steroids dankasterones A and B and periconiastone A (Angew. Chem. Int. Ed.2021, 60, 5512); divergent synthesis of skeletally distinct Monoterpenoid indole alkaloids arboridinine and arborisidine (Angew. Chem. Int. Ed.2021, 60, 26978); ; 14-step synthesis of Myrioneuron alkaloid myrioneurinol (Angew. Chem. Int. Ed.2022, 61, e202200085); Asymmetric Synthesis of Arboduridine (Angew. Chem. Int. Ed. 2024, 63, e202407127); Asymmetric Total Synthesis of Alstrostine G Utilizing a Catalytic Asymmetric Desymmetrization Strategy (Angew. Chem. Int. Ed. 2024, 63, e202316016).