报告题目：Stereoselective Construction of Challenging C-C Bonds and theDevelopment of Antimetastatic Agents

报告人：P. Andrew Evans（女王大学教授）

邀请人：黄良斌教授

报告时间：2026年11月18日（星期三）上午10：00—12：00

报告地点：五山校区逸夫工程馆105

主办单位：化学与化工学院

报告人简介：

Professor P. Andrew Evans is the Alfred R. Bader Chair of Organic Chemistry and a Tier 1 Canada Research Chair in Organic and Organometallic Chemistry in the Department of Chemistry at Queen’s University.He is also a Changjiang Scholar at Central South University in China. He received a B.Sc. with honors in Applied Chemistry at Newcastle Polytechnic in 1987 and completed his Ph.D. at the University of Cambridge in 1991 under the supervision of Andrew B. Holmes, FRS. He then pursued postdoctoral research with Philip D. Magnus, FRS, at the University of Texas at Austin as a NATO Postdoctoral Fellow. In 1993, he began his independent career at the Universityof Delaware, where he was promoted to Professor before moving to Indiana University in 2001. In 2006, he became the Heath Harrison Chair of Organic Chemistry at the University of Liverpool before assuming his current role in 2012. His recent awards include the R. U. Lemieux Award, the Paul G. Gassman Distinguished Service Award, the Harry and Carol Mosher Award, a Changjiang Scholar Award, an ACS Cope Scholar Award and the RSC Pedler Award. He has beenactively involved in the ACS Division of Organic Chemistry, serving as a Member-at-Large, Councilor, National Organic Symposium Executive Officer and Division Chair. He currently co-chairs the ACS-DOC Graduate Research Symposium.Professor Evans has served as an Associate Editor for Chemical Communications and Synthesis. He is also the former Editor-in-Chief and current President of Organic Reactions. He has published nearly 175 papers, articles, reviews, book chapters and monographs and has delivered more than 500 plenary and invited lectures.

报告摘要：

The seminar will explore thedevelopment and application of new stereoselective C-C bond-forming reactionsin the synthesis of bioactive agents. Specifically, it will highlight a noveldynamic kinetic resolution of a,b-unsaturated aldehydes,[1] the catalyticasymmetric alkylation of homoenolates[2] and the development of a concise,efficient and scalable synthesis of antimetastatic agents. [3]

References

(1) Majhi, J.; Turnbull, B. W. H.; Ryu, H.; Park, J.; Baik,M.-H.; Evans, P. A. J. Am Chem. Soc. 2019, 141, 11770. (b) Ma, J.; Li, H.;Majhi, J.; Evans, P. A. Angew. Chem. Int. Ed. 2026, e202620674.

(2) Wright, T. B.; Turnbull, B. W. H.; Evans, P. A. Angew.Chem. Int. Ed. 2019, 58, 9886. (b) Xie, H.; Hwang, D.; Yoo, S. Y.; Ma, J.;Howe, G. W.; Baik, M.-H.; Evans, P. A. “Catalytic Stereochemical Relay for theEnantioselective Synthesis of Acyclic Quaternary Stereocenters” J. Am. Chem.Soc. 2026, 148, 40651.

(3) Bhavin V. Pipaliya, B. V.; Trofimova, D. N.;Grange, R. L.; Aeluri, M.; Deng, X.; Shah, K.; Craig, A. W.; Allingham, J. S.;Evans, P. A. J. Am. Chem. Soc. 2021, 143, 6847. (b) D. N. Trofimova, M. Aeluri,K. D. Veeranna, Y. Jiang, R. L. Grange, B. V. Pipaliya, M. Subaramanian, A. W.Craig, P. A. Evans andJ. S. Allingham, J. Med. Chem. 2024, 67, 5315.