报告题目：Towards On-DemandSynthesis of Small Organic Molecules

报告人：吴杰（新加坡国立大学教授）

邀请人：黄良斌教授

报告时间：2026年1月12日（星期一）下午15：30—17：30

报告地点：五山校区造纸楼A204

主办单位：化学与化工学院

报告人简介：

Jie obtained his PhD in 2012 with Prof.James S. Panek at Boston University working on natural product total synthesis.In his postdoc research at MIT with Prof. Timothy Jamison and Prof. AlanHatton, Jie has been exposed to the hard core of continuous flow chemistry.Since joining NUS in July 2015, his research group focuses on new synthetic methodology development using photocatalysis assisted by advanced flow technologies. His group is also interested in the development of advanced flow technologies for on-demand and automated synthesis of functionalized organic molecules. In July 2021, Jie was promoted to tenured associate professor. His research group has published more than 100 papers in these research areas, with more than 10 filed patents. Jie is a recipient of Dean’s Chair Professor (2023), Tokyo Chemical Industry-SNIC Industry Award in Synthetic Chemistry (2021), NUS Young Research Award (2021), Yong Scientist Award (2020), Asian Core Program Lectureship Award(2017-2022), Thieme Chemistry Journal Award (2019), and NUS Chemistry Department Young Chemist Award (2018).

报告摘要：

Keywords: on-demand synthesis, flowchemistry, photocatalysis, multistep synthesis

“Button-push” automated synthesis of complex molecules represents one of the future goals for organic synthesis. In this talk, I will present some of our recent efforts towards this goal employing advanced flow reactors. A “stop-flow” micro-tubing (SFMT) reactor platform was invented,[1] which is especially suitable for gas involvedreactions under light irradiations. A high-speed circulation flow reactor has been developed for heterogeneous photocatalysis.[2-4] An SPS-flow system was employed to enable automated API synthesis that can deliver analogues in an on demand and button-push fashion.[5,6] In this talk, I will also introduce theNUS chemistry self-finance MSc programs.

References

[1] F. Xue, H. Deng, C. Xue, D. K. B.Mohamed, K. Y. Tang, J. Wu, Chem. Sci. 2017, 8, 3623.

[2] Liu, C.; Song, L.; Liu, Q.; Chen, W.;Xu, J.; Wang, M.; Zhang, Y.; Tan, T. W.; Lei, Z.; Cheng, L.; Khan, S. A.; Wu,J. Org. Process Res. Dev. 2024, 28, 1964-1970.

[3] Liu, T.; Li, T.; Tea, Z. Y.; Wang, C.;Shen, T.; Lei, Z.; Chen, X.; Zhang, W.; Wu, J. Nat. Chem. 2024, 16, 1705-1714.

[4] Shi, Y.; Hai, X.; Cheng, L.; Du, H.;Yu, X.; Ang, H. T.; Wu, J.; Chen, J.; Wang, G.; Lu, J.; Wu, J. Nat. Catal. 2025,DOI: 10.1038/s41929-025-01450-2.  

[5] C. Liu, J. Xie, W. Wu, M. Wang, W.Chen, S. B. Idres, J. Rong, L.-W. Deng, S. A. Khan, J. Wu, Nat. Chem. 2021, 13,451.