报告题目：“Elementary 1,4-Addition Reactions” on Nickel and Cobalt

报 告 人：周建荣（北京大学深圳研究生院教授）

报告时间：2025年6月16日（星期一）上午10：00—11：30

报告地点：化学与化工学院逸夫工程馆四楼会议室

邀 请 人：曾伟教授

主办单位：化学与化工学院/广东省功能分子重点实验室

报告人简介：

Professor Steve Zhou 1998, B.Sc. and 2000, M.Sc. in chemistry at the National University of Singapore (Supervisor: Teck-Peng Loh). 2000-2005, Ph.D. in Organic Chemistry at Massachusetts Institute of Technology (supervisor: Gregory Fu). 2005-2008, Postdoctoral researcher, Yale University and later, University of Illinois Urbana-Champaign (supervisor: John Hartwig). 2008-2019, Nanyang Assistant Professor, Senior Research Scientist, Nanyang Technological University, with joint appointment of Singapore National Research Foundation Fellow (2008-2013). Since 2019, Associate Professor, Peking University Shenzhen Graduate School. Since 2021, “Pengcheng Kongque” Program Professor of Shenzhen.

Research field: asymmetric catalytic reactions using transition metal complexes.

报告摘要：

In studies of nickel- and cobalt-catalyzed conjugate reductive arylation and alkenylation, we discovered that these reactions proceeded via a novel mechanism on 3d transition metals which we called “elementary 1,4-addition”. They are different from textbook examples of 1,2-migratory insertion on noble metals such as palladium and rhodium. Factors that contribute to this reactivity difference between 3d late metals and heavier congeners are discussed. Salient features of new methods include direct use of aryl halides and alkenyl sulfonates, mild and almost neutral conditions, excellent tolerance of polar groups and weakly acidic hydrogens groups, and scalability using low loadings of catalysts (as low as 0.1%). Asymmetric reductive arylation and alkenylation of aldehydes, ketones and imines also proceeded well.