2019.09-2025.10  South China University of Technology，Assistant Professor

2017-2019  South China University of Technology，Postdoctoral Fellow

2011-2017 University of Science and Technology of China，PhD

Nano-delivery Carriers, Tumor Immunotherapy

Professor Shen has primarily dedicated his research to the development of biological macromolecular drug delivery systems. To date, he has authored more than 50 peer-reviewed articles published in internationally renowned journals, including Nature Biomedical Engineering, Nature Communications, and Advanced Materials, accumulating over 3,500 citations. He has filed a total of 17 patents in China, the United States, and under the Patent Cooperation Treaty (PCT), with 8 patents already granted. Professor Shen has successfully secured substantial research funding by leading multiple competitive grant projects, including the Youth Science Fund (Class B) from the National Natural Science Foundation of China, the Outstanding Young Scholar Project funded by the Guangdong Provincial Natural Science Foundation, and three General Program grants awarded by the National Natural Science Foundation of China.

The Selected Publications：

1. Ya-Nan Fan, Long Zhu, Yu-Xin Qing, Si-Yi Ye,Qian-Ni Ye, Xiao-Yi Huang, Dong-Kun Zhao, Tai-Yu Tian, Fang-Chao Li, Guan-RongYan, Xian-Zhu Yang, Song Shen*, Jun Wang*, Engineering multi-specificnano-antibodies based on a versatile nano-adaptor for cancer immunotherapy, NatureBiomedical Engineering, 2025, doi: 10.1038/s41551-025-01425-5.

2.Qian-NiYe, Long Zhu, Jie Liang, Dong-Kun Zhao, Tai-Yu Tian, Ya-Nan Fan, Si-Yi Ye, HuaLiu, Xiao-Yi Haung, Zhi-Ting Cao, Song Shen*, Jun Wang*,Orchestrating NK and T cells via tri-specific Nano-Antibodies for synergisticantitumor immunity, Nature Communications, 2024, 15,6211.

3.Cheng-TaoJiang#, Kai-Ge Chen#, An Liu, Hua Huang, Ya-Nan Fan,Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen*,Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang*, Immunomodulatingnano-adaptors potentiate antibody-based cancer immunotherapy. Nature Communications, 2021, 12, 1359.

4.Hua Huang#,Qi-Song Tong#, Jing-Yang Zhang, Rong Liu, Yang Chen, Song Shen*,Jin-Zhi Du*, Jun Wang, Phagocytosis-Activating NanocomplexOrchestrates Macrophage-Mediated Cancer Immunotherapy, Advanced Materials, 2025,e2500982.

5.Jie Liang#, Dong-Kun Zhao#, Hao-Ming Yin, Tai-YuTian, Jian-Kang Kang, Song Shen*, Jun Wang, Combinatorial screening ofnanomedicines in patient-derived cancer organoids facilitates efficient cancertherapy, Nano Today, 2025, 61, 102665.

6.Boya Yu, Zekai Xiao, Shuaiqi Shao, Mingda Yang, Houjin Jing, Song Shen*,Ziyang Cao*, and Xianzhu Yang*, An Iron-Polyphenol Decorated siRNA-EncapsulatedNanomedicine Multifacetedly Promoted Macrophage Phagocytosis forSynergistic Ferroptosis-Immunotherapy, Advanced Functional Materials,2025, 2417548.

7.Zheng Zhang#, Ya-Nan Fan#, Si-Qi Jiang, Ya-JingMa, Yao-Ru Yu, Yu-Xin Qing, Qian-Ru Li, Yi-Lin Liu, Song Shen*, Jun Wang*,Recent Advances in mRNA Delivery Systems for Cancer Therapy, AdvancedScience, 2025, e17571.

8.Qi-Song Tong#,Hua Huang#, Hui-Han Yu, Rong Liu, Song Shen*, Jin-Zhi Du*, ASize-switchable Nanocluster Remodels the Immunosuppressive Microenvironment ofTumor and Tumor-draining Lymph Nodes for Improved Cancer Immunotherapy,Biomaterials,2025, 315, 122910.

9.Kai-Ge Chen#,An Liu#, Cheng-Tao Jiang, Dong-Kun Zhao, Qian-Ni Ye, Yu-Qi Liao,Cong-Fei Xu, Song Shen*, Jun Wang, Dual-functional super bispecificnano-antibodies derived from monoclonal antibodies potentiate the antitumoreffect of innate immune cells. Nano Today 2021, 39, 101209.

10.Qian-Ni Ye#,Yue Wang#, Song Shen*, Cong-Fei Xu, Jun Wang*,Biomaterials-Based Delivery of Therapeutic Antibodies for Cancer Therapy, Advanced Healthcare Materials, 2021, 2002139.