冯光雪 教授
联系方式：
办公电话：020-87113459
邮箱：fenggx@scut.edu.cn
通讯地址：广州市天河区华南理工大学北区科技园1号楼S206-6
工作经历
2019年11月 – 至今 教授，材料科学与工程学院，华南理工大学，广州
2017年8月 – 2019年7月 首席科学家，LuminiCell Pte Ltd，新加坡
2016年1月 – 2017年7月 博士后, 化学与生物分子工程系，新加坡国立大学，新加坡
教育经历
2011年8月至 2016年1月博士，化学与生物分子工程系，新加坡国立大学，新加坡
2007年8月至 2011年7月本科，化学与生物分子工程系，新加坡国立大学，新加坡
研究兴趣
1. 聚集诱导发光：聚集诱导发光材料的设计及其在传感、环境和疾病诊疗领域中的应用研究；
2. 聚集体光功能材料：基于有机光功能分子设计，通过调控介观尺度上分子聚集体材料的化学与物理构造，建立起分子-介观-宏观尺度的构效关系，精确操控其光学性能和生物学效应；
3. 分子影像：开发具有先进影像模式（如光声成像、荧光成像和余晖发光成像）的探针，检测和监测疾病微环境中的病理过程，用于诊断、治疗和预后效果评估；
4. 疾病诊疗：利用和改善肿瘤特有微环境，通过光、X射线、超声等外界刺激精准调节肿瘤活性氧水平，实现无创、可控、高效、高特异性的肿瘤治疗。
科研项目
1.华南理工大学“兴华学者计划”精英学者, 项目负责人
2.“海外高层次人才引进计划”青年项目，项目负责人
3. 广东省自然科学基金面上项目，项目负责人
1. 国家自然科学基金重大项目，2026-2030，219万，课题负责人
2. 国家自然科学基金面上项目，2025-2025，48万，项目负责人
3. 国家重点研发计划，2024-2029，99.3万，课题参与人
4. 广东省重点领域研发计划，2024-2026，120万，课题参与人
5. 国家自然科学基金-青年科学基金（青C）2023-2025，30万，项目负责人
6. 广东省卓越团队，2023-2025，50万，项目参与人
7. “海外高层次人才引进计划”青年项目，2019-2022，300万，项目负责人
8. 华南理工大学“兴华学者计划”精英学者, 2019-2024，200 万，项目负责人
9. 广东省自然科学基金面上项目，2021-2023，10万，项目负责人
10. 广州市科技厅项目，5万和10万，项目负责人
论文发表（SCI收录100余篇，引用10000余次，h因子56）
1. Yuewen Yu, Yubo Liu, Le Zhang, Congbin Fan,* Ben Zhong Tang,* and Guangxue Feng,* Construction of smart switchable nanoplatforms for adaptive phototheranostics. Chem. Soc. Rev. 2026, 55, 2325-2354.
2. Guo-Qiang Zhang,# Guangxue Feng,# Cheng Xu, Zhiyuan Gao, Jingtian Zhang, Longfei Li, Yan Zhang,* Kanyi Pu,* and Dan Ding,* Radioisotope-mimetic molecular afterglow probe for downregulated cancer biomarker imaging. Nat. Mater. 2026, https://doi.org/10.1038/s41563-026-02507-8.
3. Di Zhang, Zhiqiang Ni, Qiaoyang Tang, Jinan Li, Hao Lu, Xiangjun Gong, Yating Hu, Ben Zhong Tang, Guangxue Feng*, Light-propelled Janus-like organic nanomotors for photo-mechanical cancer therapy. Cell Bioamater. 2026, 2, 100212.
4. Qiaoyang Tang, Binghui Xue, Hanyu Jia, Yubo Liu, Ben Zhong Tang & Guangxue Feng,* A hindrance-plane-hindrance molecular engineering strategy towards self-assembled nanorods for enhanced photodynamic therapy. Nat. Commun. 2025, 16, 11292.
5. Di Zhang, Zexian Zhao, Qiaoyang Tang, Hanyu Jia, Ben Zhong Tang, and Guangxue Feng*, Phase-Transition Nanoparticles Enable Fluorescence Self-Reporting for Close-Loop Photodynamic Therapy. Angew. Chem. Int. Ed. 2025, 64, e202516764. (IF = 16.1)
6. Peirong Zhou, Di Zhang, Yingying Meng, Xiaoran Huang, Yongchuan Wu, Yuanqing Bai, Jingjing Guo, Hongwei Song, Kai Zhang, Liang Yao, Guillermo C. Bazan,* Guangxue Feng,* and Cheng Zhou,* Light-triggered molecular mechanotherapy of tumor using membrane-mimicking conjugated oligoelectrolytes. Sci. Adv. 2025, 11, ady3349.
7. Yubo Liu, Yuchen Song, Zhong-Hong Zhu, Chao Ji, Jianqing Li, Hanyu Jia, Yang Shi,* Fang Hu,* Zujin Zhao, Dan Ding, Ben Zhong Tang, and Guangxue Feng*. Twisted-Planar Molecular Engineering with Sonication-Induced J-Aggregation To Design Near-Infrared J-Aggregates for Enhanced Phototherapy. Angew. Chem. Int. Ed. 2025, 64, e202419428. (IF = 16.1)
8. Chao Chen, Xiaoyan Zhang, Zhiyuan Gao, Guangxue Feng,* and Dan Ding*, Preparation of AIEgen-based near-infrared afterglow luminescence nanoprobes for tumor imaging and image-guided tumor resection. Nat. Protocol. 2024, 19, 2408–2434. (IF = 13.1)
9. Zhaoyun Liu, Jingtian Zhang, Hui Liu, Hongli Shen, Nanhao Meng, Xinwen Qi, Kai Ding, Jia Song, Rong Fu,* Dan Ding,* and Guangxue Feng*. BSA-AIE Nanoparticles with Boosted ROS Generation for Immunogenic Cell Death Immunotherapy of Multiple Myeloma. Adv. Mater. 2023, 35, 2208692. (IF = 27.4)
10. Riqing Ding, Chao Ji, Huili Yang, Jiaqiang Liao, Feng Ye, Sijing Wang, Tianyi Dai, Lei Fang, Guangxue Feng,* and Zi-Hao Guo,* Molecular Engineering of Strong Electron-Deficient Acceptor for Constructing D-A Conjugated Polymers in NIR-II Photothermal Therapy. Small 2026, e14660.
11. Jingtian Zhang, Di Jiao, Xinwen Qi, Yufan Zhang, Xiaoang Liu, Tengwu Pan, Heqi Gao, Zhaoyun Liu,* Dan Ding,* and Guangxue Feng*. An Albumin-Photosensitizer Supramolecular Assembly with Type I ROS-Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy. Adv. Sci. 2025, 2410405. (IF = 15.1)
12. Zhong-Hong Zhu, Le Zhang, Shaorui Jia, Zhiqiang Ni, Yun-Lan Li, Hua-Hong Zou, Yutong Yang, Yating Hu,* Dan Ding,* Ben Zhong Tang, and Guangxue Feng*. Nanoscale Metal-Organic Framework Leveraging Water, Oxygen, and Hydron Peroxide to Generate Reactive Oxygen Species for Cancer Therapy. Adv. Funct. Mater. 2024, 2419548. (IF = 18.5)
13. Yuewen Yu, Le Zhang, Hanyu Jia, Chao Ji, Yucheng Liu, Zexian Zhao, Chunhui Dai, Dan Ding,* Ben Zhong Tang, and Guangxue Feng*. Dual-Mode Reactive Oxygen Species-Stimulated Carbon Monoxide Release for Synergistic Photodynamic and Gas Tumor Therapy. ACS Nano 2024, 18, 31286-31299. (IF = 15.8)
14. Yuewen Yu, Honglin Wang, Zeyan Zhuang, Chao Ji, Le Zhang, Yulu Li, Zujin Zhao, Dan Ding, Guangxue Feng,* and Ben Zhong Tang*. Self-Adaptive Photodynamic-to-Photothermal Switch for Smart Antitumor Photoimmunotherapy. ACS Nano 2024, 18, 13019−13034. (IF = 15.8)
15. Le Zhang, Yuewen Yu, Keke Ding, Chao Ji, Di Zhang, Ping Liang, Ben Zhong Tang, Guangxue Feng*. Tumor microenvironment ameliorative and adaptive nanoparticles with photothermal-to-photodynamic switch for cancer phototherapy. Biomaterials 2025, 313, 122771. (IF = 12.8)
16. Yutong Yang,Chao Ji Zhong-Hong Zhu, Yulu Li, Zhiqiang Ni, Yating Hu,* Guangxue Feng,* and Ben Zhong Tang. Metal–Organic Frameworks Based on Fluorogens with Aggregation-Induced Emission for Enhanced Sonodynamic Therapy. Chem. Mater. 2024, 36, 4955−4966. (IF = 7.2)
17. Yubo Liu, Jianqing Li, Shaokuan Gong, Yuewen Yu, Zhong-Hong Zhu, Chao Ji, Zujin Zhao, Xihan Chen, Guangxue Feng,* and Ben Zhong Tang*. Achieving beyond 100% Triplet State Generation with Singlet Fission Strategy for High-Performance Photosensitizer Design. ACS Mater. Lett. 2024, 6, 896−907. (IF = 9.9)
18. Yuewen Yu, Zihui Ni, Yanbin Xu, Le Zhang, Yucheng Liu, Fanrui Zeng, Ming Zhang,* Laikui Liu,* Guangxue Feng,* and Ben Zhong Tang*, Multi-Functional AIE Phototheranostic Agent Enhancing αPD-L1 Response for Oral Squamous Cell Carcinoma Immunotherapy. Small 2024, 2405470. (IF = 13.0)
19. Yulu Li, Di Zhang, Yuewen Yu, Le Zhang, Ling Li, Leilei Shi, Guangxue Feng,* and Ben Zhong Tang*. A Cascade Strategy Boosting Hydroxyl Radical Generation with Aggregation-Induced Emission Photosensitizers-Albumin Complex for Photodynamic Therapy. ACS Nano 2023, 17, 16993-17003. (IF = 15.8)
20. Yuewen Yu, Lisha Xiang, Xuanwei Zhang, Le Zhang, Zhiqiang Ni, Zhong-Hong Zhu, Yubo Liu, Jie Lan, Wei Liu, Ganfeng Xie,* Guangxue Feng,* and Ben Zhong Tang*. Pure Organic AIE Nanoscintillator for X-ray Mediated Type I and Type II Photodynamic Therapy. Adv. Sci. 2023, 10, 2302395. (IF = 15.1)
21. Zhiqiang Ni, Di Zhang, Shijie Zhen, Xiao Liang, Xiangjun Gong, Zujin Zhao, Dan Ding, Guangxue Feng,*, and Ben Zhong Tang. NIR light-driven pure organic Janus-like nanoparticles for thermophoresis-enhanced photothermal therapy. Biomaterials 2023, 301, 122261. (IF = 12.8)
22. Shengming Gan, Wenbo Wu, Guangxue Feng,* Zhiming Wang,* Bin Liu,* and Ben Zhong Tang*. Size Optimization of Organic Nanoparticles with Aggregation-Induced Emission Characteristics for Improved ROS Generation and Photodynamic Cancer Cell Ablation. Small 2022, 18, 2202242. (IF = 13.0)
23. Zhong-Hong Zhu, Di Zhang, Jian Chen, Hua-Hong Zou, Zhiqiang Ni, Yutong Yang, Yating Hu,* Ruiyuan Liu,* Guangxue Feng,* and Ben Zhong Tang. A biocompatible pure organic porous nanocage for enhanced photodynamic therapy. Mater. Horiz. 2023, 10, 4868-4881. (IF = 12.2)
24. Yuewen Yu, Yubo Liu, Yitao Chen, Jinke Chen, Guangxue Feng* and Ben Zhong Tang*. Cationic AIE-active photosensitizers for highly efficient photodynamic eradication of drug-resistant bacteria. Mater. Chem. Front. 2023, 7, 96-105. (IF = 7.0)
25. Yuewen Yu, Hanyu Jia, Yubo Liu, Le Zhang, Guangxue Feng,* and Ben Zhong Tang* Recent Progress in Type I Aggregation-Induced Emission Photosensitizers for Photodynamic Therapy. Molecules 2023, 28, 332. (IF = 4.6)
26. Zhong-Hong, Zhu, Changjiang Bi, Hua-Hong Zou, Guangxue Feng,* Suping Xu,* and Ben Zhong Tang*, Smart Tetraphenylethene-Based Luminescent Metal–Organic Frameworks with Amide-Assisted Thermofluorochromics and Piezofluorochromics. Adv. Sci. 2022, 9, 2200850. (IF = 15.1)
27. Shanshan Liu, Bingnan Wang, Yuewen Yu, Yubo Liu, Zeyan Zhuang, Zujin Zhao, Guangxue Feng,* Anjun Qin,* and Ben Zhong Tang*. Cationization-Enhanced Type I and Type II ROS Generation for Photodynamic Treatment of Drug-Resistant Bacteria. ACS Nano 2022, 16, 9130-9141. (IF = 15.8)
28. Zhong-Hong Zhu, Yubo Liu, Chi Song, Yating Hu,* Guangxue Feng,* and Ben Zhong Tang, Porphyrin-Based Two-Dimensional Layered Metal–Organic Framework with Sono-/Photocatalytic Activity for Water Decontamination. ACS Nano 2022, 16, 1346-1357. (IF = 15.8)
29. Yuewen Yu, Shuang Wu, Le Zhang, Shidang Xu, Chunhui Dai, Shengming Gan, Ganfeng Xie,* Guangxue Feng,* and Ben Zhong Tang, Cationization to boost both type I and type II ROS generation for photodynamic therapy. Biomaterials 2022, 280, 121255. (IF = 12.8)
30. Xin Zhou, Deping Wang, Zhiyuan Gao, Mingyue He, Jiayi Hou, Hui Zhang,* Guangqiang Zhang,* Dan Ding, Guangxue Feng,* Highly sensitive light-up near-infrared fluorescent probe for detection and imaging of β-glucuronidase in human serum, living cells and tumor-bearing mice. Sci. China Mater. 2022, 65, 836-844. (IF = 6.8)
31. Zhong-Hong Zhu, Zhiqiang Ni, Hua-Hong Zou, Guangxue Feng,* and Ben Zhong Tang,* Smart Metal Organic-Framework with Reversible Luminescence/Magnetic Switch Behavior for HCl Vapor Detection. Adv. Funct. Mater. 2021, 31, 2106925. (IF = 18.5)
32. Sheng Zeng, Heqi Gao, Chuang Li, Shaoqing Xing, Zhaoliang Xu, Qian Liu,* Guangxue Feng,* and Dan Ding,* Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle-Invasive Bladder Cancer. Adv. Healthcare. Mater. 2021, 10, 2101063. (IF = 10.0)
33. Shanshan Liu, Guangxue Feng,* B. Z. Tang,* and B. Liu,* Recent Advances of AIE Light-Up Probes for Photodynamic Therapy. Chem. Sci. 2021, 12, 6488-6506. (IF = 7.6)
34. Guangxue Feng, Guoqiang Zhang, Dan Ding,* Design of superior phototheranostic agents by Jablonski diagram. Chem. Soc. Rev. 2020, 49, 8179. (IF = 40.4)