关于举办华南理工大学“海内外优秀青年学者论坛”生物医学科学与工程学院分论坛的通知

发布者:郑亚萍发布时间:2019-06-04浏览次数:245



广大师生:


华南理工大学“海内外优秀青年学者论坛”于201511月首次启动,旨在面向全球邀请拥有不同学术背景的青年才俊,围绕国际科学前沿、热点研究领域以及行业产业的技术问题等展开探讨和交流。通过这个平台,互相启迪、开拓视野,增强国际交流与合作,促进双方共同发展。

一、论坛时间

201965

二、地点

华南理工大学大学城校区B12-318

三、论坛议程

日期

时间

事项或议程

65日(周三)上午

10:00-10:10

开幕式

学院领导致欢迎词

10:10-11:10

学术报告

主持人:王均

题目:Role and mechanism of SLAM family receptors in NKT cell development

报告人:鲁岩博士,加拿大蒙特利尔临床研究所

欢迎广大师生参加!

  广东省生物医学工程重点实验室

                                            2019520

  


附:

1. Role and mechanism of SLAM family receptors in NKT cell development(鲁岩博士)

内容摘要:

Invariant natural killer T cells (iNKT cells) develop through an incompletely understood process that requires positive selection by CD4+CD8+ double-positive thymocytes and SLAM family receptors (SFRs).  Here we found that SFRs promoted the development of iNKT cells by reducing the strength of the T cell antigen receptor (TCR) signal after positive selection.  This effect improved the survival of iNKT cells and their responses to antigen.  Loss of SFRs upregulated the expression of inhibitory receptors, including PD-1, on iNKT cells to mitigate the deleterious effect of SFR deficiency.  The role of SFRs could be mimicked by expression of SLAMF6 alone in SFR-deficient mice, and this involved the adaptor SAP–kinase Fyn complex and the phosphatase SHP-1. Thus, SFRs foster iNKT cell development by attenuating TCR signal strength after positive selection.

报告人简介:

鲁岩于20146月获得南京农业大学博士学位;20148月赴加拿大蒙特利尔临床研究所分子肿瘤学实验室进行博士后研究。近年来,他已在Nature ImmunologyNatureJournal of Experimental Medicine等国际权威杂志发表学术论文13篇。主要研究方向是固有类T细胞发育和功能的分子调控机制。