Title: Revitalizing exhausted T Cells with IL-10: a journey from lab discovery to clinical application for enhanced cancer immunotherapy

Speaker: Dr. Li Tang,Associate Professor

Time: Apeil 26，2024，10:00a.m-11:30 a.m

Venue: C1-b115, Guangzhou International Campus

[Abstract]

Our immune system interacts with many diseases ina multidimensional manner involving substantial biological, chemical, andphysical exchanges. Manipulating the disease-immunity interactions may affordnovel immunotherapies to better treat diseases such as cancer. My lab aims todevelop novel strategies to engineer the multidimensional immunity-diseaseinteractions (or termed ‘immunoengineering’) to create safe and effectivetherapies against cancer. We leverage the power of metabolic and cellular bioengineering,synthetic chemistry and material engineering, and mechanical engineering toachieve controllable modulation of immune responses. In this talk, Iwill share our recent discovery of IL-10 as ametabolic reprogramming agent that reinvigorates the terminally exhausted CD8+tumor infiltrating lymphocytes. This strategy has been extended to developmetabolically armored CAR-T cells with IL-10 secretion to counter exhaustion-associateddysfunction in the tumor microenvironment for enhanced anticancer immunity.This new CAR-T cell therapy, i.e. IL-10-secreting CAR-T, has shown promise inseveral on-going IIT clinical trials (ClinicalTrials.gov ID: NCT05715606, NCT05747157,NCT06120166) in the treatment of refractory/relapsed CD19+ B cellleukemia and lymphoma.