杨显珠教授

国家级青年人才项目入选者

电子邮件:

yangxz@scut.edu.cn

办公地址：

广州国际校区C1-c906

实验室网站链接：https://www2.scut.edu.cn/nanomedicine/yjtdcy/list.htm

2017-至今 华南理工大学 教授

2013-2017 合肥工业大学 教授

2012-2012 中国科学技术大学生命科学学院 博士后

2006-2011 中国科学技术大学 博士

2002-2006 合肥工业大学 学士

生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、药学（专硕）

生物医用材料、纳米医学、药剂学

主要从事高分子药物载体，特别是核酸药物载体方面的研究，以通讯作者在Nature Nanotechnology、Nature Communications、Advanced Materials、National Science Review、Advanced Functional Materials、ACS Nano、Nano Letters等发表论文70多篇，论文被引用1万余次；主持基金委联合基金重点项目、优秀青年基金、面上项目、广东省杰出青年基金等，参与863计划、国家重点研发计划、广东省“珠江人才计划”创新团队等项目。获2019年中国生物材料学会科学技术奖二等奖、2020年安徽省科学技术奖二等奖、2021年度广东省自然科学奖一等奖。

代表性论文  

1.Xiaowan Huang#, Ziyang Cao#,Jieying Qian#, Tao Ding, Yanxia Wu, Hao Zhang, Suqin Zhong, XiaoliWang, Xiaoguang Ren, Wang Zhang, Youcui Xu, Guangyu Yao, Xingwu Wang, XianzhuYang*, Long-ping Wen*, Yunjiao Zhang*, Nanoreceptors promote mutant p53protein degradation by mimicking selective autophagy receptors, NatureNanotechnology 2024, doi:10.1038/s41565-023-01562-5.

2.Yuxi Zhang#, Chaoran Chen#,Miao Su, Junxia Wang*, Cheng Li*, XianzhuYang*, Hydrophobization of Ribonucleic Acids for Facile Systemic Deliveryand Multifaceted Cancer Immunotherapy, Nano Letters, 2024, 24, 4, 1376-1384

3.Yi Zhang#, Mingjie Wang#,Ling Ye#, Shengqi Shen, Yuxi Zhang, Xiaoyu Qian, Tong Zhang, MengqiuYuan, Zijian Ye, Jin Cai, Xiang Meng, Shiqiao Qiu, Shengzhi Liu, Rui Liu,Weidong Jia, Xianzhu Yang*, HuafengZhang*, Xiuying Zhong*, Ping Gao*, HKDC1 promotes tumor immune evasion inhepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1expression, Nature Communications, 2024, 15, 1314

4.Yueqiang Zhu#, Liangjie Jin#,Junbin Chen, Miao Su, Tianmeng Sun, Xianzhu Yang*, Promoting the recruitment, engagement, and reinvigorationof effector T cells via an injectable hydrogel with a supramolecular bindingcapability for cancer immunotherapy Advanced Materials, 2023, 35, 2309667.

5.Xu Dai#, Yueqiang Zhu#, MiaoSu, Junbin Chen, Song Shen, Cong-Fei Xu, Xianzhu Yang*, Rigid shelldecorated nanodevice with Fe/H2O2 supply and glutathionedepletion capabilities for potentiated ferroptosis and synergizedimmunotherapy, Advanced FunctionalMaterials, 2023,33, 202215022.

6.Wenxuan Xu#, Dongdong Li#,Chaoran Chen#, Junxia Wang*, Xinhua Wei*, Xianzhu Yang*, Design of mitoxantrone-loaded biomimetic nanocarrier withsequential photothermal/photodynamic/chemotherapy effect for synergizedimmunotherapy, Advanced Functional Materials, 2023, 33, 2302231.

7.Shan He, Chaoran Chen, Fangzheng Li, Wenxuan Xu,Dongdong Li,* Ming Liang,* Xianzhu Yang*,Polymeric Nanosponge as Broad-Spectrum Reactive Oxygen Species Scavenger forAcute Kidney Injury Treatment, Nano Letters, 2023, 23, 19,8978–8987

8.Ziyang Cao, Dongdong Li, Liang Zhao, Mengting Liu,Pengyue Ma, Yingli Luo, Xianzhu Yang*，Bioorthogonal in situ assembly of nanomedicines asdrug depots for extracellular drug delivery, Nature Communications2022, 13, 2038.

9.Liang Zhao,Dongdong Li, Yuxi Zhang, Qiaoyi Huang,Zhenghai Zhang, Chaoran Chen, Cong-Fei Xu, Xiao Chu, Yu Zhang, XianzhuYang*, HSP70 Promoter-Driven CRISPR/Cas9 System Activated by ROS forMultifaceted Anticancer Immune Response and Potentiated Immunotherapy, ACSNano, 2022, 16, 13821−13833.

10.LiangjieJin#, Dongmei Yang#, Yonghong Song#, DongdongLi* Weijia Xu Yueqiang Zhu, Cong-Fei Xu, Yang Lu*, Xianzhu Yang*, InSitu Programming of Nanovaccines for Lymph Node-targeted Delivery and CancerImmunotherapy, ACS Nano 2022, 16, 15226−15236.