王均教授

办公电话:

020-39380975

电子邮件:

mcjwang@scut.edu.cn

办公地址：广州国际校区C1-c808

国际生物材料科学与工程会士

英国皇家化学会会士

2018-至今，华南理工大学生物医学科学与工程学院，院长，教授

2018-至今，国家人体组织功能重建工程技术研究中心，副主任

2019-至今，广东省生物医学工程重点实验室，主任

2018-2021，华南理工大学医疗器械研究检验中心，主任

2016-2020，华南理工大学生命科学研究院，教授

2006-2016，中国科学技术大学生命科学学院，教授；合肥微尺度物质科学国家实验室（筹），研究员

2004-2006，中国科学技术大学高分子科学与工程系，教授

2002-2004，约翰霍普金斯大学医学院生物医学工程系，博士后

1999-2002，Johns Hopkins Singapore，博士后

1993-1998，武汉大学，博士，高分子化学与物理专业

1989-1993，武汉大学，学士，主修化学专业，辅修细胞生物学专业

生物医学工程、材料科学与工程、生物学、药学

纳米生物医学，纳米药物和生物材料，肿瘤免疫治疗，mRNA疫苗，肿瘤干细胞和靶向治疗

在医用生物材料合成、纳米药物递送及疾病治疗研究方面取得了系列创新性成果，在Sci Transl Med、Nat Commun、PNAS、JACS、Angew Chem Int Ed、Adv Mater等发表论文200余篇，引用19000余次，申请、授权发明专利30余项，获国家自然科学奖二等奖及省部级科技奖励4项，获国家重点研发计划、973计划、国家自然科学基金重点项目等资助。

代表性论文列表：

1. Cheng-Tao Jiang^#, Kai-Ge Chen^#, An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen*, Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang*, Immunomodulating Nano-adaptors Potentiate Antibody-based Cancer Immunotherapy, Nature Communications, 2021, 12, 1359.

2. Cong-Fei Xu^#, Zi-Dong Lu^#, Ying-Li Luo, Yang Liu, Zhi-Ting Cao, Song Shen, Hong-Jun Li, Jing Liu, Kai-Ge Chen, Zhi-Yao Chen, Xian-Zhu Yang, Zhen Gu, Jun Wang*, Targeting of NLRP3 Inflammasome with Gene Editing for the Amelioration of Inflammatory Diseases, Nature Communications, 2018, 9, 4092.

3. Yan-Dan Yao^#, Tian-Meng Sun^#, Song-Yin Huang, Shuang Dou, Ling Lin, Jia-Ning Chen, Jian-Bin Ruan, Cheng-Qiong Mao, Feng-Yan Yu, Mu-Sheng Zeng, Jian-Ye Zang, Qiang Liu, Feng-Xi Su, Peter Zhang, Judy Lieberman*, Jun Wang*, Erwei Song*, Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2⁺ Breast Cancer Growth and Metastasis, Science Translational Medicine, 2012, 4, 130ra48.

4. Hong-Jun Li#, Jin-Zhi Du#, Xiao-Jiao Du#, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-Hua Zhu, Shu-Ming Nie*, Jun Wang*, Stimuli-responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy, PNAS, 2016, 113, 4164-4169.

5. Jin-Zhi Du*, Hong-Jun Li, Jun Wang*, Tumor-Acidity Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles to Overcome Delivery Barriers in Cancer Nanomedicine, Accounts of Chemical Research, 2018, 51, 2848-2856.

6. Senbiao Chen^#, Dongdong Li^#, Xiaojiao Du,* Xinyu He, Mengwen Huang, Yang Wang, Xianzhu Yang*, Jun Wang*, Carrier-free Nanoassembly of Doxorubicin Prodrug and siRNA for Combinationally Inducing Immunogenic Cell Death and Reversing Immunosuppression, Nano Today, 2020, 35, 100924.

7. Zhi-Ting Cao, Li-Qin Gan, Wei Jiang, Ji-Long Wang, Hou-Bing Zhang, Yue Zhang, Yucai Wang, Xianzhu Yang, Menghua Xiong*, Jun Wang*, Protein Binding Affinity of Polymeric Nanoparticles as a Direct Indicator of Their Pharmacokinetics, ACS Nano, 2020, 14, 3563-3575.

8. Hua Huang, Cheng-Tao Jiang, Song Shen*, An Liu, Yun-Jiu Gan, Qi-Song Tong, Sen-Biao Chen, Zhu-Xin Gao, Jin-Zhi Du, Jie Cao*, Jun Wang*, Nanoenabled Reversal of IDO1-Mediated Immunosuppression Synergizes with Immunogenic Chemotherapy for Improved Cancer Therapy, Nano Letters, 2019, 19, 5356-5365.

9. Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, Youyong Yuan*, Jun Wang*, A General Strategy for Macrotheranostic Prodrug Activation: Synergy by Tumor Acidic Microenvironment and Bioorthogonal Chemistry, Angewandte Chemie International Edition, 2020, 59, 7168-7172

10. Cong-Fei Xu, Shoaib Iqbal, Song Shen, Ying-Li Luo, Xianzhu Yang*, Jun Wang*, Development of “CLAN” Nanomedicine for Nucleic Acid Therapeutics, Small, 2019, 1900055.

    论文详细列表：http://www.researcherid.com/rid/F-9033-2011