Publication

Bian Lab website has moved to Bian Lab (x-mol.com)

Journal publications

(*corresponding author, +equal contribution)

  1. +Yao, Z.; +Yuan, W.; Xu, J.; Tong, W.; Mi, J.; Chow, D.H.K; Li, Y.; Yao, H.; Li, X.; Xu, S.; Guo, J.; Zhu, Q.; Ho, P.C.; *Bian, L.; *Qin, L. Magnesium-encapsulated injectable hydrogel and 3D-engineered polycaprolactone conduit facilitate peripheral nerve regeneration. Advanced Science, 2022.

  2. Deng, Y.; Li, R.; Wang, H.; Yang, B.; Shi, P.; Zhang, Y.; *Yang, Q.; *Li, G.; *Bian, L. Biomaterial-mediated presentation of jagged-1 mimetic ligand enhances cellular activation of notch signaling and bone regeneration. ACS Nano, 2022, 16, 1, 1051–1062.

  3. Oh, J.; Xia, X.; Wong, W.K.R.; Wong, S.H.D.; Yuan, W.; Wang, H.; Lai, C.H.N.; Tian, Y.; Zhang, H.; Zhang, Y.; Li, G.; *Lin,Y.; * Bian, L. The effect of the nanoparticle shape on T cell activation. Small, 2022, smll.202107373.

  4. +Xia, X.; +Xu, X.; Xie, X.; Lai, H.; Xue, J.; Zhang, W.; Rai, A.; Li, Z.; Peng, X.; Zhao, P.; *Bian, L.; *Chiu, P.W.R. Adhesive hemostatic hydrogel with ultrafast gelation arrests acute upper gastrointestinal hemorrhage in pigs. Advanced Functional Materials, 2021.

  5. +Deng, Y.; +Zhang, X.; +Li, R.; Li, Z.; Yang, B.; Shi, P., Zhang, H.; Wang, C.; Wen, C.; *Li, G., *Bian, L. Biomaterial-mediated presentation of wnt5a mimetic ligands enhances chondrogenesis and metabolism of stem cells by activating non-canonical Wnt signaling. Biomaterials, 2022, 281, 121316.

  6. +Zhao, P.; +Xia, X.; +Xu, X.; Leung, K.K.C.; Rai, A.; Deng, Y., Yang, B.; Lai, H.; Peng, X.; Shi, P.; Zhang, H.; *Chiu, P.W.R.; *Bian, L. Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy. Nature Communications, 2021, 12, Article number: 7162. 

  7. +Li, Z.; +Wang, H.; +Zhang, K.; Yang, B.; Xie, X.; Yang, Z.; Kong, L.; Shi, P.; Zhang, Y.; Ho, Y.P.; *Zhang, Z.; *Li, G.; *Bian, L. Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration. Bioactive Materials, 2022, Vol. 13, 9-22.

  8. +Yuan, X.; +Yuan, W.; Ding, L.; Shi, M.; Luo, L.; Wan, Y.; Oh, J.; *Zhou, Y.; *Bian, L.; *Deng, Y.B. Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation. Biomaterials, 2021, 279, 121190.

  9. +Zhang, J.; +Wong, S.H.D.; Wu, X.; Lei, H.; Qin, M.; Shi, P.; *Wang, W.; *Bian, L.; *Cao, Y. Engineering photoresponsive ligand tethers for mechanical regulation of stem cells. Advanced Materials, 2021, 2105765.

  10. +Zhang, K.; +Feng, Q.; Fang, Z.; *Gu, L.; *Bian, L. Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics. Chemical Reviews, 2021, 22;121(18):11149-11193.

  11. +Peng, X.; +Xia, X., +Xu, X.; Yang, X.; Yang, B.; Zhao, P.; Yuan, W.; *Chiu, P.W.R.; *Bian, L. Ultra-fast self-gelling powder mediate robust wet adhesion to promote healing of gastrointestinal perforations. Science Advances, 2021, Vol. 7, no. 23, eabe8739

  12. +Yuan, W.; +Wang, H.; +Fang, C.; Yang, Y.; Xia, X.; Yang, B.; *Lin, Y.; *Li, G.; *Bian, L. Microscopic local stiffening in supramolecular hydrogel network expedites stem cell mechanosensing in 3D and bone regeneration. Materials Horizons, 2021, 8, 1722-1734.

  13. +Peng, X.; +Xu, X.; Deng, Y.; Xie, X.; Xu, L.; Xu, X.; Yuan, W.; Yang, B.; Yang, X.; *Xia, X.; *Li Duan, L.; *Bian, L.Ultrafast self-gelling and wet adhesive powder for acute hemostasis and wound healing. Advanced Functional Materials, 2021.

  14. +Yang, B.; +Wei, K.; Loebel, C.; Zhang, K.; Feng, Q.; Li, R.; Wong, D.S.H.; Xu, X.; Lau, C.; Chen, X.; Zhao, P.; Yin, C.; Burdick, J.A.; *Wang, Y.; *Bian, L. Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics. Nature Communications, 2021, Article number: 3514.

  15. +Wong, S.H.D.; +Xu, X.; Chen, X., Xing, Y.; Xu, L.; Lai, N.C.H.; Oh, J.; Wong, R.W.K.; Wang, X.; Han, S.; You, W., Shuai, X.; Wong, N., *Tan, Y.; *Duan, L.; *Bian, L. Manipulation of the nanoscale presentation of integrin ligand produces cancer cells with enhanced stemness and tumorigenicity. Nano Letters, 2021, 21, 7, 3225–3236.

  16. Rui Li, R.; Li Y.; Mu, M.; Yang, B.; Chen, X.; Lee, W.Y.W.; Ke, Y.; *Yung W.H.; *Tang B. Z.; *Bian, L. Multifunctional nanoprobe for the delivery of therapeutic siRNA and real time molecular imaging of Parkinson’s disease biomarkers. ACS Appl. Mater. Interfaces, 2021, 13, 10, 11609–11620.

  17. +Zhao, P.; +Yang, B.; Xu, X.; Lai, N.C.H.; Li, R.; Yang, X.; *Bian, L. Nanoparticle-assembled vacuolated coacervates control macromolecule spatiotemporal distribution to provide a stable segregated cell microenvironment. Advanced Materials, 2021, 33, 9, 2007209.

  18. Zhu, M.; Zhang, K., Feng, L.; Lin, S.; Pan, Q.; *Bian, L.; *Li, Gang. Surface decoration of development-inspired synthetic N-Cadherin motif via Ac-BP promotes osseointegration of metal implants. Bioactive Materials, 2021, 6, 5, 1353-1364

  19. +Xu, X.; +Xia, X.; +Zhang, K.; Rai, A.; Li, Z.; Zhao, P.; Wei, K.; Zou, L.; Yang, B.; Wong, W.K.R., *Chiu, W.Y.P.; *Bian, L. Bioadhesive hydrogels demonstrating pH-independent and ultrafast gelation promote gastric ulcer healing in pigs. Science Translational Medicine, 2020, 12, 558, eaba8014.

  20. +Yuan, W.; +Li, Z.; +Xie, X.; Zhang, Z; *Bian, L. Bisphosphonate-based nanocomposite hydrogels for biomedical applications. Bioactive Materials, 2020, 5, 4, 819-831.

  21. Wen, G.;  Li, X.; Zhang, Y.; Han, X.; Xu, X.; Liu, C.; Chan, W.Y.K; Lee, C.S.; *Yin, C.; *Bian, L.; *Wang, L. Effective phototheranostics of brain tumor assisted by near-infrared-II light-responsive semiconducting polymer nanoparticles. ACS Appl. Mater. Interfaces, 2020, 12, 30, 33492–33499.

  22. Zhao, P.; Yin, C.; Zhang, Y.; Chen, X.; Yang, B.; Xia, J.; *Bian, L. Mussel cuticle-mimetic ultra-tough and self-healing elastomers with double-locked nanodomains exhibit fast stimuli-responsive shape transformation. Journal of Materials Chemistry A, 2020, 8, 12463-12471.

  23. Wong, S.H.D.; Wong, W.K.R.; Lai, N.C.H.; Oh, J.; Li, Z.; Chen, X.; Yuan, W.; *Bian, L. Soft polymeric matrix as a macroscopic cage for magnetically modulating reversible nanoscale ligand presentation. Nano Letters, 2020, 20, 5, 3207-3216.

  24. +Chen, X.; +Lai, N.C.H.; +Wei, K.; Li, R.; Cui, M.; Yang, B.; Wong, S.H.D.; Deng, Y.; Li, J.; Shuai, X.; *Bian, L. Biomimetic presentation of cryptic ligands via single-chain nanogels for synergistic regulation of stem cells. ACS Nano,  2020, 14, 4, 4027-4035.

  25. Yang, X.; Jiang, X.; Yang, H.; *Bian, L.; *Chang, C.; *Zhang, L. Biocompatible cellulose-based supramolecular nanoparticles driven by host–guest interactions for drug delivery. Carbohydrate Polymers, Volume 237, 1 June 2020, 116114.

  26. +Yin, C.;  +Li, X.; +Wen, G.; Yang, B.; Zhang, Y.; Chen, X.; Yang, X.; Zhao, P.; Li, S.; Li, R.; *Wang, L.; *Lee, C.S.; *Bian, L. Organic Semiconducting polymer amphiphile for near-Infrared-II light triggered phototheranostics. Biomaterials, 2019, 2020, 232: 119684.

  27. Yin, B.; et al.; *Bian, L.; *Tian, X.Y.; *Chan, M.N.; *Choi, C.H. Intrapulmonary cellular-level distribution of inhaled nanoparticles with defined functional groups and its correlations with protein corona and inflammatory response. ACS Nano, 2019, 13(12):14048-14069.

  28. Li, R; Lin, S., Zhu, M., Deng, Y., Chen, X., Wei, K., Xu, J., Li, G.; *Bian, L. Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration. Science Advances, 2019, 5: eaaw3896.

  29. Zhou, H.; Liang, C.; Wei, Z.; Bai, Y.; Bhaduri, S.B; Webster, T. J.; *Bian, L.; *Yang, L. Injectable biomaterials for translational medicine. Materials Today,  2019, 28: 81.

  30. Chen, X.; Li, R; Wong, S.H.D.; Wei, K.; et al.; Xia, J.; Chen, G.; Li, G.; *Bian, L. Conformational manipulation of scale-up prepared single chain polymeric nanogels for multiscale regulation of cells. Nature Communications, 2019, volume 10, Article number: 2075.

  31. +Xu, J.; +Feng, Q.; +Lin, S.; Yuan, W.; Li, R.; Li, J.; Wei, K.; Chen, X.; Zhang, K.; Yang, Y.; Wu, T.; Wang, B.; Zhu, M.; Guo, R.; *Li, G.; *Bian, L. Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules. Biomaterials, 2019; 210:51-61.

  32. Wei, K.; Chen, X.; Zhao, P.; Feng, Q.; Yang, B.; Li, R.; *Zhang Z.; *Bian, L. Stretchable and bio-adhesive supramolecular hydrogels activated by a one-stone-two-bird post-gelation functionalization method. ACS Appl. Mater. Interfaces, 2019, 11 (18), pp 16328–16335.

  33. +Kang, H.; +Yang, B.; Zhang, K.; Pan, Q.; Yuan, W.; Li, G.; *Bian, L. Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination. Nature Communications,  2019, volume 10, Article number: 1696 .

  34. +Zhang, K.; +Yuan, W.; Wei, K.; Yang, B.; Chen, X.; Li, Z.; *Zhang, Z.; *Bian, L. Highly dynamic nanocomposite hydrogels self-assembled by metal ion-ligand coordination, Small, 2019, smll.201900242.

  35. +Feng, Q.; +Xu, J.; Zhang, K.; Yao, H.; Zheng, N.; Zheng, L.; Wang, J.; Wei, K.; Xiao, X.; *Qin, L; *Bian, L. Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects. ACS Central Science, 2019, 5 (3), pp 440–450.

  36. +Kang, H.; +Wong, S.H.D.; Pan, Q..; Li, G.; *Bian, L. Anisotropic ligand nanogeometry modulates the adhesion and polarization state of macrophages. Nano Letters, 2019 Mar 13;19(3):1963-1975.

  37. +Wong, S.H.D.; +Yin, B.; Lin S.; Yang, B.; Li, R.; Feng, F.; Yang, H.; Zhang, L.; Yang, Z.; Li, G.; *Choi, C. H.; *Bian, L. Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing-dependent differentiation of stem cells. Advanced Functional Materials, Volume 29, Issue 8, 2019, adfm.201806822.  

  38. +Kang, H.; +Zhang, K.; Jung, H.J.; Yang, B.; Chen, X.; Pan, Q.; Li, R.; Xu, X.; Li, G.; Dravid, V.; *Bian, L. In situ reversible heterodimeric nanoswitch controlled by metal ion-ligand coordination regulates the adhesion, release, and differentiation of stem cells. Advanced Materials, 2018 Nov; 30(44), adma.201803591.

  39. +Yin, C.; +Wen, G.; Liu, C.; Yang, B.; Lin, S.; Huang, J.; Zhao, P.; Wong, S.H.D., Zhang, K.; Chen, X.; Li, G.; Jiang, X.; *Pu, K.; *Wang, L.; *Bian, L. Organic semiconducting polymer nanoparticles for photoacoustic labelling and tracking of stem cells in the second near-infrared window. ACS Nano, 2018, 12 (12), pp 12201–2211.

  40. +Zhang, K.; +Jia, Z.; Yang, B.; Feng, Q.; Xu, X.; Yuan, W.; Li, X.; Chen, X.; Duan, L.; *Wang, D.; *Bian, L. Adaptable hydrogels mediate cofactor-assisted activation of biomarker-responsive drug delivery via positive feedback for enhanced tissue regeneration. Advanced Science, 2018 Dec; 5(12): 1800875.

  41. +Kang, H.; +Zhang, K.; Pan, Q.; Lin, S.; Wong, S.H.D.; Li, J.; Lee, Y. W.; Yang, B.; Han, F.; *Li, B.; *Bian, L. Remote control of intracellular calcium using upconversion nanotransducers regulates stem cell differentiation in vivo. Advanced Functional Materials, 2018, adfm.201802642.  

  42. Li, J.; Lee, Y. W.; Wu, T.; Leung, Y.T.C; Xu, J.; Wong, S.H.D.; Li, R.; *Li, G.; *Tang, B.Z.; *Bian, L. Detection of matrix metallopeptidase 13 for monitoring stem cell differentiation and early diagnosis of osteoarthritis by fluorescent light-Up probes with aggregation-induced emission characteristics. Advanced Biosystems, 2018, 2 (10), adbi.201800010.

  43. +Chen, X.; +Dong, C.; +Wei, K.; +Yao, Y.; et al., Feng, Q.; Zhang, K.; Mak, A.; *Bian, L. Supramolecular hydrogels cross-linked by preassembled host-guest PEG cross-linkers resists excessive, ultrafast, and non-resting cyclic compression. NPG Asia Mater. 10, 788–799 (2018)   

  44. +Kang, H.; Jung, H.J.; Kim, S.K.; Wong, S.H.D.; Lin, S.; Li, G.; Dravid, V.; *Bian, L. Magnetic manipulation of reversible nanocaging controls in vivo adhesion and polarization of macrophages. ACS Nano, 2018 Jun 26;12(6):5978-5994.

  45. +Li, R.; +Li, J.; Xu, J.; Wong, S.H.D.; Chen, X.; Yuan, W.; *Bian, L. Multiscale reconstruction of a synthetic biomimetic micro-niche for enhancing and monitoring the differentiation of stem cells. Biomaterials, 2018,173:87–99.

  46. +Kang, H.; + Jung, H.J.; Wong, S.H.D.; Kim, S.K.; Lin, S.; Chan, K.F.; Zhang, L.; Li, G.; Dravid, V.; *Bian, L. Remote control of heterodimeric magnetic nanoswitch regulates the adhesion and differentiation of stem cells. J. Am. Chem. Soc., 2018;140 (18): 5909-5913.

  47. +Kang, H.; +Zhang, K.; Wong, S.H.D.; et al.; *Bian, L. Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization. Biomaterials, 2018,178:681-696.

  48. Zhu, M.; Wei, K.; Lin, S.; Wu, C.C.; *Li, G.; *Bian, L. Bio-adhesive polymersome for localized and sustained drug delivery at pathological sites with harsh enzymatic and fluidic environment via supramolecular host-guest complexation. Small, 2018 Feb;14(7), doi: 10.1002/smll.201702288.

  49. Chen, H.; Yan, X.; Feng, Q.; Zhao, P.; Xu, X. Ng, D. H.L.; *Bian, L. Citric acid/cysteine modified cellulose-based materials: green preparation and its applications in anti-counterfeiting, chemical Sensing, and UV shielding. ACS Sustain. Chem. Eng. 2017, 5 (12), 11387–11394.

  50. Zhao, P.; Wei, K.; Feng, Q.; Chen, H.; Wong, S.H.D.; Chen, X.; Wu, C.C.; *Bian, L. Mussel-mimetic hydrogels with defined cross-linkers achieved by controlled catechol dimerization exhibiting tough adhesion for wet biological tissues. Chemical Communications, 2017, 53, 12000-12003.  

  51. Feng, Q.; Wei, K.; Zhang, K.; Yang, B.; Tian, F.; Wang, G.; *Bian, L. One-pot solvent exchange preparation of non-swellable, thermoplastic, stretchable, and adhesive supramolecular hydrogels based on dual synergistic physical crosslinking. NPG Asia Mater.  2018, 10, e455.

  52. +Kang, H.; +Kim, M.; +Feng, Q.; Lin, S.; Wei, K.; Li, R.; Choi, C. J.; Kim, T.; Li, G.; *Oh, J. M.; *Bian, L. Nanolayered hybrid mediates synergistic co-delivery of ligand and ligation activator for inducing stem cell differentiation and tissue healing. Biomaterials, 2017, 149:12-28.

  53. +Zhang, K.; +Lin, S.; Feng, Q.; Dong, C.; Yang, Y.; *Li, G.; *Bian, L. Bioactive nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration. Acta Biomaterialia, 2017, 64:389-400.

  54. Wei, K.; Chen, X.; Li, R.; Feng, Q.; *Bian, L. Multivalent host-guest hydrogels as fatigue resistant 3D matrix for excessive mechanical stimulation of encapsulated cells. Chem. Mater. 2017, 29 (20), 8604-8610.

  55. +Kang, H.; +Kim, S.; Wong, S.H.D.; Jung, H.J.; Lin, Si.; Zou, K.; Li, R.; Li, G.; *Dravid, V.; *Bian, L. Remote manipulation of ligand nano-oscillations regulates adhesion and polarization of macrophages in vivo. Nano Letters, 2017, 17 (10), 6415-6427

  56. +Kang, H.; +Wong, S.H.D.; Yan, X.; Jung, H.J.; King, S.K.; Lin, Si.; Wei, K.; Li, G.; *Dravid, V.; *Bian, L. Remote control of multi-Modal nanoscale ligand oscillations regulates stem cell adhesion and differentiation. ACS Nano, 2017, 11 (10), 9636-9649.

  57. +Li, R.; +Xu, J.; Wong, S.H.D.; Li, J.; Zhao, P.; *Bian, L.; Self-assembled N-cadherin mimetic peptide hydrogels promote the chondrogenesis of mesenchymal stem cells through inhibition of canonical Wnt/β-catenin signaling. Biomaterials, 2017, 145: 33-43.

  58. +Ouyang, X.; +Zhang, K.; Wu, J.; Wong, S.H.D.; Feng, Q.; *Bian, L.; *Zhang, A. Optical ¦Ì-Printing of Cellular-Scale Microscaffold Arrays for 3D Cell Culture, Scientific Report, 2017 Aug 21;7(1):8880.

  59. Zhang, K.; Feng, Q.; Xu, J.; Xu, X.; Yeung, K.W.K.; *Bian, L. Self-assembled injectable nanocomposite hydrogels stabilized by bisphosphonate-magnesium (Mg2+) coordination regulates the differentiation of encapsulated stem cells via dual crosslinking. Advanced Functional Materials.2017, 27, 1701642.

  60. Li, J.; Yan, X.; Leung, Y.T.C; Wong, S.H.D.; Xu, J.; Li, R.; Zhao, Y.; Yung, Y.Y.C; Zhao, E.; *Tang, B.Z.; *Bian, L. Photo-controlled siRNA delivery and biomarker-triggered AIEgen emission by upconversion NaYF4:Yb3+Tm3+@SiO2 nanoparticles for inducing and monitoring stem cell differentiation. ACS Appl. Mater. Interfaces, 2017 Apr 5. doi: 10.1021/acsami.7b00845.

  61. +Wong, S.H.D.; +Li, J.; Yan, X.; Wang, B., Zhang, L.; *Bian, L. Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells. Nano Letters, 2017; 17 (3), 1685-1695

  62. +Feng, Q.; +Lin, S..; Zhang, K.; Dong, C.,  Sun, Y.; Huang, H.; Yan, X.; Zhang, L.; Li, G.; *Bian, L. Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy. Acta Biomaterialia, 2017 Apr 15;53:329-342

  63. +Xu, Y.; +Wei, K.; Zhao, P.; Feng, Q.; Choi, C.K. ; *Bian, L. Preserving the adhesion of catechol-conjugated hydrogels by thiourea-quinone coupling. Biomaterials Science, 2016, 4, 1726-1730.

  64. +Li, J.; +Lee, Y. W.; Wu, T.; Xu, J.; Zhang, K.; Wong, S.H.; Li, R.; *Li, G.; *Bian, L. Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles. Biomaterials, 2016 Dec; 110: 1-10

  65. Zhu, M.; Feng, Q.; Sun, Y.; Li, G.; *Bian, L. Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. J Biomed Mater Res B Appl Biomater. 2017 Nov;105(8):2292-2300. doi: 10.1002/jbm.b.33760

  66. +Feng, Q.; +Wei, K.; Lin, S.; Xu, Z.; Sun, Y.; Shi, P.; Li, G.; *Bian, L. Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. Biomaterials, 2016 Sept, 101: 217-28.

  67. Huang, H.; Xu, J.; Wei, K.; Xu, Y.; Choi, C. K; Zhu, M.; *Bian, L. Bioactive nanocomposite poly (ethylene glycol) hydrogels crosslinked by multifunctional layered double hydroxides nano-crosslinkers. Macromolecular Bioscience, 2016; 16 (7): 1019-26

  68. +Xu, J.; +Li, J.; Lin, S.; Wu, T.; Huang, H.; Zhang, K.; Su, Y.;  Yeung, K.W.K.; Li, G.; *Bian, L. Nanocarrier-mediated codelivery of small molecular drugs and siRNA to enhance chondrogenic differentiation and suppress hypertrophy of human mesenchymal stem cells. Advanced Functional Materials. 2016; 26 (15): 2463-72, adfm.201504070

  69. Wei, K.; Zhu, M.; Su, Y.; Xu, J.; Feng, Q.; Lin, S.; Wu, T.; Xu, J.; Tian, F.; Xia, J.; Li, G.; *Bian, L. Robust biopolymeric supramolecular “Host-Guest Macromer” hydrogels reinforced by in situ formed multivalent nanoclusters for cartilage regeneration. Macromolecules, 2016 Jan, 49 (3), pp 866–875.

  70. Li, J.; Lee, Y. W.; Wu, T.; Xu, J.; Zhang, K.; Li, G.; Xia, J.; *Bian, L. Multifunctional quantum dot nanoparticles for effective differentiation and long-term tracking of human mesenchymal stem cells in vitro and in vivo. Advanced Healthcare Materials, 2016 May;5(9):1049-57, adhm.201500879

  71. Zhu, M.; Lin, S.; Sun, Y.; Feng, Q.; Li, G.; *Bian, L. Hydrogels functionalized with N-cadherin mimetic peptide enhance osteogenesis of hMSCs by emulating the osteogenic niche. Biomaterials, 2016 Jan, Vol.77: 44–52

  72. Choi, C.K.; Xu, Y.; Wang, B.; Zhu, M.; Zhang, L.; *Bian, L. Substrate coupling strength of integrin-binding ligands modulates adhesion, spreading, and differentiation of Human mesenchymal stem cells. Nano Letters, 2015 Oct 14;15(10):6592-600.

  73. Choi, C.K.; Li, J.; Wei, K.; Xu, Y.; Ho, L.W.; Zhu, M.; To, K.W.; *Choi, C.H.; *Bian, L. A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells. J. Am. Chem. Soc.,  2015 Jun 17;137(23):7337-46.

  74. +Feng, Q.; +Zhu, M.; Wei, K.; *Bian, L. Cell-mediated degradation regulates human mesenchymal stem Cell chondrogenesis and hypertrophy in MMP-sensitive hyaluronic acid hydrogels. PLoS ONE, 2014 Jun 9;9(6)  

  75. +Zhu, M.; +Feng, Q.; *Bian, L. Differential effect of hypoxia on human mesenchymal stem cell chondrogenesis and hypertrophy in hyaluronic acid hydrogels.  Acta Biomaterialia 2014 Mar;10(3):1333-40.

  76. Bian, L.; Guvendiren, M.; Mauck, R.L.; Burdick, J.A.  Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc. Natl. Acad. Sci. USA  2013 Jun 18;110(25):10117-22. PMID: 23733927

  77. Bian, L.; Hou, C., Tous, E.; Rai R.; Mauck, R.L.; Burdick, J.A. The Influence of Hyaluronic Acid Hydrogel Crosslinking Density and Macromolecular Diffusivity on Human MSC Chondrogenesis and Hypertrophy. Biomaterials. 2013 Jan;34(2):413-21.

  78. Bian, L.; Zhai, D.Y.; Tous, E.; Rai R.; Mauck, R.L.; Burdick, J.A. Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials. 2011 Sep; 32(27):6425-34.

  79. Bian, L.; Zhai, D.Y.; Zhang, E.C.; Mauck, R.L.; Burdick, J.A. Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue Engineering Part A. 2012 Apr;18(7-8):715-24. PMID: 21988555

  80. Bian, L.; Zhai, D.Y.; Mauck, R.L.; Burdick, J.A. Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage. Tissue Engineering Part A. 2011 Apr; 17(7-8):1137-45.

  81. Bian, L., Stoker, A.M., Marberry, K.M, Ateshian, G.A., Cook, J.L., Hung, C.T. Effects of dexamethasone on the functional properties of cartilage explants during long term culture. Am J Sports Med. 2010 Jan; 38(1):78-85.

  82. Bian, L., Fong, J.V., Lima, E.G., Stoker, A.M., Ateshian, G.A., Cook, J.L., Hung, C.T. Dynamic mechanical loading enhances functional properties of tissue-engineered cartilage using mature canine chondrocytes. Tissue Engineering Part A. 2010 May;16(5):1781-90.

  83. Bian, L., Ng, K.W., Lima, E.G., Williams, D.Y., Ateshian, G.A., Hung, C.T. Influence of temporary chondroitinase ABC-induced GAG suppression on maturation of tissue engineered cartilage. Tissue Engineering Part A. 2009 Aug; 15(8):2065-72.

  84. Bian, L., Kaplun, M., Williams, D.Y., Ateshian, G.A., Hung, C.T. Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long term culture. Journal of Biomechanics 2009 Feb 9; 42(3):286-90. Epub 2008 Dec 30.

  85. Bian, L., Angione, S.L., Ng, K.W., Lima, E.G., Williams, D.Y., Mao D.Q., Ateshian, G.A., Hung, C.T. Influence of decreasing nutrient path length on the development of engineered cartilage. Osteoarthritis and Cartilage, 2009 May;17(5):677-85.

  86. Bian, L., Lima, E.G., Angione, S.L., Ng, K.W., Williams, D.Y., Xu, D., Stoker, A.M., Cook, J.L., Ateshian, G.A., Hung, C.T. Mechanical and biochemical characterization of cartilage explants in serum-free culture. Journal of Biomechanics, 2008, 41 (6): 1153-1159.

Patents

·      US patent (US 2010/0036492A1): osteochondral implants, arthroplasty methods, devices and systems. Inventors: Hung C.T, Ateshian, G.A, Lima, E.G., Cook, J.L., Bian, L.

·       US patent (US 9889086B2): Bioadhesive and injectable hydrogel. Inventors: Bian. L; Feng, Q.; Wei, K.; Lin, S.; Li, G. Patent date: Feb 13, 2018.

·       US patent (US10240190B2): Nano-constructs for polynucleotide delivery. Inventors: Bian L, Choi, C.H. Choi, C.K.; Patent date: March 26, 2019.

·       US/China patent (US10208104B2): Fast and efficient conjugation method based on thiourea-catechol coupling. Inventors: Bian, L.; Xu, Y.; Zhao, P.; Wei, K. Patent date: Feb 19, 2019.

·       US/China patent: Scalable and versatile method for preparing single-chain nanoparticles. Inventors: Chen, X..; Wei, K.; Bian, L.

·       US/China patent: Injectable hydrogels that promote mineralization and afford sustained release of bioactive ions. Inventors: Zhang, K.; Bian, L.

Book chapters

·       Biomedical Nanotechnology: Methods and Protocols, Second edition, Springer, 2016

·       Bio-Inspired Materials for Biomedical Engineering, Wiley, 2013