A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses

Xinpei Li,^1,2 Yuan Liu,^1,2 Xiaofeng He,^1,2 Dongrong He,^1,2 Kun Chen,^1,2,* and Panchao Yin ^1,2,*

Supra-particle assemblies are co-assembled by poly(4-vinylpyridine), 2.5 nm iron/molybdenum oxide clusters ({Mo₇₂Fe₃₀}) and antigens of Mycobacterium bovis to enhance the vaccine immune response in mice. {Mo₇₂Fe₃₀} and poly(4-vinylpyridine) together act as vaccine adjuvants that improve the magnitude and durability of antibody responses as well as the T cell-derived cytokine patterns, resulting in enhanced humoral and cellular immune response.

由聚（4-乙烯基吡啶）、2.5 nm 铁/钼氧化物簇 ({Mo₇₂Fe₃₀})和牛分枝杆菌的抗原共同组装形成Mb/{Mo₇₂Fe₃₀}@P4VP 的病毒状超粒子组装体，以增强小鼠的疫苗免疫反应。组装体中的 {Mo₇₂Fe₃₀} 和 P4VP作为疫苗佐剂，可提高抗体反应的强度、持久性以及 T 细胞衍生的细胞因子模式，从而增强体液和细胞免疫反应。这种共组装方法提供了对难治性分枝杆菌感染的保护，在疫苗递送中，为以低成本和大规模生产优化纳米粒子对抗原的负载方式开辟了新途径。

文章链接：https://link.springer.com/article/10.1007/s12274-021-4004-9