Jin-Zhi Du, Professor. He obtained his B.Sc. and Ph.D. degree at University of Science and Technology of China under the supervision of Prof Jun Wang. He then did his postdoctoral research at Emory University School of Medicine with Prof. Shuming Nie. He established his research group October 2016 at South China University of Technology (SCUT). The research interests of his lab involve the development of nanoparticles as tools for drug delivery and cancer immunotherapy. He has published over 40 papers in prestigious journals including Acc. Chem. Res., PNAS, JACS, Angew. Chem. Int. Ed., ACS Nano, Nano Lett.etc. These papers have received over 3500 citation, with the highest citation of one single paper around 600 times. His research has been funded by National Natural Science Foundation for Excellent Young Scholar, Guangdong Provincial Distinguished Young Scholar, and National key R & D program.
Phone: +86 20 39380967; E-mail: djzhi@scut.edu.cn
Education and Work Experience
2016/10-present Principal Investigator (PI), Professor Institutes for Life Sciences, South China University of Technnology
2012/05-2016/08 Postdoctoral Research Fellow Department of Biomedical Engineering, School of Medicine, Emory University Supervisor: Prof. Shuming Nie
2006/09-2011/12 Ph. D. in Polymer Chemistry and Biomaterials Department of Polymer Science & Engineering, and School of Life Sciences, University of Science and Technology of China Supervisor: Prof. Jun Wang
2002/09-2006/07 B.S. in Polymer Chemistry and Physics, Department of Polymer Science & Engineering, University of Science and Technology of China
Research interests
Biomaterials, Nanomedicine, Cancer Immunotherapy
Honors
2019, Second Prize, Science and Technology Prize of the Chinese Society for Biomaterials
2019, Excellent Young Scholar, National Natural Science Foundation
2019, Young Chang Jiang Scholars Program
2017, Guangdong Provincial Distinguished Young Scholar
Representative publications (#Co-first author, *Corresponding author)
1. Hong-Jun Li#, Jing Liu#, Ying-Li Luo, Sen-Biao Chen, Rong Liu, Jin-Zhi Du*, Jun Wang*, Intratumor performance and therapeutic efficacy of PAMAM dendrimers carried by clustered nanoparticles, Nano Lett. 2019, DOI: 10.1021/acs.nanolett.9b03913.
2. Jing Liu, Hong-Jun Li*, Ying-Li Luo, Cong-Fei Xu, Xiao-Jiao Du, Jin-Zhi Du*, Jun Wang Enhanced Primary Tumor Penetration Facilitates Nanoparticle Draining into Lymph Nodes after Systemic Injection for Tumor Metastasis Inhibition, ACS Nano 2019, 13, 8648-8658.
3. Song Shen#, Hong-Jun Li#, Kai-Ge Chen, Yu-Cai Wang, Xian-Zhu Yang, Zhe-Xiong Lian, Jin-Zhi Du*, Jun Wang*, Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy Nano Lett. 2017, 17, 3822–3829 (Top 20 most read articles in June 2017)
4. Hong-Jun Li#, Jin-Zhi Du*,#, Jing Liu, Xiao-Jiao Du, Song Shen, Yan-Hua Zhu, Xiaoyan Wang, Xiaodong Ye, Shuming Nie*, Jun Wang*, Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration ACS Nano 2016, 10, 6753–6761 (ESI highly cited paper, Top 20 most read articles in June 2016)
5. Hong-Jun Li#, Jin-Zhi Du#, Xiao-Jiao Du#, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-Hua Zhu, Shuming Nie*, Jun Wang*, Stimuli-Responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 4164–4169 (ESI highly cited paper)
6. Jinzhi Du, Lucas A. Lane, Shuming Nie*, Stimuli-Responsive Nanoparticles for Targeting the Tumor Microenvironment J. Controlled Release 2015, 219, 205–214
7. Chun-Yang Sun#, Yang Liu#, Jin-Zhi Du#, Zhi-Ting Cao, Cong-Fei Xu, Jun Wang*, Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery Angew. Chem. Int. Ed., 2016, 55, 1010–1014 (ESI highly cited paper)
8. Jin-Zhi Du, Xiao-Jiao Du, Cheng-Qiong Mao, Jun Wang*, Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anti-Cancer Drug Delivery J. Am. Chem. Soc.2011, 133, 17560–17563 (ESI highly cited paper)
9. Jin-Zhi Du, Tian-Meng Sun, Wen-Jing Song, Juan Wu, Jun Wang*, A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery Angew. Chem. Int. Ed. 2010, 49, 3621–3626 (ESI highly cited paper)
10. Jin-Zhi Du, Cheng-Qiong Mao, You-Yong Yuan, Xian-Zhu Yang, Jun Wang*, Tumor Extracellular Acidity-activated Nanoparticles as Drug Delivery Systems for Enhanced Cancer Therapy Biotech. Adv. 2014, 32, 789–803