Recently, Professor Wang Jun and Du Jinzhi, Professor of Biomedical Sciences and Engineering, Academy of Life Sciences, Medical College of South China University of Technology, were invited to publish Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA):A Powerful Tool for Designing Smar T Nanoparticles To Overcome Delivery Barriers in Cancer Nanomedicine (DOI: 10.1021/acs. accounts. 8b00195) reviews the research progress of the research team from the concept of acidity-sensitive nanodrug design to the construction of carrier materials to overcome the barrier of drug delivery in vivo and improve the therapeutic effect of cancer. South China University of Science and Technology is the only place to sign papers. Professor Wang Jun and Professor Du Jinzhi are the correspondent authors.
Nano-drug delivery system is one of the key research directions of Professor Wang Jun's research team. As a drug delivery system, nanoparticles can enhance the effect of drug treatment and improve the drug-forming ability of candidate drugs. However, after intravenous injection of nano-antineoplastic drugs, they need to undergo different barriers of drug delivery with different properties and characteristics, including blood circulation, vascular exudation, tumor tissue enrichment and infiltration, intracellular endocytosis and drug release. These physiological barriers severely reduce the efficiency of nano-drugs entering tumors and cancer cells, and reduce the anti-tumor effect. In response to the above problems, Professor Wang Jun's research team has made unremitting efforts for nearly ten years, and put forward the design concept of tumor acidity-sensitive nanocarriers. A series of tumor acidity-responsive nanocarriers based on 2,3-dimethylmaleamide and its derivatives have been constructed. They have biological inertia under normal physiological conditions, which can prolong the blood circulation of nanoparticles and increase swelling. Tumor enrichment, while specific performance changes occur in the tumor site, such as charge reversal, size change, PEG shelling, weight matching activation, effectively overcome the physiological barrier of drug delivery, improve drug delivery efficiency and cancer treatment effect. Research results published a series of high-level papers, such as Angew. Chem. Int. Ed. 2010, 49, 3621; J. Am. Chem. Soc. 2011, 133, 17560; ACS Nano 2012, 6, 771; Adv. Mater. 2012, 24, 5476; Adv. Mater. 2014, 26, 931; J. Am. Chem. Soc. 2015, 137, 15217, 15217; Proc. Natl. Acad. Acad. Aci. U. U. U. S. S. A. 2016, 113, 4164; AngAngAngAng. Chem. Chem. Chem. Soc. Soc. Soc. 2011, 2016, 2016; AngAngAngAngAngAngAngAngAng. CheCheChem. 128, 1010, etc. The proposed research strategy has been widely concerned and adopted by domestic and foreign peers. The above series of papers have been cited nearly 2000 times, of which 5 papers have been listed in the ESI high cited list.
Full text links：https://pubs.acs.org/doi/10.1021/acs.accounts.8b00195