School of Biomedical Sciences and Engineering,
South China University of Technology
Education
PhD. (2011-2017) Biochemistry & Molecular Biology, University of Science and Technology of China
B.S. (2007-2011) Biology, Anhui Normal University
Working Experience
Postdoctoral Fellow (2017.07-2019.09) Institutes for Life Sciences, and School of Medicine, South China University of Technology
Assistant Professor (2019.09-present) School of Biomedical Sciences and Engineering, South China University of Technology
Research Achievements
Dr Shen is interested in the development of nanocarriers for cancer immunotherapy. He has published more than 30 papers in J. Am. Chem. Soc., Nano Lett., Adv. Funct. Mater., Biomaterials et. al. His research is mainly funded by National Natural Science Foundation of China (31800831), Postdoctoral Program for Innovative Talents (BX201700080) and China Postdoctoral Science Foundation (2017M622676).
Research Interests
Drug delivery system, cancer immunotherapy
Representative Publications
1. Hua Huang, Cheng-Tao Jiang, Song Shen* (co-corresponding author), An Liu, Yun-Jiu Gan, Qi-Song Tong, Sen-Biao Chen, Zhu-Xin Gao, Jin-Zhi Du, Jie Cao*, Jun Wang*, Nanoenabled reversal of IDO1-mediated immunosuppression synergizes with immunogenic chemotherapy for improved cancer therapy. Nano Lett. 2019, 19, 5356-65.
2. Jun-Xia Wang#, Song Shen# (co-first author), Dong-Dong Li, Chang-You Zhan, You-Yong Yuan, and Xian-Zhu Yang*, Photoswitchable ultrafast transactivator of transcription (TAT) targeting effect for nanocarrier-based on-demand drug delivery. Adv. Funct. Mater. 2018, 28, 1704806,1-12.
3. Song Shen# (co-first author), Hong-Jun Li#, Kai-Ge Chen, Yu-Cai Wang, Xian-Zhu Yang, Zhe-Xiong Lian, Jin-Zhi Du*, Jun Wang*, Spatial targeting of tumor-associated macrophages and tumor cells with a pH-sensitive cluster nanocarrier for cancer chemoimmunotherapy. Nano Lett. 2017, 17, 3822-29.
4. Chun-Yang Sun#, Song Shen# (co-first author), Cong-Fei Xu, Hong-Jun Li, Yang Liu, Zhi-Ting Cao, Xian-Zhu Yang, Jin-Xing Xia, and Jun Wang*, Tumor acidity-sensitive polymeric vector for active targeted siRNA delivery. J. Am. Chem. Soc. 2015, 137, 15217-24.
5. Song Shen, Chun-Yang Sun, Xiao-Jiao Du, Hong-Jun Li, Yang Liu, Jin-Xing Xia*, Yan-Hua Zhu, Jun Wang*, Co-delivery of platinum drug and siNotch1 with micelleplex for enhanced hepatocellular carcinoma therapy. Biomaterials. 2015, 70, 71-83.
6. Song Shen, Jing-Xing Xia*, Jun Wang*, Nanomedicine-Mediated Cancer Stem Cell Therapy, Biomaterials. 2016, 74, 1-18.
7. Song Shen, Xiao-Jiao Du, Jing Liu, Rong Sun, Yan-Hua Zhu, Jun Wang*, Delivery of bortezomib with nanoparticles for basal-like triple-negative breast cancer therapy. J Control Release. 2015, 208, 14-24.
8. Rong Sun#, Song Shen#(co-first author), Yun-Jiao. Zhang, Cong-Fei Xu, Zhi-Ting Cao, Long-Ping Wen, J.un Wang*，Nanoparticle-facilitated autophagy inhibition promotes the efficacy of chemotherapeutics against breast cancer stem cells, Biomaterials. 2016, 103, 44-55.
9. Yue Zhang#, Song Shen#(co-first author), Gui Zhao, Cong-Fei Xu*, Hou-Bing Zhang, Ying-Li Luo, Zhi-Ting Cao, Jia Shi, Zhi-Bin Zhao, Zhe-Xiong Lian, Jun Wang*,In situ repurposing of dendritic cells with CRISPR/Cas9-based nanomedicine to induce transplant tolerance. Biomaterials. 2019, 217, 119302.
10. Yue-Qiang Zhu, Chao Chen, Zi-Yang Cao, Song Shen* (co-corresponding author), Lai-Sheng Li, Dong-Dong Li, Jun-Xia Wang, Xian-Zhu Yang*, On-demand PEGylation and dePEGylation of PLA-based nanocarriers via amphiphilic mPEG-TK-Ce6 for nanoenabled cancer chemotherapy. Theranostics. 2019, 9, 8312-20.