熊梦华 教授
华南理工大学博士生导师
国家级青年人才项目入选者
电子邮箱：xiongmh@scut.edu.cn
招生方向
生物医学工程（学博、学硕）、生物学（学博、学硕）、材料与化工（工程博士）、生物与医药（工程硕博）
教育/工作经历
2018-至今 华南理工大学 生物医学科学与工程学院 教授
2013-2017 伊利诺伊大学厄巴纳香槟分校（美国） 博士后
2007-2013 中国科学技术大学 高分子化学与物理专业 博士
2003-2007 中国科学技术大学 高分子科学与工程专业 学士
研究概述
近年来熊梦华课题组主要从事膜成孔活性生物材料的设计开发，及其在肿瘤免疫治疗、mRNA疫苗、抗菌等方面的研究。具体研究方向如下：
（1）发展了可靶向识别细菌特异性脂质的螺旋结构抗菌聚肽，阐明螺旋结构在脂质识别中的作用机制；
（2）发展了pH超敏溶瘤纳米去垢剂，实现0.1 pH尺度下膜裂解活性开关的可控激活。
科研成果
近年来，以通讯/第一作者在Nat. Nanotechnol.、PNAS、Angew. Chem. Int. Ed.、JACS、ACS. Nano等国际著名杂志发表30余篇，申请专利20余项，其中PCT专利5项；主持海外高层次引进人才青年项目、国家重点研发项目课题、基金委面上项目等。
代表性研究论文
1. Mingdong Liu#, Liangqi Huang#, Weinan Zhang#, Xiaochuan Wang, Yuanyuan Geng, Yuhao Zhang, Li Wang, Wenbin Zhang, Yun-Jiao Zhang, Shiyan Xiao*, Yan Bao*, Menghua Xiong*, Jun Wang*. A transistor-like pH-sensitive nanodetergent for selective cancer therapy. Nature Nanotechnology, 2022, 17, 541-551.
2. Jihong Wang#, Yueling Yuan#, Chanjuan Su, Yan Bao, Weide Xu, Yandan Yao, Lifang Liang, Yuxuan Zeng, Menghua Xiong*. pH-Ultrasensitive Membranolytic Polyesters with Alternating Sequence of Ionizable and Hydrophobic Groups for Selective Oncolytic Therapy. Journal of the American Chemical Society, 2025, 147, 1008-1016.
3. Yangbin Liang#, Yuhao Zhang#,Yu Huang#, Cheng Xu#, Jingxian Chen, Xinshuang Zhang, Bingchuan Huang, Zhanhui Gan, Xuehui Dong, Songyin Huang, Chengrun Li, Shuyi Jia, Pengfei Zhang, Yueling Yuan, Houbing Zhang, Yucai Wang, Bing Yuan, Yan Bao*, Shiyan Xiao*, Menghua Xiong*. Helicity-directed recognition of bacterial phospholipid via radially amphiphilic antimicrobial peptides. Science Advances, 2024, 10, eadn9435.
4. Yangbin Liang#, Xinshuang Zhang#, Yueling Yuan, Yan Bao* and Menghua Xiong* Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity. Biomaterials Science, 2020, 8, 6858-6866.
5. Zhi-Ting Cao, Li-Qin Gan, Wei Jiang, Ji-Long Wang, Hou-Bing Zhang, Yue Zhang, Yucai Wang, Xianzhu Yang, Menghua Xiong*, Jun Wang*. Protein Binding Affinity of Polymeric Nanoparticles as a Direct Indicator of Their Pharmacokinetics. ACS Nano, 2020, 14, 3563-3575.
6. Menghua Xiong#, Yan Bao#, Xin Xu#, Hua Wang, Zhiyuan Han, Ziyuan Song, Richard M. Peek, Jr, Lichen Yin*, Lin-Feng Chen*, Jianjun Cheng*, Selective killing of Helicobacter pylori with pH-responsive helix-coil conformation transitionable antimicrobial polypeptides. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114, 12675-12680.
7. Menghua Xiong, Zhiyuan Han, Ziyuan Song, Jin Yu, Hanze Ying, Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition, Angewandte Chemie International Edition, 2017, 56, 10826-10829.
8. Menghua Xiong#, Michelle W. Lee#, Rachael A. Mansbach, Ziyuan Song, Yan Bao, Richard M. Peek, Jr, Catherine Yao, Lin-Feng Chen, Andrew L. Ferguson*, Gerard C.L. Wong*, Jianjun Cheng*. Helical Antimicrobial Polypeptides with Radial Amphiphilicity, Proceedings of the National Academy of Sciences of the United States of America, 2015, 112, 13155-13160.