华南理工大学硕士生导师
电子邮箱：luzd@scut.edu,cn
招生方向
生物医学工程、生物学、药学、材料与化工
教育/工作经历
2022- 至今 华南理工大学 医学院 副教授
2017-2019 华南理工大学 医学院 讲师
2012 – 2016 伦敦大学国王学院 药学 博士
2010 – 2011 伦敦大学国王学院 药学 硕士
2005 – 2010 安徽医科大学 临床药理 学士
研究方向
主要从事纳米药物递送进行免疫治疗领域的研究，在构建纳米载体递送核酸药物进行DC等免疫细胞的功能干预，尤其是构建治疗性肿瘤疫苗方面具有良好的积累，取得了一系列成果。针对核酸药物体内递送的障碍，通过对纳米颗粒表面特性的调控，筛选出针对多种不同免疫细胞最优的纳米载体，递送包括siRNA、CRISPR-Cas9等核酸药物进行免疫细胞功能调控。取得了一系列成果。
科研成果
共以第一作者或者通讯作者在Nature Communications, ACS Nano, Advanced Healthcare Materials 等重要学术期刊发表SCI 论文16篇。申请中国发明专利6项。主持国家自然科学青年基金、广东省自然科学基金面上、广州市应用基础研究计划项目等项目，作为研究骨干参与国家重点研发项目4项。
代表性研究论文
1. Qiu-Hong Jian#, Shi-Kun Zhou#, Xin-Yu Tan, Yi-Fang Chen, Shui-Qing Jiang, Si-Yu Qiu, Peng Shi*, Zi-Dong Lu*, Cong-Fei Xu*, Tumor-specific suicide gene nanomedicines enable selective and safe cancer treatment, Nano Research, 2026, 19, 94908294
2. Yun-Cheng Zeng, Yi-Qun Sun, Xue-Qing Zhang, Shu-Jie Liang, Li-Li Chen, Kun-Yu Zhang, Zidong Lu*, Peilong Lai*, Injectable tert-butylphenylacetic acid/acrylated β-cyclodextrin-based hydrogels for co-delivery of CAR-T cells and IL-15 in solid tumor therapy, Materials Today Bio, 2025, 35, 102421.
3. Taian Lin, Yixuan Hou, Xueqing Liu, Ihsan Ullah, Siyu Qiu, Zidong Lu*, Jianyong Qi*, Youyong Yuan*, Fluorinated Proteolysis Targeting Chimeras-Sorafenib Nanoassembly for Epigenetic Remodeling to Combat Multi-Pathway Drug Resistance in Hepatocellular Carcinoma, ACS Nano, 2025, 19 (39), 34659-34676.
4. Qin Fu#, Yicun Li#, Yuheng Lv, Tenghui Ye, Xi Liu, Chener He, Xinchao Liu, Zidong Lu*, Peng Shi*, Fluorescent DNA-Polymer Enables Signal Amplification and Precise Protein Localization in Immunofluorescence Imaging, Analytical Chemistry, 2025, 97, 15844-15854.
5. Yi-Qun Sun#, Ying-Li Luo#, Hui-Xiao Li#, Zi-Lu Wang, Wen-Qi Xu, Zi-Dong Lu *, Cong-Fei Xu*, Functionalized cell membrane-coated nanoparticles induce local immune tolerance for durable survival of allogeneic islet grafts, Biomaterials Science, 2025, 13, 4730-4738.
6. Zi-Lu Wang, Si-Yu Qiu, Yi-Qun Sun, Xiao-Jiao Du, Cong-Fei Xu, Zi-Yang Cao*, Zi-Dong Lu*, An injectable oncolytic hydrogel platform for in situ dendritic cell vaccination to boost antitumor immunity, Biomaterials Science, 2025, 13, 3016-3029.
7. Ziming Huo#, Xiaochun Xie#, Jiying Liu, Fangman Chen, Jianfang Cao, Wen Sun, Yingshuai Wang, Zidong Lu*, Dan Shao*, Engineering a Ru(ii) Nanostructure for Oxygen-Free Photocatalytic Degradation of Environmental Pollutants, ACS Applied Materials & Interfaces, 2025, 17(12), 18493-18501.
8. Chenghu Wu, Wenjuan He, Yue Chen, Jie Cai, Fanjun Zeng*, Zidong Lu*, Jilong Wang*, Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy, Advanced Healthcare Materials, 2023, 12(11), 2203026.
9. Zi-Dong Lu#, Yi-Fang Chen#, Song Shen, Cong-Fei Xu*, Jun Wang, Co-delivery of Phagocytosis Checkpoint Silencer and Stimulator of Interferon Genes Agonist for Synergetic Cancer Immunotherapy, ACS Applied Materials & Interfaces, 2021, 13(25), 29424-29438.
10. Congfei Xu#, Zidong Lu#, Yingli Luo, Yang Liu, Zhiting Cao, Song Shen, Hongjun Li, Jing Liu, Kaige Chen, Zhiyao Chen, Xianzhu Yang, Zhen Gu, Jun Wang*. Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases, Nature Communications, 2018, 9, 4092.