袁友永  教授、博士生导师

电子邮箱: yuanyy@scut.edu.cn

招生方向

化学、材料学、生物医学工程、药学

教育/工作经历

2017.07-至今，华南理工大学，生物医学科学与工程学院，教授

2012.08-2017.06，新加坡国立大学，博士后

2007.09-2012.07，中国科学技术大学，高分子化学与物理，博士

2003.09-207.07，安徽大学，材料化学，学士

研究概述

主要从事生物医用高分子在药物递送、荧光探针和肿瘤治疗等方面的研究。

科研成果

在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.等国际著名杂志上发表SCI学术论文四十余篇，引用2300余次，H因子为25，其中5篇论文入选ESI高被引论文，2篇论文被选为封面文章，申请美国专利2项。承担国家自然科学基金面上项目和中央高校基本业务费等项目，获得国家引进海外高层次人才、广东省珠江人才计划青年拔尖人才、广州市优秀专家。

代表性研究论文

[1] Yalan Tu, Yansong Dong, Kewei Wang, Song Shen, Youyong Yuan,* Jun Wang.* Intercellular Delivery of Bioorthogonal Chemical Receptors for Enhanced Tumor Targeting and Penetration, Biomaterials, 2020, DOI: 10.1016/j.biomaterials.2020.120298.

[2] Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, Youyong Yuan,* Jun Wang.* A General Strategy for Macrotheranostic Prodrug Activation: Synergy by Tumor Acidic Microenvironment and Bioorthogonal Chemistry. Angew. Chem. Int. Ed., 2020, 59, 7168-7172.

[3] Kewei Wang, Yalan Tu, Wang Yao, Qingyu Zong, Xuan Xiao, Rui-Meng Yang,* Xin-Qing Jiang,* Youyong Yuan.* Size-Switchable Nanoparticles with Self-Destructive and Tumor Penetration Characteristics for Site-Specific Phototherapy of Cancer. ACS Appl. Mater. Interfaces, 2020, 12, 6933-6943.

[4] Yansong Dong, Bin Liu,* Youyong Yuan.* AIEgen based drug delivery systems for cancer therapy.J. Control. Release, 2018, 290, 129-137.

[5] Youyong Yuan, Shidang Xu, Xiamin Cheng, Xiaolei Cai, and Bin Liu.* Bioorthogonal Turn-On Probe based on AIEgen for Cancer Cell Imaging and Ablation. Angew. Chem. Int. Ed., 2016, 55, 6457-6461.

[6] Youyong Yuan, Chong-Jing Zhang, and Bin Liu.*Photoactivatable AIE Polymer for Light Controlled Gene Delivery: Concurrent Endo-/Lysosomal Escaping and DNA Unpacking.Angew. Chem. Int. Ed., 2015, 54, 11419–11423.

[7] Youyong Yuan, Chong-Jing Zhang, Meng Gao, Ruoyu Zhang, Ben Zhong Tang, Bin Liu.*Specific Light-up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for Targeted and Image-Guided Photodynamic Ablation of Cancer Cells. Angew. Chem. Int. Ed., 2015, 54, 1780-1786.

[8] Youyong Yuan, Ryan T. K. Kwok, Ben Zhong Tang,* Bin Liu.* Targeted Theranostic Platinum (IV) Prodrug with a Built-in Aggregation-Induced Emission Light-up Apoptosis Sensor for Noninvasive Early Evaluation of its Therapeutic Responses In-situ. J. Am. Chem. Soc., 2014, 136, 2546–2554.

[9] Youyong Yuan, Jie Liu, Bin Liu*. Conjugated Polyelectrolyte based Polyprodrug: Targeted and Imaging Guided Photodynamic and Chemotherapy with On-demand Drug Release upon Single Light Irradiation. Angew. Chem. Int. Ed., 2014, 53, 7163–7168.

[10] Youyong Yuan, Chengqiong Mao, Xiaojiao Du, Jinzhi Du, Feng Wang, Jun Wang.* Surface Charge Switchable Nanoparticles based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor. Adv. Mater., 2012, 24, 5476-5480.