杨显珠 教授


华南理工大学博士生导师

国家优秀青年基金科学基金获得者

电子邮箱：yangxz@scut.edu.cn



教育/工作经历

2017年4月-至今                 华南理工大学       生物医学科学与工程学院   教授(博导)

2013年1月-2017年3月        合肥工业大学     医学工程学院        教授(博导)

2012年1月-2012年12月       中国科学技术大学   生命科学学院        博士后

2006年09月-2011年12月  中国科学技术大学   微尺度物质科学国家实验室  博士

2002年09月-2006年06月  合肥工业大学     化工学院          学士

研究方向

核酸药物递送、高分子药物载体、仿生递送载体

科研成果

以通讯或共同通讯作者在Nat. Nanotechnol.、Nat.Commun.、Adv. Mater.、CellBiomaterials等期刊发表论文100余篇，授权中国发明专利17项，转让3项。

代表性研究论文

1. Yueqiang Zhu, Chaoran Chen, Junbin Chen, Miao Su, Wanling Huang, Sichen Liu, Mingda Yang, Chengqiong Mao, Song Shen*, Xianzhu Yang*, Jun Wang*, In Vivo Generation and Manipulation of CAR-T-mimicking Cells via Magnetic Bispecific Nano-antibody for Solid Tumor Therapy, Advanced Materials, 2026, 38, e20493

2. Ziyang Cao#, Lingwei Hu#, Yunsheng Zheng, Zekai Xiao, Junxia Wang, Xianzhu Yang*, Jun Wang*, Refillable nanodrug-capturing systems for extracellular drug delivery and combined cancer therapy, Cell Biomaterials, 2025, 1, 100053

3. Yi Zhang#, Mingjie Wang#, Ling Ye#, Shengqi Shen, Yuxi Zhang, Xiaoyu Qian, Tong Zhang, Mengqiu Yuan, Zijian Ye, Jin Cai, Xiang Meng, Shiqiao Qiu, Shengzhi Liu, Rui Liu, Weidong Jia, Xianzhu Yang*, Huafeng Zhang*, Xiuying Zhong*, Ping Gao*, HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression, Nature Communications, 2024, 15, 1314.

4. Xiaowan Huang#, Ziyang Cao#, Jieying Qian#, Tao Ding, Yanxia Wu, Hao Zhang, Suqin Zhong, Xiaoli Wang, Xiaoguang Ren, Wang Zhang, Youcui Xu, Guangyu Yao, Xingwu Wang, Xianzhu Yang*, Long-ping Wen*, Yunjiao Zhang*, Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors, Nature Nanotechnology, 2024, 19, 545–553.

5. Chaoran Chen, Yuxi Zhang, Ziyang Cao, Dongdong Li, Yueqiang Zhu, Houjin Jing, Yan Li, Fangzheng Li, Cong-Fei Xu*, Xianzhu Yang*, Jun Wang*, Long-Term Storage Stable Vesicle-Like Nanoparticles of Lipid and Polymer for siRNA and mRNA-Mediated Cancer Immunotherapy, Advanced Functional Materials, 2024, 34, 2402231.

6. Yueqiang Zhu#, Liangjie Jin#, Junbin Chen, Miao Su, Tianmeng Sun, Xianzhu Yang*, Promoting the recruitment, engagement, and reinvigoration of effector T cells via an injectable hydrogel with a supramolecular binding capability for cancer immunotherapy, Advanced Materials, 2023, 35, 2309667.

7. Ziyang Cao, Dongdong Li, Liang Zhao, Mengting Liu, Pengyue Ma, Yingli Luo, Xianzhu Yang*，Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery, Nature Communications, 2022, 13, 2038.

8. Wangcheng Zhang#, Yuxi Zhang#, Yingli Luo#, Senbiao Chen, Qiaoyi Huang, Zhiting Cao, Ming Liang, Xianzhu Yang*, A Nanoconfined Loading Strategy for Highly Efficient siRNA Delivery and Cancer Therapy, Nano Today, 2022, 43, 101418.

9. Yuxi Zhang#, Zhenghai Zhang#, Senlin Li, Liang Zhao, Dongdong Li, Ziyang Cao, Xiaoding Xu, and Xianzhu Yang*, A siRNA-Assisted Assembly Strategy to Simultaneously Suppress “Self” and Upregulate “Eat-Me” Signals for Nanoenabled Chemo-Immunotherapy, ACS Nano, 2021, 15, 16030–16042.

10. Yonghong Song#, Dongdong Li#, Yang Lu*, Kun Jiang, Yi Yang, Yunjun Xu, Liang Dong, Xu Yan, Daishun Ling, Xianzhu Yang*, and Shu-Hong Yu*, Ferrimagnetic mPEG-b-PHEP Copolymer Micelles Loaded with Iron Oxide Nanocubes and Emodin for Enhanced Magnetic Hyperthermia-Chemotherapy, National Science Review, 2020, 7, 723–736