王 均   二级教授、生物医学科学与工程学院院长

                    华南理工大学博士生导师

                    国家自然科学基金杰出青年获得者

                    国家重点研发计划项目负责人

                  “十四五”科技部“高端功能与智能材料”重点研发专项总体专家组成员

                    国际生物材料科学与工程学会联合会会士

                    英国皇家化学会会士

                    中国生物材料学会首届会士

                                                             “万人计划”科技创新领军人才

                                                        科技部“中青年科技创新领军人才”

                                                               中国科学院“百人计划”

                                                               电子邮箱：mcjwang@scut.edu.cn

招生方向

教育/工作经历

  2018-至今      华南理工大学生物医学科学与工程学院          教授、创院院长

  2018-至今      国家人体组织功能重建工程技术研究中心       副主任

  2019-2021      广东省生物医学工程重点实验室         主任

     2016-2020      华南理工大学生命科学研究院          教授、创始人之一

       2014-2016      中科院天然免疫和慢性疾病重点实验室                 教授、副主任

  2006-2016  中国科学技术大学生命科学学院         教授

        合肥微尺度物质科学国家实验室（筹）      研究员

2006.6-2006.8 德国罗斯托克大学医学院                                      高级访问教授

  2004-2006       中国科学技术大学高分子科学与工程系      教授

  2002-2004  约翰霍普金斯大学医学院生物医学工程系     博士后

  1999-2002  约翰霍普金斯医学院新加坡生命医学中心     博士后

  1993-1998       武汉大学 高分子化学与物理专业        博士

  1989-1993  武汉大学 主修化学专业；

             辅修细胞生物学专业            学士

研究方向

纳米生物医学、药物递送系统、肿瘤免疫和生物治疗、mRNA疫苗

科研成果

主要从事生物大分子药物、生物材料及递送系统研究，发展了肿瘤微环境响应的递送载体构建技术，研发了用于核酸药物递送的“CLAN”载体平台和用于抗体药物递送的“纳米适配子”载体技术，在Nat. Biomed. Eng.、Nat.Nanotechnol.、Sci. Transl. Med.、Nat. Commun.、Proc. Natl.Acad. Sci. U. S. A.、Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Adv. Mater.等杂志发表研究论文280余篇，被引用25700余次，H-Index 91；入选科睿唯安“高被引科学家”和爱思唯尔中国高被引学者；申请发明专利60余件，其中PCT专利9件，美国发明专利4件，授权发明专利33件，其中授权美国发明专利1件。

获国家自然科学奖二等奖、广东省科学技术奖一等奖、教育部自然科学奖一等奖、中国生物材料学会科学技术奖、第二届生物医用高分子材料大会“杰出贡献奖”、广东省学校优秀教学成果奖（高等教育一研究生类）一等奖等；主持国家重点研发计划、国家自然科学基金重点等研究项目。

担任Biomaterials副主编，Acta Biomaterialia、Journal of Controlled Release、Aggregate杂志编委；ChemNanoMat、Advanced Healthcare Materials杂志顾问编委，《生物材料科学与工程》丛书执行副总主编，《中国卫生标准管理》杂志社第一届药品监管科学与现代药事管理编委会副主编，中国生物材料学会常务理事，中国生物材料学会智能仿生生物材料分会主任委员，中美纳米医学与纳米生物技术学会创会委员等。

代表性研究论文

1. Ya-Nan Fan, Long Zhu, Yu-Xin Qing, Si-Yi Ye, Qian-Ni Ye, Xiao-Yi Huang, Dong-Kun Zhao, Tai-Yu Tian, Fang-Chao Li, Guan-Rong Yan, Xian-Zhu Yang, Song Shen*, Jun Wang*, Engineering Multi-Specific Nano-Antibodies for Cancer Immunotherapy, Nature Biomedical Engineering, 2025 9, 2124–2140

2. Shi-Kun Zhou#, Jing-Tong Luo#, Yi-Fang Chen, Zi-Dong Lu, Qiu-Hong Jian, Shui-Qing Jiang, Jing Li, Xue-Qin Zhang, Xin-Yu Tan, Xian-Zhu Yang, Cong-Fei Xu*, Jun Wang*, Muscle-specific Gene Editing Therapy via Mammalian Fusogen-Directed Virus-Like Particles, Nature Communications, 2025, 16, 9145.

3. Yue Wang#, Min Yang#, Bao-Yue Zhang, Gui Zhao, Shi-Kun Zhou, Zi-Dong Lu, Cong-Fei Xu*, Jun Wang*, Leveraging T-Cell-Specific Fusogenicity of HIV for invivo mRNA Delivery to Produce Human CAR-T Cells, Cell Biomaterials, 2025, 1, 100011

4. Yueqiang Zhu, Chaoran Chen, Junbin Chen, Miao Su, Wanling Huang, Sichen Liu, Mingda Yang, Chengqiong Mao, Song Shen*, Xianzhu Yang*, Jun Wang*, In Vivo Generation and Manipulation of CAR-T-mimicking Cells via Magnetic Bispecific Nano-antibody for Solid Tumor Therapy, Advanced Materials, 2026, 10.1002/adma.202520493

5. Qian-Ni Ye, Long Zhu, Jie Liang, Dong-Kun Zhao, Tai-Yu Tian, Ya-Nan Fan, Si-Yi Ye, Hua Liu, Xiao-Yi Haung, Zhi-Ting Cao, Song Shen*, Jun Wang*, Orchestrating NK and T cells via tri-specific nano-antibodies for synergistic antitumor immunity, Nature Communications, 2024, 15, 6211

6. Gui Zhao#, Yue Zhang#, Cong-Fei Xu*, Jun Wang*, In Vivo Production of CAR-T Cells Using Virus-mimetic Fusogenic Nanovesicles, Science Bulletin, 2024, 69, 354-366

7. Yansong Dong#, Ye Liu#, Yalan Tu, Youyong Yuan*, Jun Wang*, AIEgens Cross-linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity-Mediated Click Reaction, Angewandte Chemie International Edition, 2023, 62, e202310975

8. Yue Wang#, Shi-Kun Zhou#, Yan Wang, Zi-Dong Lu, Yue Zhang, Cong-Fei Xu*, Jun Wang*, Engineering Tumor-Specific Gene Nanomedicine to Recruit and Activate T Cells for Enhanced Immunotherapy, Nature Communications, 2023, 14, 1993

9. Mingdong Liu#, Liangqi Huang#, Weinan Zhang#, Xiaochuan Wang, Yuanyuan Geng, Yuhao Zhang, Li Wang, Wenbin Zhang, Yun-Jiao Zhang, Shiyan Xiao*, Yan Bao*, Menghua Xiong*, Jun Wang*, A Transistor-Like pH-Sensitive Nanodetergent for Selective Cancer Therapy, Nature Nanotechnology, 2022, 17, 541-551

10. Shasha He#, Jing Liu#, Chi Zhang, Jun Wang*, Kanyi Pu*, Semiconducting Polymer Nano-regulators with Cascading Activation for Photodynamic Cancer Immunotherapy, Angewandte Chemie International Edition, 2022, 61, e202116669

11. Jing Liu#, Shasha He#, Yingli Luo, Yue Zhang, Xiaojiao Du, Cheng Xu, Kanyi Pu*, Jun Wang*, Tumor-Microenvironment-Activatable Polymer Nano-Immunomodulator for Precision Cancer Photoimmunotherapy, Advanced Materials, 2022, 34, 2106654

12. Jing Liu, Si Si Liew, Jun Wang*, Kanyi Pu*, Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines, Advanced Materials, 2022, 34, 2103790

13. Cheng-Tao Jiang#, Kai-Ge Chen#, An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen*, Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang*, Immunomodulating Nano-Adaptors Potentiate Antibody-Based Cancer Immunotherapy, Nature Communications, 2021, 12, 1359

14. Shuya Li#, Min Li#, Shaohu Huo, Qin Wang, Jing Chen, Shenggang Ding, Zhutian Zeng, Wenchao Zhou, Yucai Wang*, Jun Wang*, Voluntary-Opsonization-Enabled Precision Nanomedicines for Inflammation Treatment, Advanced Materials, 2021, 33, 2006160

15. Yansong Dong, Yalan Tu, Kewei Wang, Congfei Xu, Youyong Yuan*, Jun Wang*, A General Strategy for Macrotheranostic Prodrug Activation: Synergy between the Acidic Tumor Microenvironment and Bioorthogonal Chemistry, Angewandte Chemie International Edition, 2020, 59, 7168-7172

16. Jin-Zhi Du*, Hong-Jun Li, Jun Wang*, Tumor-Acidity Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles to Overcome Delivery Barriers in Cancer Nanomedicine, Accounts of Chemical Research, 2018, 51, 2848-2856

17. Cong-Fei Xu#, Zi-Dong Lu#, Ying-Li Luo, Yang Liu, Zhi-Ting Cao, Song Shen, Hong-Jun Li, Jing Liu, Kai-Ge Chen, Zhi-Yao Chen, Xian-Zhu Yang, Zhen Gu, Jun Wang*, Targeting of NLRP3 Inflammasome with Gene Editing for the Amelioration of Inflammatory Diseases, Nature Communications, 2018, 9, 4092

18. Hong-Jun Li#, Jin-Zhi Du#, Xiao-Jiao Du#, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-Hua Zhu, Shu-Ming Nie*, Jun Wang*, Stimuli-responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy, PNAS, 2016, 113, 4164-4169

19. Chun-Yang Sun#, Yang Liu#, Jin-Zhi Du#, Zhi-Ting Cao, Cong-Fei Xu, Jun Wang*, Facile Generation of Tumor pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery, Angewandte Chemie International Edition, 2016, 128,1022-1026

20. Chun-Yang Sun#, Song Shen#, Cong-Fei Xu, Hong-Jun Li, Yang Liu, Zhi-Ting Cao, Xian-Zhu Yang, Jin-Xing Xia, Jun Wang*, Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery, Journal of the American Chemical Society, 2015, 137, 15217–15224

21. Xian-Zhu Yang#, Xiao-Jiao Du#, Yang Liu, Yan-Hua Zhu, Yang-Zhong Liu, Ya-Ping Li, Jun Wang*, Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy, Advanced Materials, 2014, 26, 931-936

22. You-Yong Yuan#, Chen-Qiong Mao#, Xiao-Jiao Du, Jin-Zhi Du, Feng Wang, Jun Wang*, Surface Charge Switchable Nanoparticles based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor, Advanced Materials, 2012, 24, 5476-5480

23. Yuan-Zeng Min, Cheng-Qiong Mao, Si-Ming Chen, Guo-Lin Ma, Jun Wang*, Yang-Zhong Liu*, Combating the Drug Resistance of Cisplatin Using a Platinum Prodrug Based Delivery System, Angewandte Chemie-International Edition, 2012, 51, 6742-6747

24. Yan-Dan Yao#, Tian-Meng Sun#, Song-Yin Huang, Shuang Dou, Ling Lin, Jia-Ning Chen, Jian-Bin Ruan, Cheng-Qiong Mao, Feng-Yan Yu, Mu-Sheng Zeng, Jian-Ye Zang, Qiang Liu, Feng-Xi Su, Peter Zhang, Judy Lieberman*, Jun Wang*, Erwei Song*, Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis, Science Translational Medicine, 2012, 4, 130ra48

25. Meng-Hua Xiong#, Yan Bao#, Xian-Zhu Yang, Yu-Cai Wang, Bao-Lin Sun*, Jun Wang*, Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery, Journal of the American Chemical Society, 2012, 134, 4355-4362

论文详细列表：http://www.researcherid.com/rid/F-9033-2011