许从飞 副教授、博士生导师
华南理工大学生物医学科学与工程学院
E-mail: xucf@scut.edu.cn
招生方向
生物医学工程、生物学、药学、材料与化工
教育/工作经历
2019-至今，华南理工大学，生物医学科学与工程学院，副教授（博导）
2017-2019，华南理工大学，博士后
2012-2017，中国科学技术大学，细胞生物学专业，博士
2008-2012，中国科学技术大学，生物技术专业，学士
研究概述
研究方向：生物医用高分子材料；药物递送载体；基因编辑；基因治疗。针对临床疾病对新型治疗手段的迫切需求和药物递送的关键难题，将纳米递送载体技术与CRISPR-Cas9基因编辑技术、分子生物学和细胞生物学技术相结合，设计纳米药物在体内特异性、高效性地调控靶细胞功能，用于肿瘤、炎症性疾病和自身免疫性疾病等的治疗研究。
科研成果
共发表SCI论文48篇，论文总引用次数大于3800次；以第一作者或者通讯作者在Nature Communications、Science Bulletin、Nano Today、Nano Letters、ACS Nano、Small、Biomaterials、Advanced Drug Delivery Reviews等杂志发表SCI论文25篇，三篇入选ESI高被引论文；授权发明专利4项。主持广东省自然科学基金杰出青年项目、国家自然科学基金面上项目、青年基金等多个项目。
代表性研究论文
1. Gui Zhao#, Yue Zhang#, Cong-Fei Xu*, Jun Wang*, In vivo production of CAR-T cells using virus-mimetic fusogenic nanovesicles, Science Bulletin, 2023, 10.1016/j.scib.2023.11.055.
2. Yue Wang#, Shi-Kun Zhou#, Yan Wang, Zi-Dong Lu, Yue Zhang, Cong-Fei Xu*, Jun Wang*, Engineering tumor-specific gene nanomedicine to recruit and activate T cells for enhanced immunotherapy, Nature Communications, 2023, 14, 1993.
3. Yue Zhang#, Gui Zhao#, Jing Liu, Hou-Bing Zhang, Yue Wang, Ying-Li Luo, Zi-Dong Lu, Xiao-Jiao Du, Song Shen, Jin-Zhi Du, Cong-Fei Xu*, Jun Wang*, Gene-activating nanomedicine for the tumor-oriented infiltration of T cells to enhance immunotherapy against solid tumors, Nano Today, 2023, 52, 101992.
4. Yue Zhang#, Gui Zhao#, Yi-Fang Chen, Shi-Kun Zhou, Yue Wang, Yi-Qun Sun, Song Shen, Cong-Fei Xu*, Jun Wang*, Engineering nano-clustered multivalent agonists to cross-link TNF receptors for cancer therapy, Aggregate, 2023, 4(6), e393.
5. Cong-Fei Xu#, Guo-Jun Chen#, Ying-Li Luo, Yue Zhang, Gui Zhao, Zi-Dong Lu, Anna Czarna, Zhen Gu*, Jun Wang*, Rational designs of in vivo CRISPR-Cas delivery systems, Advanced Drug Delivery Reviews, 2021, 168, 3−29.
6. Yue Zhang#, Song Shen#, Gui Zhao, Cong-Fei Xu*, Hou-Bing Zhang, Ying-Li Luo, Zhi-Ting Cao, Jia Shi, Zhi-Bin Zhao, Zhe-Xiong Lian, Jun Wang*, In situ repurposing of dendritic cells with CRISPR/Cas9-based nanomedicine to induce transplant tolerance, Biomaterials, 2019, 217, 119302.
7. Cong-Fei Xu#, Dong-Dong Li#, Zhi-Ting Cao, Meng-Hua Xiong, Xian-Zhu Yang*, Jun Wang*, Facile hydrophobization of siRNA with anticancer drug for non-cationic nanocarrier-mediated systemic delivery, Nano Letters, 2019, 19, 2688−2693.
8. Cong-Fei Xu, Shoaib Iqbal, Song Shen, Ying-Li Luo, Xian-Zhu Yang*, Jun Wang*, Development of “CLAN” nanomedicine for nucleic acid therapeutics, Small, 2019, 15, e1900055.
9. Cong-Fei Xu#, Zi-Dong Lu#, Ying-Li Luo, Yang Liu, Zhi-Ting Cao, Song Shen, Hong-Jun Li, Jing Liu, Kai-Ge Chen, Zhi-Yao Chen, Xian-Zhu Yang, Zhen Gu, Jun Wang*, Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases, Nature Communications, 2018, 9, 4092.
10. Yang Liu#, Zhi-Ting Cao#, Cong-Fei Xu*, Zi-Dong Lu, Ying-Li Luo, Jun Wang*, Optimization of lipid-assisted nanoparticle for disturbing neutrophils-related inflammation, Biomaterials, 2018, 172, 92−104.