许从飞 教授
E-mail: xucf@scut.edu.cn
招生方向
生物医学工程、生物学、生物与医药、材料与化工
教育/工作经历
2025-至今 华南理工大学 教授
2019-2024 华南理工大学 副教授
2017-2019 华南理工大学 博士后
2012-2017 中国科学技术大学 博士
2008-2012 中国科学技术大学 学士
研究概述
研究方向：生物医用高分子材料；靶向纳米载体；生物大分子递送
针对临床疾病对新型治疗手段的迫切需求和药物递送的关键难题，利用材料学、合成生物学、纳米技术等领域的前沿方法，设计靶向纳米载体进行生物大分子药物的精准递送，在体内特异性、高效性地调控细胞功能，用于肿瘤、自身免疫性疾病、遗传性疾病等的治疗。
科研成果
共发表SCI论文60余篇，其中以通讯作者或者第一作者在Nature Communications、Cell Biomaterials、Science Bulletin、ACS Nano、Advanced Functional Materials、Nano Letters、Nano Today、Small、Biomaterials等杂志发表SCI论文30余篇；申请发明专利17项（已授权5项）；主持基金委优青、面上、广东省杰青等项目，参与国家重点研发计划、广州市重点研发计划等项目；获2021年度广东省自然科学一等奖。
代表性研究论文
1. Yi-Fang Chen#, Shi-Kun Zhou#, Qiu-Hong Jian, Min Yang, Li−Li Chen, Shui-Qing Jiang, Cong-Fei Xu*, Jun Wang*, A Dual-Fusogenic Virus-like Vector Enables Direct Cytosolic Delivery of mRNA Vaccines to Dendritic Cells, ACS Nano, 2026, .
2. Shi-Kun Zhou#, Jing-Tong Luo#, Yi-Fang Chen, Zi-Dong Lu, Qiu-Hong Jian, Shui-Qing Jiang, Jing Li, Xue-Qin Zhang, Xin-Yu Tan, Xian-Zhu Yang, Cong-Fei Xu*, Jun Wang*, Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles, Nature Communications, 2025, 16, 9145.
3. Yue Wang#, Min Yang#, Bao-Yue Zhang, Gui Zhao, Shi-Kun Zhou, Zi-Dong Lu, Cong-Fei Xu*, Jun Wang*, Leveraging T-cell-specific fusogenicity of HIV for in vivo mRNA delivery to produce human CAR-T cells, Cell Biomaterials, 2025, 1, 100011.
4. Chaoran Chen, Yuxi Zhang, Ziyang Cao, Dongdong Li, Yueqiang Zhu, Houjin Jing, Yan Li, Fangzheng Li, Cong-Fei Xu*, Xianzhu Yang*, Jun Wang*, Long-Term Storage Stable Vesicle-Like Nanoparticles of Lipid and Polymer for siRNA and mRNA-Mediated Cancer Immunotherapy, Advanced Functional Materials, 2024, 34(44), 2406101.
5. Gui Zhao#, Yue Zhang#, Cong-Fei Xu*, Jun Wang*, In vivo production of CAR-T cells using virus-mimetic fusogenic nanovesicles, Science Bulletin, 2024, 69(3), 354−366.
6. Yue Wang#, Shi-Kun Zhou#, Yan Wang, Zi-Dong Lu, Yue Zhang, Cong-Fei Xu*, Jun Wang*, Engineering tumor-specific gene nanomedicine to recruit and activate T cells for enhanced immunotherapy, Nature Communications, 2023, 14, 1993.
7. Yue Zhang#, Gui Zhao#, Jing Liu, Hou-Bing Zhang, Yue Wang, Ying-Li Luo, Zi-Dong Lu, Xiao-Jiao Du, Song Shen, Jin-Zhi Du, Cong-Fei Xu*, Jun Wang*, Gene-activating nanomedicine for the tumor-oriented infiltration of T cells to enhance immunotherapy against solid tumors, Nano Today, 2023, 52, 101992.
8. Yue Zhang#, Gui Zhao#, Yi-Fang Chen, Shi-Kun Zhou, Yue Wang, Yi-Qun Sun, Song Shen, Cong-Fei Xu*, Jun Wang*, Engineering nano-clustered multivalent agonists to cross-link TNF receptors for cancer therapy, Aggregate, 2023, 4(6), e393.
9. Cong-Fei Xu#, Dong-Dong Li#, Zhi-Ting Cao, Meng-Hua Xiong, Xian-Zhu Yang*, Jun Wang*, Facile hydrophobization of siRNA with anticancer drug for non-cationic nanocarrier-mediated systemic delivery, Nano Letters, 2019, 19, 2688−2693.
10. Cong-Fei Xu#, Zi-Dong Lu#, Ying-Li Luo, Yang Liu, Zhi-Ting Cao, Song Shen, Hong-Jun Li, Jing Liu, Kai-Ge Chen, Zhi-Yao Chen, Xian-Zhu Yang, Zhen Gu, Jun Wang*, Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases, Nature Communications, 2018, 9, 4092.