沈松 特聘研究员、博士生导师
电子邮箱: shensong@scut.edu.cn
招生方向
生物学、生物医学工程、药学
教育/工作经历
2019.09-至今，华南理工大学生物医学科学与工程学院，助理教授/研究员
2017.07-2019.08，华南理工大学，医学院，博士后
2011.09-2017.06，中国科学技术大学，生命科学学院，生物化学与分子生物，博士
2007.09-2011.07，安徽师范大学，生命科学学院，生物技术专业，学士
研究概述
主要研究兴趣包括药物载体与递送、肿瘤免疫治疗等，是材料学、生命科学和医学等多学科交叉的方向。近年来，致力于构建和优化通用型、特异性抗体固定平台，用于发展双/多特异性纳米抗体，以期为肿瘤免疫治疗提供新策略、新技术和新产品。
科研成果
近年来，在Nat. Commun.、J. Am. Chem. Soc.、Nano Lett.等国际知名SCI期刊发表学术论文30余篇，他引1200余次，H-index为21，其中第一/共第一作者及共通讯作者论文13篇（IF > 10论文8篇，ESI高被引论文1篇，单篇最高他引168次）。申请中国发明专利3项，PCT国际发明专利2项，参与撰写1部著作的章节。先后主持国家自然科学基金面上项目、青年科学基金以及博士后创新人才支持计划等，作为骨干成员参与了科技部国家重点研发计划等项目。ACS Nano、Biomaterials、J. Controlled Release等杂志特邀审稿人。
代表性研究论文
[1] Hua Huang, Cheng-Tao Jiang, Song Shen*, An Liu, Yun-Jiu Gan, Qi-Song Tong, Sen-Biao Chen, Zhu-Xin Gao, Jin-Zhi Du, Jie Cao*, Jun Wang*, Nanoenabled reversal of IDO1-mediated immunosuppression synergizes with immunogenic chemotherapy for improved cancer therapy. Nano Lett. 2019, 19, 5356-65.
[2] Yue-Qiang Zhu, Chao Chen, Zi-Yang Cao, Song Shen*, Lai-Sheng Li, Dong-Dong Li, Jun-Xia Wang, Xian-Zhu Yang*, On-demand PEGylation and dePEGylation of PLA-based nanocarriers via amphiphilic mPEG-TK-Ce6 for nanoenabled cancer chemotherapy. Theranostics. 2019, 9, 8312-20.
[3] Song Shen, Chun-Yang Sun, Xiao-Jiao Du, Hong-Jun Li, Yang Liu, Jin-Xing Xia*, Yan-Hua Zhu, Jun Wang*, Co-delivery of platinum drug and siNotch1 with micelleplex for enhanced hepatocellular carcinoma therapy. Biomaterials. 2015, 70, 71-83.
[4] Song Shen#, Hong-Jun Li#, Kai-Ge Chen, Yu-Cai Wang, Xian-Zhu Yang, Zhe-Xiong Lian, Jin-Zhi Du*, Jun Wang*, Spatial targeting of tumor-associated macrophages and tumor cells with a pH-sensitive cluster nanocarrier for cancer chemoimmunotherapy. Nano Lett. 2017, 17, 3822-29.
[5] Song Shen, Jing-Xing Xia*, Jun Wang*, Nanomedicine-mediated cancer stem cell therapy, Biomaterials. 2016, 74, 1-18.
[6] Song Shen, Xiao-Jiao Du, Jing Liu, Rong Sun, Yan-Hua Zhu, Jun Wang*, Delivery of bortezomib with nanoparticles for basal-like triple-negative breast cancer therapy. J Control Release. 2015, 208, 14-24.
[7] Jun-Xia Wang#, Song Shen#, Dong-Dong Li, Chang-You Zhan, You-Yong Yuan, and Xian-Zhu Yang*, Photoswitchable ultrafast transactivator of transcription (TAT) targeting effect for nanocarrier-based on-demand drug delivery. Adv. Funct. Mater. 2018, 28, 1704806,1-12.
[8] Chun-Yang Sun#, Song Shen#, Cong-Fei Xu, Hong-Jun Li, Yang Liu, Zhi-Ting Cao, Xian-Zhu Yang, Jin-Xing Xia, and Jun Wang*, Tumor acidity-sensitive polymeric vector for active targeted siRNA delivery. J. Am. Chem. Soc. 2015, 137, 15217-24.