沈松 教授
华南理工大学博士生导师
华南理工大学兴华人才精英学者
国家优青
广东省杰青
电子邮箱: shensong@scut.edu.cn
招生方向
生物学、生物医学工程、药学
教育/工作经历
2025.10-至今 华南理工大学 生物医学科学与工程学院 教授
2019.09-2025.10 华南理工大学 生物医学科学与工程学院 副教授
2017.07-2019.08 华南理工大学 医学院 博士后
2011.09-2017.06 中国科学技术大学 生命科学学院 博士
2007.09-2011.07 安徽师范大学 生命科学学院 学士
研究概述
围绕生物大分子药物与免疫工程前沿，聚焦抗体、细胞因子、核酸等生物大分子的递送与功能重构，开展材料科学、生命科学与医学深度交叉研究。近年来重点发展通用型、可编程的抗体固定与组装平台，构建双/多特异性纳米抗体体系，探索其在肿瘤免疫治疗中的新作用机制与应用潜力。同时，结合抗体工程与免疫细胞工程化技术，开展CAR-T、CAR-巨噬细胞等新型免疫细胞治疗策略研究，拓展其在肿瘤及免疫相关疾病中的应用。
科研成果
近年来，在Nature Biomedical Engineering、Nature Communications、Advanced Materials、Nano Today等国际知名学术期刊共发表论文50余篇，总被引5000余次，其中以一作或通讯作者发表的论文30篇。申请中国发明专利、美国发明专利、PCT专利共17项，已授权8项；参与撰写2部著作的章节。先后主持国家自然科学基金青年科学基金（B类）[原“优青”]、广东省自然科学基金杰出青年项目、国家自然科学基金面上项目（3项）、青年科学基金项目及博士后创新人才支持计划等，作为核心骨干参与国家重点研发计划、广州市重点领域研发计划等项目。
代表性研究论文
1. Ya-Nan Fan, Long Zhu, Yu-Xin Qing, Si-Yi Ye, Qian-Ni Ye, Xiao-Yi Huang, Dong-Kun Zhao, Tai-Yu Tian, Fang-Chao Li, Guan-Rong Yan, Xian-Zhu Yang,Song Shen*, Jun Wang*, Engineering multi-specific nano-antibodies based on a versatile nano-adaptor for cancer immunotherapy, Nature Biomedical Engineering, 2025, doi: 10.1038/s41551-025-01425-5.
2. Qian-Ni Ye, Long Zhu, Jie Liang, Dong-Kun Zhao, Tai-Yu Tian, Ya-Nan Fan, Si-Yi Ye, Hua Liu, Xiao-Yi Haung, Zhi-Ting Cao, Song Shen*, Jun Wang*, Orchestrating NK and T cells via tri-specific Nano-Antibodies for synergistic antitumor immunity, Nature Communications, 2024, 15, 6211.
3. Cheng-Tao Jiang#, Kai-Ge Chen#, An Liu, Hua Huang, Ya-Nan Fan, Dong-Kun Zhao, Qian-Ni Ye, Hou-Bing Zhang, Cong-Fei Xu, Song Shen*, Meng-Hua Xiong, Jin-Zhi Du, Xian-Zhu Yang, Jun Wang*, Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy. Nature Communications, 2021, 12, 1359.
4. Yueqiang Zhu, Chaoran Chen Junbin Chen Miao Su Wanling Huang1 Sichen Liu Mingda Yang，Chengqiong Mao Song Shen*, Xianzhu Yang*, Jun Wang*, In Vivo Generation and Manipulation of CAR-T-mimicking Cells via Magnetic Bispecific Nano-antibody for Solid Tumor Therapy, Advanced Materials, 2026, e20493.
5. Hua Huang#, Qi-Song Tong#, Jing-Yang Zhang, Rong Liu, Yang Chen, Song Shen*, Jin-Zhi Du*, Jun Wang, Phagocytosis-Activating Nanocomplex Orchestrates Macrophage-Mediated Cancer Immunotherapy, Advanced Materials, 2025, e2500982.
6. Jie Liang#, Dong-Kun Zhao#, Hao-Ming Yin, Tai-Yu Tian, Jian-Kang Kang, Song Shen*, Jun Wang, Combinatorial screening of nanomedicines in patient-derived cancer organoids facilitates efficient cancer therapy, Nano Today, 2025, 61, 102665.
7. Boya Yu, Zekai Xiao, Shuaiqi Shao, Mingda Yang, Houjin Jing, Song Shen*, Ziyang Cao*, and Xianzhu Yang*, An Iron-Polyphenol Decorated siRNA-Encapsulated Nanomedicine Multifacetedly Promoted Macrophage Phagocytosis for Synergistic Ferroptosis-Immunotherapy, Advanced Functional Materials, 2025, 2417548.
8. Zheng Zhang#, Ya-Nan Fan#, Si-Qi Jiang, Ya-Jing Ma, Yao-Ru Yu, Yu-Xin Qing, Qian-Ru Li, Yi-Lin Liu, Song Shen*, Jun Wang*, Recent Advances in mRNA Delivery Systems for Cancer Therapy, Advanced Science, 2025, e17571.
9. Qi-Song Tong#, Hua Huang#, Hui-Han Yu, Rong Liu, Song Shen*, Jin-Zhi Du*, A Size-switchable Nanocluster Remodels the Immunosuppressive Microenvironment of Tumor and Tumor-draining Lymph Nodes for Improved Cancer Immunotherapy, Biomaterials, 2025, 315, 122910.
10. Kai-Ge Chen#, An Liu#, Cheng-Tao Jiang, Dong-Kun Zhao, Qian-Ni Ye, Yu-Qi Liao, Cong-Fei Xu, Song Shen*, Jun Wang, Dual-functional super bispecific nano-antibodies derived from monoclonal antibodies potentiate the antitumor effect of innate immune cells. Nano Today 2021, 39, 101209.