PI
| 张云娇 教授 华南理工大学博士生导师 国家优青、广东省杰青、中科院优博获得者 电子邮箱：zhangyunjiao@scut.edu.cn |
个人简介
教授、博士生导师，国家优青（2022）、广东省杰出青年（2018）、中科院优博（2014）。近年来，致力于纳米生物医学前沿交叉领域，研究方向为调控蛋白质稳态的纳米策略。针对生命健康与疾病防治中的重大挑战，创造性地以调控细胞自稳态的自噬效应为切入点，设计具有特殊生物活性的纳米材料并建立可控构筑方法，发现了纳米结构与自噬的构效关系，阐明了纳米材料调控自噬过程及细胞命运的分子机制，在此基础上发展了多种有效干预致病蛋白稳态及肿瘤耐药性的治疗新策略。共发表SCI论文50余篇, 其中以第一/通讯作者在Nature Mater.、Nature Commun.、Acc. Chem ResAdv. Func. Mater.等重要国际学术期刊发表SCI 论文20篇。授权中国发明专利10 项、授权美国专利1 项及PCT 2项。受Springer出版社邀请撰写Springer Theses系列丛书一册，已于2022年1月全球发行。受邀担任Exploration杂志青年编委、Smart Mater in Med杂志客座编辑。担任中国生物物理学会纳米生物学分会青年委员、广东省精准医学应用学会纳米医学分会委员及广东省精准医学应用学会分子影像学分会委员。
教育/工作经历
2019-至今 华南理工大学 教授
2017—2019 华南理工大学 副教授
2012—2017 中国科学技术大学 副研究员
2007—2012 中国科学技术大学 生化与分子生物学理学博士
2003—2007 哈尔滨工业大学 生物工程专业工学学士
科学研究情况
近年来一直致力于利用纳米策略调控蛋白质稳态及诊疗用纳米药物的开发。共发表SCI论文50余篇, 其中以第一/通讯作者在Nature Materials、Nature Communications、Account of Chemical Research、Advanced Materials、Advanced Functional Materials等国际重要学术期刊发表SCI 论文20余篇。授权中国发明专利10项、授权美国发明专利1 项。主持国家自然科学基金优秀青年项目、面上项目，广东省杰出青年项目、广东省重点研发子课题及广东省区域联合基金重点项目等10余项。担任Exploration杂志青年编委、Smart Mater in Med杂志客座编辑。担任中国生物物理学会纳米生物学分会青年委员、广东省精准医学应用学会分子影像分会常务委员。
负责医学院本硕博贯穿课程《医学实验动物学》及本科生《医学创新思维培养》的教学。
招生专业
学术学位博士生：生物学、基础医学、生物医学工程
学术学位硕士：生物学、基础医学、生物医学工程
专业学位硕士：药学
科研方向
1）开发调控蛋白质稳态的纳米药物；
2）工程化纳米材料在重大疾病诊疗和肿瘤免疫治疗中的应用研究；
3）功能性短肽介导的药物输运。
实验室近期论文
1.Hui Wang, Yu Guan, Chun Li, Jia Chen, Shaoyu Yue, Jieying Qian, Bangshun Dai, Changqin Jiang, Chenghao Wen, Longping Wen, Chaozhao Liang,* Yunjiao Zhang* and Li Zhang*. PEGylated Manganese–Zinc Ferrite Nanocrystals Combined with Intratumoral Implantation of Micromagnets Enabled Synergetic Prostate Cancer Therapy via Ferroptotic and Immunogenic Cell Death. Small 2207077 (2023)(IF:15.153)
2.Ziying Chen#, Pin Chen#, Yangyang Zhu, Jieying Qian, Xiaowan Huang, Wang Zhang, Hao Zhang, Qing Mo, Yutong Lu, Yunjiao Zhang*, 2D Cobalt Oxyhydroxide Nanozymes Inhibit Inflammation by Targeting the NLRP3 Inflammasome，Advanced Functional Materials, 2214693(2023)(IF:19.924)
3.Hao Zhang, Wang Zhang, Bochuan Hu, Xiaohua Qin, Tianxiang Yi, Yayi Ye, Xiaowan Huang, Yang Song, Zhenyu Yang, Jieying Qian*, Yunjiao Zhang*, Precise pancreatic cancer therapy through targeted degradation of mutant p53 protein by cerium oxide nanoparticles, J Nanobiotechnology, 1;21(1):117.(2023)(IF:9.429)
4.Tianxiang Yi#, Jieying Qian#*, Yayi Ye, Hao Zhang, Xin Jin, Meimei Wang, Zhenyu Yang, Wang Zhang, Longping Wen*, Yunjiao Zhang*, Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp53 Proteins. ACS Appl Mater Interfaces, 11;15(1):511-523( 2023)(IF:10.383)
5.Wenwei Jiang# , Suqin Zhong#, Ziying Chen#, Jieying Qian, Xiaowan Huang, Hao Zhang, Longping Wen*, Yunjiao Zhang*, Guangyu Yao*, 2D-CuPd nanozyme overcome tamoxifen resistance in breast cancer by regulating the PI3K/AKT/mTOR pathway. Biomaterials, 294:121986(2023)(IF: 15.304)
6.Minjie Zhang#, Xin Jin#, Meng Gao*, Yunjiao Zhang*, Ben Zhong Tang*. A Self-Reporting Fluorescent Salicylaldehyde–Chlorambucil Conjugate as a Type-II ICD Inducer for Cancer Vaccines. Advanced Materials 34, 36 (2022) (IF=32.086)
7.Bochuan Hu#, Xiaohui Xiao#, Pin Chen#, Jieying Qian, Guotao Yuan, Yayi Ye, Lingli Zeng, Suqin Zhong, Xiaoli Wang, Xiaohua Qin, Yuedong Yang, Yue Pan* & Yunjiao Zhang*, Enhancing Anti-tumor Effect of Ultrasensitive Bimetallic RuCu Nanoparticles as Radiosensitizers with Dual Enzyme-Like Activities, Biomaterials (2022) (IF: 15.304)
8.Zikai Zhou#, Jieying Qian#, Kai Liu*, Yunjiao Zhang*, Meng Gao*, Ben Zhong Tang*, A Water-Stable and Red-Emissive Radical Cation for Mutp53 Cancer Therapy, Angewandte Chemie International Edition (2022). (IF:16.823)
9.Yangyang Zhu#, Hao Zhang#, Huawei Mao#, Suqin Zhong, Yubing Huang, Sirong Chen, Kai Yan, Zhibin Zhao, Xiaohan Hao, Yue Zhang, Han Yao, Xiaowan Huang, Meimei Wang, Wenbin Zhang, Juan Li, Guangxun Meng, Xiaohua Qin, Zhiming Ye, Jiani Shen, Yang Song, Youcui Xu, Zhenyu Yang, Liansheng Wang*, Yunjiao Zhang*, Longping Wen* FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system.Cell Death & Differentiation (2022)(IF:12.067)
10.Meimei Wang, Zhenyu Yang, Yang Song, Pengfei Wei, Nestor Ishiwme, Liansheng Wang, Hao Zhang, Manman Jing, Meng Gao*, Longping Wen*, Yunjiao Zhang*. Proteasomal and autophagy-mediated degradation of mutp53 proteins through mitochondria-targeting aggregation-induced-emission materials. Acta biomaterialia, 150, 402–412 (2022) (IF:10.633)
11.Manman Jing#, Yafei Li #, Meimei Wang, Hao Zhang, Pengfei Wei, Yang Zhou, Nestor Ishimwe, Xiaowan Huang, Liansheng Wang, Longping Wen*, Weiping Wang*, Yunjiao Zhang*. Photoresponsive PAMAM-Assembled Nanocarrier Loaded with Autophagy Inhibitor for Synergistic Cancer Therapy. Small 10, e2102295 (2021) (IF:15.153)
12.Jin P, Wang L, Sha R, Liu L, Qian J, Ishimwe N, Zhang W, Qian J, Zhang YJ*, Wen L*. A blood circulation-prolonging peptide anchored biomimetic phage-platelet hybrid nanoparticle system for prolonged blood circulation and optimized anti-bacterial performance. Theranostics 11(5):2278-2296 (2021). (IF: 11.600)
13.Yunjiao Zhang#*, Xiaowan Huang#, Liansheng Wang#, Cong Cao, Hao Zhang, Pengfei Wei, He Ding, Yang Song, Ziying Chen, Jieying Qian, Suqin Zhong, Zefeng Liu, Meimei Wang, Wenbin Zhang, Wenwei Jiang, Jie Zeng, Guangyu Yao*, Longping Wen*. Glutathionylation -dependent proteasomal degradation of wide- spectrum mutant p53 proteins by engineered zeolitic imidazolate framework-8. Biomaterials 271:120720 (2021) (IF: 15.304)
14.Jieying Qian#, Wenbin Zhang#, Pengfei Wei#, Guangyu Yao*, Tianxiang Yi, Hao Zhang, He Ding, Xiaowan Huang, Meimei Wang, Yang Song, Suqin Zhong, Lijiao Yang, Jinhao Gao, Zijian Zhou, Longping Wen* and Yunjiao Zhang*. Enhancing Chemotherapy of p53-Mutated Cancer through Ubiquitination-Dependent Proteasomal Degradation of Mutant p53 Proteins by Engineered ZnFe-4 Nanoparticles. Advanced Functional Materials 30,2001994 (2020). (IF:19.924)
15.Nestor Ishimwe#, Wenbin Zhang, Jieying Qian, Yunjiao Zhang* and Longping Wen*. Autophagy regulation as a promising approach for improving cancer immunotherapy. Cancer Letters 475,34-42 (2020) (IF: 9.756)
16.Jiqian Zhang, Shasha Zhu, Peipei Jin, Yuting Huang, Qingqing Dai, Qianyun Zhu, Pengfei Wei, Zhilai Yang, Lei Zhang, Hu Liu, Guanghong Xu, Lijian Chen, Erwei Gu, Yunjiao Zhang*, Longping Wen*, Xuesheng Liu*. Graphene oxide improves postoperative cognitive dysfunction by maximally alleviating amyloid beta burden in mice. Theranostics 10(26):11908-11920 (2020). (IF: 11.600)
17.Yunjiao Zhang*, Li Zhang, Jinhao Gao* and Longping Wen*. Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy. Accounts of Chemical Research 52, 3164−3176 (2019) (IF: 24.466)
18.Peipei Jin#, Rui Sha#, Yunjiao Zhang#, Liu Liu, Yunpeng Bian, Jing Qian, Jieying Qian, Jun Lin, Nestor Ishimwe, Yi Hu, Wenbin Zhang, Yanchun Liu, Shiheng Yin, Li Ren* and Longping Wen*. Blood Circulation-Prolonging Peptides for Engineered Nanoparticles Identified via Phage Display. Nano Letters 19, 1467−1478(2019) (IF: 12.262)
19.Zhang YJ, Sha R, Zhang L, Zhang W, Jin P, Xu W, Ding J, Lin J, Qian J, Yao G, Zhang R, Luo F, Zeng J*, Cao J*, Wen LP*.Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer.Nature Commun. 2018;9(1):4236.(2018 IF:12.353)
20.Jin P#, Sha R#, Zhang YJ (co-first author)#, Liu L, Bian YP, J Qian J, Qian JY, Lin J, Ishimwe N, Hu Y, Zhang W, Liu YC, Yin SH, Ren L*, and Wen LP*.Blood Circulation-Prolonging Peptides for Engineered Nanoparticles Identified via Phage Display. Nano Letters. 2019;19(3):1467-1478.(2018 IF:12.080)
21.Yao H, Zhang YJ(Correspondence author) *, Liu L, Xu YC, Liu Xi, Lin J, Zhou W, Wei PF, Jin PP, Wen LP*. Inhibition of lanthanide nanocrystal-induced inflammasome activation in macrophages by a surface coating peptide through abrogation of ROS production and TRPM2-mediated Ca2+ influx. Biomaterials 2016; 108:143-156. (2018 IF:8.806)
22.Liu L, Sha R, Yang LJ, Zhao XM, Zhu YY, Gao JH*, Zhang YJ(Correspondence author) * and Wen LP*. Impact of morphology on iron oxide nanoparticles-induced inflammasome activation in macrophages. ACS Appl. Mater. Inter. 2018; 10 (48):41197-41206. (2018 IF:8.097)
23.Jin PP, Wei PF, Zhang YJ(Correspondence author) *, Lin J, Sha R, Hu Y, Zhang JQ, Zhou W, Yao H, Ren L*, Wen LP*. Autophagy-mediated Clearance of Ubiquitinated Mutant Huntingtin by Graphene Oxide. Nanoscale2016;8(44):18740-18750. (2018 IF:7.233)
24.Yao H, Zhang YJ*, Liu L, Xu YC, Liu Xi, Lin J, Zhou W, Wei PF, Jin PP, Wen LP*. Inhibition of lanthanide nanocrystal-induced inflammasome activation in macrophages by a surface coating peptide through abrogation of ROS production and TRPM2-mediated Ca2+ influx. Biomaterials 2016;108:143-156.
25.Jin PP, Wei PF, Zhang YJ*, Lin J, Sha R, Hu Y, Zhang JQ, Zhou W, Yao H, Ren L*, Wen LP*. Autophagy-mediated Clearance of Ubiquitinated Mutant Huntingtin by Graphene Oxide. Nanoscale 2016;8(44):18740-18750.
26.Lin J, Shi SS, Zhang JQ, Zhang YJ, Zhang L, Liu Y, Jin PP, Wei PF, Shi RH, Zhou W*, Wen LP*. Giant Cellular Vacuoles Induced by Rare Earth Oxide Nanoparticles are Abnormally Enlarged Endo/Lysosomes and Promote mTOR-Dependent TFEB Nucleus Translocation. Small 2016; 12(41):5759-5768.
27.Zhou ZJ, Hu KW, Ma R, Yan Y, Ni B, Zhang YJ, Wen LP, Zhang Q*, Cheng YY*. Dendritic Platinum-Copper Alloy Nanoparticles as Theranostic Agents for Multimodal Imaging and Combined Chemophotothermal Therapy. Adv. Funct. Mater. 2016; 26(33): 5971–5978.
28.Sun R, Shen S, Zhang YJ, Xu CF, Cao ZT, Wen LP, Wang J*. Nanoparticle-Facilitated Autophagy Inhibition Promotes the Efficacy of Chemotherapeutics against Breast Cancer Stem Cells. Biomaterials 2016; 103:44-45.
29.Li FF, Zhi DB, Luo YF, Zhang JQ, Nan X, Zhang YJ, Zhou W, Qiu BS*, Wen LP*, Liang GL*.Core/shell Fe3 O4 /Gd2O3 nanocubes as T 1 -T 2 dual modal MRI contrast agents. Nanoscale 2016; 8(25):12826-33.
30.Wei PF, Jin PP, Barui AK, Hu Y, Zhang L, Zhang JQ, Shi SS, Zhang HR, Lin J, Zhou W, Zhang YJ, Ruan RQ, Patra CR, Wen LP*. Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment. Biomaterials 2015; 73:160-74.
31.Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, Zhang YJ, Zheng F, Zhang J, Xu J, Hu Y, Wang Y, Li Y, Gu N*, Wen LP*.Inhibition of autophagy enhances the anticancer activity of silver nanoparticles. Autophagy 2014;10(11):2006-20.
32.Miao Y, Xu J, Shen Y, Chen L, Bian Y, Hu Y, Zhou W, Zheng F, Man N, Shen Y, Zhang YJ, Wang M*, Wen LP*. Nanoparticle as signaling protein mimic: robust structural and functional modulation of CaMKII upon specific binding to fullerene C60 nanocrystals. ACS Nano 2014;8(6):6131-44.
33.Zhang YJ, Zheng F, Yang T, Zhou W, Liu Y, Man N, Zhang L, Jin N, Dou Q, Zhang Y, Li Z, Wen LP*. Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nat Mater. 2012; 11(9):817-26.