Name: Du Xiao-Jiao

Introduction:

Du Xiao-Jiao, female, Ph. D, Associate professor. Mainly engaged in biomaterials and nanomedicine research. In view of the key bottleneck encountered in drug delivery in vivo for cancer therapy, nano drug delivery systems that can comprehensively overcome the multiple drug delivery barriers are designed, and the nanoproperties (like surface PEG density, PEG length, size, charge, and so on) were optimized to enhance the drug delivery efficiency and antitumor effect. 

Education:

2009-2014, Doctor of Biomaterials, School of Life Sciences, University of Science and Technology of China

2005-2009, Bachelor of Biotechnology, Department of Bio-engineering, Zhengzhou University

Working Experiences:

2016-Present, Associate Professor, Institutes for Life Sciences, School of Medicine, South China University of Technology

2014-2016, Postdoctoral fellow, School of Life Sciences, University of Science and Technology of China

Research Fields:

1. Nanoproperties optimization and diseases treatment: The ability of nanocarriers to overcome in vivo drug delivery barriers is closely related to their nanoproperties. Based on the correlation of nanoproperties with polymer composition, the molecular weight and proportion of hydrophilic and hydrophobic blocks, the initial dispersion of solvents and preparation methods and other factors for self-assembled nanoparticles, we prepared a library of nanoparticles with different nanoproperties like particle size, surface PEG density, PEG length, charge and so on. After obtain a group of nanoparticles with one property change but others same, we systemically study the effect of nanoproperties on nanoparticles biological behaviors. 

2. Nanoparticles for tumor microenvironments regulation and tumor treatment

Tumor microenvironment is closely related to the development and progression of tumors. The specific niches within it may provide a sanctuary for subpopulations tumor cells that affords a survival advantage following drug exposure and may promote acquired drug resistance and metastasis. Extracellular matrix, stromal cells, immune cells are important components of tumor microenvironment, which plays an important role in tumorigenesis. By designing tumor microenvironment regulated drug delivery system to study the ability of tumor microenvironment regulation and tumor treatment. 

Achievements:

Published 26 research papers in related journals such as PNAS, Adv. Mater., Biomaterials;

Implemented a project from National Natural Science Foundation, Guangzhou Science Research Program, Received the General and Special Financial Grant from the China Postdoctoral Science Foundation. As a key member, she has participated in research projects funded by the National Key R&D Program of China and the National Key Basic Research Program.

Phone: 

020-39380989

E-mail:

duxjz@scut.edu.cn