Name: Jin-Zhi Du
Introduction:
The Laboratory of Smart Nanomedicine was established by Dr. Jin-Zhi Du since October 2016. Our lab is highly multidisciplinary,-+ The research interests of our lab involve the development of multifunctional nanoparticles as tools for tumor detection and therapy. Special attention has been paid in the design of smart nanomedicine that enables responsiveness to tumor microenvironment to address the delivery barriers of the drug delivery systems. Up to now, we have published more than 30 papers in prestigious journals including PNAS, J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Nano, Nano Lett., Biomaterials etc. These papers have received nearly 3000 citations from the scientists all over the world. Seven papers are highly cited papers according to Essential Science Indicators. Our research has been funded by National Natural Science Foundation of China (NSFC), Guangdong Provincial Distinguished Young Scholar, and National key R & D program.
Title: Professor
Education:
2006/09-2011/12 Ph. D. in Polymer Chemistry and Biomaterials
Department of Polymer Science & Engineering, and School of Life Sciences, University of Science and Technology of China
2002/09-2006/07 B.S. in Polymer Chemistry and Physics, Department of Polymer Science & Engineering, University of Science and Technology of China
Working Experiences:
2016/10-present Principal Investigator, Professor
Institutes for Life Sciences, School of Medicine, South China University of Technnology
2012/05-2016/08 Postdoctoral Research Fellow
Department of Biomedical Engineering, School of Medicine, Emory University
Supervisor: Prof. Shuming Nie
Research Fields: Nanomedicine, drug delivery, molecular imaging
Phone: (+86) 13929598156
(+86) 20 39380967
E-mail: djzhi@scut.edu.cn
Achievements:
1.Song Shen#, Hong-Jun Li#, Kai-Ge Chen, Yu-Cai Wang, Xian-Zhu Yang, Zhe-Xiong Lian, Jin-Zhi Du*, Jun Wang*, Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy Nano Lett. 2017, 17, 3822–3829 (Top 20 most read articles in June 2017)
2.Hong-Jun Li#, Jin-Zhi Du*,#, Jing Liu, Xiao-Jiao Du, Song Shen, Yan-Hua Zhu, Xiaoyan Wang, Xiaodong Ye, Shuming Nie*, Jun Wang*, Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration ACS Nano 2016, 10, 6753–6761 (ESI highly cited paper, Top 20 most read articles in June 2016)
3.Jin-Zhi Du, Xiao-Jiao Du, Cheng-Qiong Mao, Jun Wang*, Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anti-Cancer Drug Delivery J. Am. Chem. Soc.2011, 133, 17560–17563 (ESI highly cited paper)
4.Jin-Zhi Du, Tian-Meng Sun, Wen-Jing Song, Juan Wu, Jun Wang*, A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery Angew. Chem. Int. Ed. 2010, 49, 3621–3626 (ESI highly cited paper)
5.Hong-Jun Li#, Jin-Zhi Du#, Xiao-Jiao Du#, Cong-Fei Xu, Chun-Yang Sun, Hong-Xia Wang, Zhi-Ting Cao, Xian-Zhu Yang, Yan-Hua Zhu, Shuming Nie*, Jun Wang*, Stimuli-Responsive Clustered Nanoparticles for Improved Tumor Penetration and Therapeutic Efficacy Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 4164–4169 (ESI highly cited paper)
6.Jinzhi Du, Lucas A. Lane, Shuming Nie*, Stimuli-Responsive Nanoparticles for Targeting the Tumor Microenvironment J. Controlled Release 2015, 219, 205–214
7.Chun-Yang Sun#, Yang Liu#, Jin-Zhi Du#, Zhi-Ting Cao, Cong-Fei Xu, Jun Wang*, Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery Angew. Chem. Int. Ed., 2016, 55, 1010–1014 (ESI highly cited paper)
8.Jin-Zhi Du, Cheng-Qiong Mao, You-Yong Yuan, Xian-Zhu Yang, Jun Wang*, Tumor Extracellular Acidity-activated Nanoparticles as Drug Delivery Systems for Enhanced Cancer Therapy Biotech. Adv. 2014, 32, 789–803
9.Jin-Zhi Du, Hong-Yan Long, You-Yong Yuan, Meng-Meng Song, Liang Chen, Hong Bi, Jun Wang*, Micelle-to-Vesicle Morphological Transition via Light-Induced Rapid Hydrophilic Arm Detachment from A Star Polymer Chem. Comm. 2012, 48, 1257-1259
10.Tian-Meng Sun#, Jin-Zhi Du#, Yan-Dan Yao#, Cheng-Qiong Mao, Shuang Dou, Song-Yin Huang, Pei-Zhuo Zhang, Kam W. Leong, Er-Wei Song*, Jun Wang*, Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression ACS Nano 2011, 5, 1483–1494 (ESI highly cited paper)
