Topic: From Molecule to Mammal: Inventing Luminescent Nanoparticles for Biology
Speaker: Prof.Gang Han ,Massachusetts Institute of Technology
Time: 16:00,December 6, 2018
Venue: Room 502, Building of State Key Laboratory of Luminescent Materials and Devices, Wushan Campus.
Abstract: Functional luminescent nanoparticles are promising materials for in vitro and in vivo optical imaging and therapy due to their unique optical and chemical properties. In this talk, I will present a series of biocompatible luminescence nanoparticles. The first type of materials is upconversion nanoparticles (UCNPs). I will present new developments regarding engineering UCNPs towards optogenetic applications1 in neuro-engineering and cancer immunotherapy2. The second type of nanoparticles is persistent luminescence nanoparticles (PLNPs).3 They are bioluminescence-like and possess unprecedented in vivo deep tissue energy rechargeability, outstanding signal-to-noise-ratio with no need for an excitation resource (light) during imaging, and they can be directly detected with existing imaging systems. These nanoparticles continue to emit light for minutes or hours and, in some cases, days, after turning off the excitation source. These long-lasting, light-emitting nanocrystals can provide noninvasive imaging technology for evaluating structural and functional biological processes in living animals and patients. The third is a type of organic Biodpy nanoparticles that were tailored with outstanding NIR absorbing ability. Rather than the conventional laser light needed in PDT, I will present their ultralow power lamp operable PDT applications in deep tissue tumor treatment.4 Finally, I would like also to introduce a new organic upconversion system for in vivo anticancer release. 5
References
1. Wu, X.; Zhang, Y.; Takle, K.; Bilsel, O.; Li, Z.; Lee, H.; Zhang, Z.; Li, D.; Fan, W.; Duan, C.; Chan, E. M.; Lois, C.; Xiang, Y.; Han, G., Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano 2016, 10 (1), 1060-6.
2. He, L.; Zhang, Y.; Ma, G.; Tan, P.; Li, Z.; Zang, S.; Wu, X.; Jing, J.; Fang, S.; Zhou, L., Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. Elife 2015, 4, e10024.
3. (a) Li, Z.; Zhang, Y.; Wu, X.; Maudgal, R.; Zhang, H.; Han, G., In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO2/ZnGa2O4:Cr(3+) Persistent Luminescence Nanocomposites. Adv Sci (Weinh) 2015, 2 (3); (b) Li, Z.; Zhang, Y.; Wu, X.; Huang, L.; Li, D.; Fan, W.; Han, G., Direct Aqueous-Phase Synthesis of Sub-10 nm Luminous Pearls with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence. J Am Chem Soc 2015, 137 (16), 5304-7.
4. (a) Huang, L.; Li, Z.; Zhao, Y.; Zhang, Y.; Wu, S.; Zhao, J.; Han, G., Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy. J Am Chem Soc 2016, 138 (44), 14586-14591; (b) Huang, L.; Li, Z.; Zhao, Y.; Yang, J.; Yang, Y.; Pendharkar, A. I.; Zhang, Y.; Kelmar, S.; Chen, L.; Wu, W.; Zhao, J.; Han, G., Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles. Adv Mater 2017, 29 (28).
5. Huang, L.; Zhao, Y.; Zhang, H.; Huang, K.; Yang, J.; Han, G., Expanding Anti-Stokes Shifting in Triplet-Triplet Annihilation Upconversion for In Vivo Anticancer Prodrug Activation. Angew Chem Int Ed Engl 2017, 56 (46), 14400-14404.
