Name: Dongming Lan
Introduction:Associate Professor
School of Food Science and Engineering
Tel: 020-87113842
Fax: 0086-20-87113842
E-mail: dmlan@scut.edu.cn
Education Background
1999.9~2003.6 Bachelor Degree （Biotechnology）, college of life science, Lanzhou University;
2003.9~2008.12 PhD study on molecular biology and biochemistry, college of life science, Sun YAT-SEN University
Employment Summary
Postdoctoral fellow (2009-2011), School of Bioscience and Bioengineering, South China University of Technology
Postdoctoral fellow (2011-2013), School of Chemistry and Chemical Engineering, South China University of Technology
Lecturer (2013-2017), College of Food science and Engineering, South China University of Technology
Associate Professor (2017-present), College of Food science and Engineering, South China University of Technology
Field of Research
Discovery of new biocatalysts for food application, elucidation of enzymatic mechanism, improving catalytic performance of enzyme by protein engineering
Current Research Projects
1. Effect of lid domain on the catalytic performance of thermostable lipase. The National Natural Science Fund, 21406076，2014-2017
Publications（* as corresponding author）
1.Lan, D., Qu, M., Yang, B., & Wang, Y. (2016). Enhancing production of lipase MAS1 from marine Streptomyces sp. strain in Pichia pastoris by chaperones co-expression. Electronic Journal of Biotechnology, 22, 62–67.
2.Lan, D., Popowicz, G. M., Pavlidis, I. V., Zhou, P., Bornscheuer, U. T., & Wang, Y. (2015). Conversion of a Mono- and Diacylglycerol Lipase into a Triacylglycerol Lipase by Protein Engineering. ChemBioChem, 16(10), 1431–1434.
3.Lan, D., Wang, Q., Popowicz, G. M., Yang, B., Tang, Q., & Wang, Y. (2015). The role of residues 103, 104, and 278 in the activity of SMG1 lipase from Malassezia globosa: A site-directed mutagenesis study. Journal of Microbiology and Biotechnology, 25(11), 1827–1834.
4.Lan, D., Wang, Q., Xu, J., Zhou, P., Yang, B., & Wang, Y. (2015). Residue Asn277 affects the stability and substrate specificity of the SMG1 lipase from Malassezia globosa. International Journal of Molecular Sciences, 16(4), 7273–7288
5.Yuan, D., Lan, D., Xin, R., Yang, B., & Wang, Y. (2016). Screening and characterization of a thermostable lipase from marine Streptomyces sp. strain W007. Biotechnology and Applied Biochemistry, 63(1), 41–50.
6.Guo, S., Xu, J., Pavlidis, I. V., Lan, D., Bornscheuer, U. T., Liu, J., & Wang, Y. (2015). Structure of product-bound SMG1 lipase: Active site gating implications. FEBS Journal, 282(23), 4538–4547.
7.Wang, X., Xu, H., Lan, D., Yang, B., & Wang, Y. (2015). Hydrolysis of lysophosphatidylcholines by a lipase from Malassezia globosa. European Journal of Lipid Science and Technology, 117(10), 1655–1658
8.Xu, H., Lan, D. M., Yang, B., & Wang, Y. H. (2015). Biochemical properties and structure analysis of a DAG-like lipase from Malassezia globosa. International Journal of Molecular Sciences, 16(3), 4865–4879
9.Gao, C., Lan, D., Liu, L., Zhang, H., Yang, B., & Wang, Y. (2014). Site-directed mutagenesis studies of the aromatic residues at the active site of a lipase from Malassezia globosa. Biochimie, 102(1), 29–36
10.Qin, X. L., Huang, H. H., Lan, D. M., Wang, Y. H., & Yang, B. (2014). Typoselectivity of crude geobacillus sp. T1 lipase fused with a cellulose-binding domain and its use in the synthesis of structured lipids. Journal of the American Oil Chemists’ Society, 91(1), 55–62.
11.Qin, X. L., Lan, D. M., Zhong, J. F., Liu, L., Wang, Y. H., & Yang, B. (2014). Fatty acid specificity of T1 lipase and its potential in acylglycerol synthesis. Journal of the Science of Food and Agriculture, 94(8), 1614–1621.
12.Qin, X.-L., Zhong, J.-F., Wang, Y. H., Yang, B., Lan, D.-M., & Wang, F.-H. (2014). 1,3-Dioleoyl-2-palmitoylglycerol-rich human milk fat substitutes: Production, purification, characterization and modeling of the formulation. European Journal of Lipid Science and Technology, 116(3), 282–290.
13.Wang, W., Xu, Y., Qin, X., Lan, D., Yang, B., & Wang, Y. (2014). Immobilization of lipase SMG1 and its application in synthesis of partial glycerides. European Journal of Lipid Science and Technology, 116(8), 1063–1069.
14.Yuan, D., Lan, D., Xin, R., Yang, B., & Wang, Y. (2014). Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649. International Journal of Molecular Sciences, 15(6), 10554–10566.
15.Liu, L., Lan, D., Wang, Q., Gao, C., Li, Z., Yang, B., & Wang, Y. (2013). A “bridge-like” structure responsible for the substrate selectivity of mono- and diacylglycerol lipase from Aspergillus oryzae. Journal of Molecular Catalysis B: Enzymatic, 97, 144–149.
Courses Offered
1. “Food analysis” for undergraduate students
2. “Food Flavor and Chemistry” for graduate student
