(Lecture, April. 18)New probes and techniques for clinical-oriented molecular imaging
Title: Research Progress on Safety Prevention and Control Technology for Thermal Runaway of Energy Storage Batteries
Speaker: Prof. Zhang Xiaobing (Dean, College of Chemistry and Chemical Engineering, Hunan University)
Time: April 18, 2024 15:00
Venue: Conference Room 105, Shaw Engineering Hall
[Abstract]
Optical imaging technology based on molecular probes has become a powerful research tool in the fields of medical detection, clinical surgical navigation and drug development due to the advantages of fast response speed, low damage to samples and real-time dynamic monitoring. However, traditional optical probes are difficult to realize accurate imaging of targets in clinical pathological environments due to problems such as easy signal diffusion, limited response specificity, and large background interference signals in samples. To address these key scientific issues, this group has carried out a series of research work: 1) in order to realize the in situ precise measurement of target molecules in cells and in vivo, this group has developed a series of novel in situ imaging molecular probes based on the mechanism of hydrogen bonding-driven ordered assembly of small molecular probes, and established a new method for fluorescence in situ imaging analysis of small molecular probes; 2) in order to reduce the interference of background signals from clinical samples and enhance the depth of tissue imaging with traditional optical probes, this group has developed a series of new in situ imaging molecular probes. In order to reduce the background signal interference in clinical samples and enhance the tissue imaging depth of traditional optical probes, this group developed a new type of high-brightness long afterglow luminescent material based on electron-rich anthracene derivatives, and developed an organic long afterglow luminescence resonance energy transfer precision imaging analysis method, which realized the long afterglow imaging of awake and free-roaming animals for the first time; (3) in order to achieve the acquisition of biochemical information of complex pathological samples with high specificity, this group developed a series of new in situ imaging molecular probes based on the fluorescence imaging probes. Based on the systematic study of the "structure-effect" relationship of fluorescent imaging probes, the group proposes the strategy of developing highly selective fluorescent probes by molecular structure modulation, and develops a new method of highly selective bio-imaging analysis, which successfully realizes the precise typing of clinical disease samples.
[Biography]
Zhang Xiaobing is a professor of Hunan University, Deputy Director of the Academic Committee of Hunan University, Dean of the School of Chemistry and Chemical Engineering and Deputy Director of the State Key Laboratory. Zhang Xiaobing is a member of the National Outstanding Young Scientist Fund, the National "Ten Thousand People's Program" for Leading Talents in Science and Technology Innovation, and a Fellow of the Chinese Chemical Society. He was awarded the Second Prize of National Natural Science in 2020, the First Prize of Natural Science of Ministry of Education in 2018 and the First Prize of Natural Science of Hunan Province as the first complete author, and was selected as one of the highly cited scholars in China by Elsevier from 2017 to 2023. He has published more than 200 papers, including more than 30 papers in Nat Biomed Eng, Nat photon, PNAS, JACS, Angew Chem and so on.
Announced by School of Chemistry and Chemical Engineering
