Title: Mechanism Analysis and Application Expansion of Acoustic Power Therapy

Speaker: Prof. Huiyu Liu

Time: 15:00-16:00, November 30, 2023

Venue: Conference Room 214,Building 16

[Abstract]

Traditional tumor treatments mainly include surgery, radiotherapy, chemotherapy, etc., but there are problems such as high damage, obvious side effects, easy recurrence, and high cost, therefore, there is an urgent need to develop new strategies for tumor treatment in order to promote the development of clinical oncology treatment technology. In view of this, we propose a new technique of sonodynamic therapy (SDT) utilizing a nano-diagnostic platform to assist interventional therapy. As an emerging non-invasive cancer treatment modality, sonodynamic therapy can effectively penetrate biological tissues to achieve non-invasive treatment of deep lesions. However, at this stage, the development of sonodynamic therapy faces the problems of low material performance, few types, and unknown mechanisms, which limit its further clinicalization. In this regard, we propose to utilize various material modulation methods, such as surface interface engineering, defect engineering, and band gap engineering, to prepare a variety of acoustic kinetic nano-diagnostic platforms with excellent properties, and further reveal the acoustic kinetic mechanism of ultrasonic cavitation and acoustic luminescence, and improve new theories of ultrasonic catalysis and piezoelectric acoustic dynamics, to provide theoretical foundations for the expansion of the application of acoustic kinetic therapies. In addition, we have expanded the application of acoustic kinetic therapy in the treatment of tumors, thrombosis and drug-resistant bacterial infections, and developed new modes of non-invasive interventional therapy, providing new ideas for the clinical application of acoustic kinetic therapy. This report focuses on the progress of our group in the design of acoustic dynamic materials, mechanism analysis and its application in the treatment of various diseases.

[1] H.Y. Liu, et al. Adv. Sci. 2023, 2301152.

[2] H.Y. Liu, et al., Adv. Funct. Mater. 2022, 32, 2112145.

[3] H.Y. Liu, et al., ACS Nano 2021, 15, 20003-20012.

[4] H.Y. Liu, et al., Exploration 2021, 1-12.

[5] H.Y. Liu, et al., Adv. Mater. 2021, 33, 2007073.

[6] H.Y. Liu, et al., Angew. Chem. Int. Ed. 2020, 59, 13557-13561.

[7] H.Y. Liu, et al., Adv. Mater. 2018, 30, 1800180.

[Biography]

Huiyu Liu, Professor, Doctoral Supervisor, recipient of the Outstanding Youth Fund of the National Natural Science Foundation of China (NSFC), the National Outstanding Youth Fund of China (NOYF), and the Newton Advanced Scholarship Fund (NASF), graduated from the Institute of Physics and Chemistry of the Chinese Academy of Sciences (TIPC) with a Ph.D. degree in July 2007 and stayed in TIPC for the rest of his career. Since November, he has been a professor at Beijing University of Chemical Technology (BUCT). He has published more than 110 papers in international journals such as Angew. Chem. Int. Ed., J. Am. Chem. Soc. and Adv. Mater. with more than 10,000 citations, 13 highly cited papers in ESI, 48 H-index, and 16 authorized invention patents. He serves as associate editor of Exploration journal under Wiley, editorial board member of Materials&Design, editorial board member of Mater. Express, and youth editorial board member of Journal of Inorganic Chemistry. He is a standing member of the Nano Biotechnology Branch of the Chinese Association of Pharmaceutical Biotechnology. He was awarded the Second Prize of Beijing Medical Science and Technology Award (Rank 2), Young Science and Technology Award of China Medical Science and Technology Award, Lu Jiaxi Young Talent Award of Chinese Academy of Sciences, Beijing Science and Technology Rising Star, and Doctoral Supervisor of Jingbo Science and Technology Prize-Jingbo Outstanding Doctoral Dissertation Award of Excellence. He has been selected by Angewandte as one of the top 25 highly cited original researchers in the world in 2019/2020, and has been selected by Elsevier & Stanford as one of the top 100,000 general scientists in the world in the annual "Standardized Citation Index for General Practice Authors Database" from 2019-2022 onwards. Impact list of 100,000 general practitioner scientists around the world published by Elsevier & Stanford.

Announced by School of Chemistry and Chemical Engineering